Target Gene/Pathway Pathway / Gene

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KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[2] Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases

Fenfluramine 💬

[4] 140, 144, 145, 149 💬

2

[1] Primary bile acid biosynthesis

Soticlestat 💬

[2] 140, 144 💬

3

[4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Thermogenesis, Retrograde endoc ...

Cannabidiol 💬

[20] 2, 6, 8, 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
6	Parkinson disease
8	Huntington disease
13	Multiple sclerosis/Neuromyelitis optica
36	Epidermolysis bullosa
46	Malignant rheumatoid arthritis
51	Scleroderma
95	Autoimmune hepatitis
96	Crohn disease
97	Ulcerative colitis
140	Dorabe syndrome
144	Lennox-Gastaut syndrome
145	West syndrome
156	Rett syndrome
157	Sturge-Weber syndrome
158	Tuberous sclerosis
193	Prader-Willi syndrome
206	Fragile X syndrome
226	Interstitial cystitis with Hunners ulcer
271	Ankylosing spondylitis

4

[1] Neuroactive ligand-receptor interaction

Cannabidiol 💬

[20] 2, 6, 8, 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
6	Parkinson disease
8	Huntington disease
13	Multiple sclerosis/Neuromyelitis optica
36	Epidermolysis bullosa
46	Malignant rheumatoid arthritis
51	Scleroderma
95	Autoimmune hepatitis
96	Crohn disease
97	Ulcerative colitis
140	Dorabe syndrome
144	Lennox-Gastaut syndrome
145	West syndrome
156	Rett syndrome
157	Sturge-Weber syndrome
158	Tuberous sclerosis
193	Prader-Willi syndrome
206	Fragile X syndrome
226	Interstitial cystitis with Hunners ulcer
271	Ankylosing spondylitis

5

[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse ...

Topiramate 💬

[6] 6, 97, 140, 144, 156, 193 💬

6

[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse ...

[2] 140, 144 💬

7

[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse ...

Topiramate 💬

[6] 6, 97, 140, 144, 156, 193 💬

8

[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse ...

[2] 140, 144 💬

9

[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse ...

Topiramate 💬

[6] 6, 97, 140, 144, 156, 193 💬

10

[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse ...

[2] 140, 144 💬

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