Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	MAPK14	[50] MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling ...	D09639	Losmapimod	[2] 113, 222
2	MAPK14	[50] MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling ...	D10959	Neflamapimod	[1] 8
3	EGFR	[33] MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, ...	D01977	Gefitinib	[1] 75
4	EGFR	[33] MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, ...	D03455	Cetuximab	[2] 51, 86
5	EGFR	[33] MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, ...	D07907	Erlotinib	[1] 94
6	EGFR	[33] MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, ...	D08108	Lapatinib	[3] 34, 74, 75
7	EGFR	[33] MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, ...	D08950	Neratinib	[1] 34
8	EGFR	[33] MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, ...	D11251	Icotinib	[1] 34
9	EGFR	[33] MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, ...	D11772	Tesevatinib	[1] 67
10	CXCR1	[3] Viral protein interaction with cytokine and cytokine receptor, Phospholipase D signaling pathway ...	D08984	Reparixin	[2] 298, 299

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