Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 TNFRSF13C 1件: Primary immunodeficiency D12151 Ianalumab 7件: 35, 46, 49, 53, 61, 63, 95
2 IL2RG 4件: Viral protein interaction with cytokine and cytokine receptor, Th1 and Th2 cell differentiation, Th17 cell differentiation, Primary immunodeficiency D00748 Aldesleukin 6件: 2, 35, 49, 65, 96, 97
3 JAK3 5件: Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Viral carcinogenesis, Primary immunodeficiency D09970 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300
4 JAK3 5件: Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Viral carcinogenesis, Primary immunodeficiency D10653 Peficitinib 1件: 46
5 LCK 5件: Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Yersinia infection, Primary immunodeficiency D03658 Dasatinib 2件: 51, 85
6 LCK 5件: Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Yersinia infection, Primary immunodeficiency D06414 Dasatinib 2件: 51, 85
7 BTK 1件: Primary immunodeficiency D10223 Ibrutinib 3件: 28, 60, 61
8 BTK 1件: Primary immunodeficiency D10893 Acalabrutinib 2件: 46, 61
9 BTK 1件: Primary immunodeficiency D11422 Zanubrutinib 5件: 13, 63, 222, 300, 331
10 BTK 1件: Primary immunodeficiency D11457 Fenebrutinib 1件: 13
11 BTK 1件: Primary immunodeficiency D11478 Branebrutinib 3件: 46, 49, 53
12 BTK 1件: Primary immunodeficiency D12160 Orelabrutinib 4件: 13, 49, 61, 63
13 BTK 1件: Primary immunodeficiency D12285 Remibrutinib 2件: 13, 53
14 BTK 1件: Primary immunodeficiency D12467 Evobrutinib 3件: 13, 46, 49
15 CD3D 4件: Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Primary immunodeficiency D06314 Visilizumab 2件: 96, 97
16 CD3D 4件: Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Primary immunodeficiency D08959 Otelixizumab 1件: 46
17 CD3E 4件: Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Primary immunodeficiency D06314 Visilizumab 2件: 96, 97
18 CD3E 4件: Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Primary immunodeficiency D08959 Otelixizumab 1件: 46
19 CD3E 4件: Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Primary immunodeficiency D11463 Mosunetuzumab 1件: 49
20 CD4 7件: Viral life cycle - HIV-1, Virion - Human immunodeficiency virus, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Yersinia infection, Primary immunodeficiency D06356 Zanolimumab 1件: 46
21 CD19 1件: Primary immunodeficiency D11496 Obexelimab 1件: 300
22 CD19 1件: Primary immunodeficiency D11757 Inebilizumab 4件: 11, 13, 51, 300
23 CD40 6件: Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Systemic lupus erythematosus, Primary immunodeficiency, Viral myocarditis D11357 Bleselumab 1件: 222
24 CD40 6件: Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Systemic lupus erythematosus, Primary immunodeficiency, Viral myocarditis D11597 Ravagalimab 2件: 53, 97
25 CD40 6件: Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Systemic lupus erythematosus, Primary immunodeficiency, Viral myocarditis D11610 Iscalimab 2件: 49, 53
26 CD40LG 5件: T cell receptor signaling pathway, Toxoplasmosis, Systemic lupus erythematosus, Primary immunodeficiency, Viral myocarditis D06193 Toralizumab 1件: 63