Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	IFNG	29件: Proteasome, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Necroptosis, TGF-b ...	D04242	Fontolizumab	1件: 46
2	IFNG	29件: Proteasome, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Necroptosis, TGF-b ...	D11120	Emapalumab	3件: 49, 65, 107
3	TNF	58件: MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with ...	D00742	Etanercept	16件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285
4	TNF	58件: MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with ...	D00754	Thalidomide	20件: 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331
5	TNF	58件: MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with ...	D01583	Pirfenidone	11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
6	TNF	58件: MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with ...	D02597	Adalimumab	17件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271
7	TNF	58件: MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with ...	D02598	Infliximab	27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 1 ...
8	TNF	58件: MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with ...	D03441	Certolizumab pegol	8件: 37, 46, 49, 96, 97, 107, 226, 271
9	TNF	58件: MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with ...	D04358	Golimumab	8件: 46, 56, 84, 96, 97, 107, 270, 271
10	TNF	58件: MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with ...	D04687	Lenalidomide	8件: 16, 26, 28, 34, 49, 284, 300, 331

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