Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 CFTR 6件: cAMP signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection D09916 Ivacaftor 1件: 299
2 CFTR 6件: cAMP signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection D10134 Lumacaftor 1件: 299
3 CFTR 6件: cAMP signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection D11041 Tezacaftor 1件: 299
4 CFTR 6件: cAMP signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection D11423 Deutivacaftor 1件: 299
5 CFTR 6件: cAMP signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection D11507 Elexacaftor 1件: 299
6 CFTR 6件: cAMP signaling pathway, Tight junction, Gastric acid secretion, Pancreatic secretion, Bile secretion, Vibrio cholerae infection D11724 Galicaftor 1件: 299
7 HMGCR 3件: Terpenoid backbone biosynthesis, Metabolic pathways, Bile secretion D00359 Lovastatin 11件: 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310
8 HMGCR 3件: Terpenoid backbone biosynthesis, Metabolic pathways, Bile secretion D00434 Simvastatin 21件: 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
9 HMGCR 3件: Terpenoid backbone biosynthesis, Metabolic pathways, Bile secretion D07474 Atorvastatin 19件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299
10 HMGCR 3件: Terpenoid backbone biosynthesis, Metabolic pathways, Bile secretion D07983 Fluvastatin 3件: 79, 218, 222
11 HMGCR 3件: Terpenoid backbone biosynthesis, Metabolic pathways, Bile secretion D08410 Pravastatin 9件: 13, 46, 49, 67, 79, 96, 164, 265, 333
12 HMGCR 3件: Terpenoid backbone biosynthesis, Metabolic pathways, Bile secretion D08492 Rosuvastatin 11件: 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299
13 ATP1A1 15件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption D00297 Digitoxin 1件: 299
14 ATP1A1 15件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption D00298 Digoxin 3件: 8, 46, 210
15 ATP1A2 15件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption D00297 Digitoxin 1件: 299
16 ATP1A2 15件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption D00298 Digoxin 3件: 8, 46, 210
17 ATP1A3 15件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption D00297 Digitoxin 1件: 299
18 ATP1A3 15件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption D00298 Digoxin 3件: 8, 46, 210
19 ATP1A4 15件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption D00297 Digitoxin 1件: 299
20 ATP1A4 15件: cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Insulin secretion, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Carbohydrate digestion and absorption, Protein digestion and absorption, Bile secretion, Mineral absorption D00298 Digoxin 3件: 8, 46, 210
21 RXRA 16件: PPAR signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Non-alcoholic fatty liver disease, Bile secretion, Hepatitis C, Pathways in cancer, Transcriptional misregulation in cancer, Chemical carcinogenesis - receptor activation, Thyroid cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer, Lipid and atherosclerosis D02754 Acitretin 1件: 37
22 RXRA 16件: PPAR signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Non-alcoholic fatty liver disease, Bile secretion, Hepatitis C, Pathways in cancer, Transcriptional misregulation in cancer, Chemical carcinogenesis - receptor activation, Thyroid cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer, Lipid and atherosclerosis D02815 Alitretinoin 1件: 49
23 RXRA 16件: PPAR signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Non-alcoholic fatty liver disease, Bile secretion, Hepatitis C, Pathways in cancer, Transcriptional misregulation in cancer, Chemical carcinogenesis - receptor activation, Thyroid cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer, Lipid and atherosclerosis D03106 Bexarotene 2件: 13, 75
24 SLC10A1 2件: Bile secretion, Hepatitis B D10951 Maralixibat 3件: 296, 297, 338
25 SLC10A2 1件: Bile secretion D10796 Elobixibat 1件: 6
26 SLC10A2 1件: Bile secretion D10951 Maralixibat 3件: 296, 297, 338
27 SLC10A2 1件: Bile secretion D11716 Odevixibat 3件: 296, 297, 338
28 CA2 7件: Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion D00218 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
29 CA2 7件: Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion D00518 Diclofenamide 1件: 114
30 CA2 7件: Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
31 CA2 7件: Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion D07871 Dorzolamide 1件: 90
32 NR1H4 1件: Bile secretion D00163 Chenodeoxycholic acid 4件: 20, 96, 234, 263
33 NR1H4 1件: Bile secretion D00734 Ursodeoxycholic acid 14件: 6, 8, 20, 46, 67, 84, 93, 94, 95, 96, 97, 234, 296, 299
34 NR1H4 1件: Bile secretion D09360 Obeticholic acid 3件: 93, 265, 296
35 NR1H4 1件: Bile secretion D10699 Cholic Acid 4件: 20, 234, 265, 310
36 NR1H4 1件: Bile secretion D11548 Tropifexor 1件: 93