Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	MAPK14	[62] Endocrine resistance, MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, S ...	D09639	Losmapimod	[2] 113, 222
2	MAPK14	[62] Endocrine resistance, MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, S ...	D10959	Neflamapimod	[1] 8
3	ADRA1D	[6] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, ...	D00076	Norepinephrine	[2] 22, 296
4	ADRA1D	[6] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, ...	D00095	Epinephrine	[3] 46, 70, 96
5	ADRA1D	[6] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, ...	D00124	Ephedrine	[1] 11
6	ADRA1D	[6] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, ...	D00255	Carvedilol	[4] 57, 86, 113, 210
7	ADRA1D	[6] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, ...	D00454	Olanzapine	[2] 2, 8
8	ADRA1D	[6] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, ...	D01277	Droxidopa	[5] 5, 6, 17, 169, 170
9	ADRA1D	[6] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, ...	D02349	Dipivefrin	[1] 6
10	ADRA1D	[6] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, ...	D02910	Amiodarone	[2] 28, 127

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