Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	MET	21件: EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 ...	D10062	Cabozantinib	1件: 34
2	PIK3CA	96件: Inositol phosphate metabolism, Metabolic pathways, EGFR tyrosine kinase inhibitor resistance, E ...	D11011	Alpelisib	1件: 138
3	PIK3CA	96件: Inositol phosphate metabolism, Metabolic pathways, EGFR tyrosine kinase inhibitor resistance, E ...	D11158	Leniolisib	2件: 53, 65
4	PIK3CB	96件: Inositol phosphate metabolism, Metabolic pathways, EGFR tyrosine kinase inhibitor resistance, E ...	D11158	Leniolisib	2件: 53, 65
5	PIK3CD	96件: Inositol phosphate metabolism, Metabolic pathways, EGFR tyrosine kinase inhibitor resistance, E ...	D11158	Leniolisib	2件: 53, 65
6	PIK3CD	96件: Inositol phosphate metabolism, Metabolic pathways, EGFR tyrosine kinase inhibitor resistance, E ...	D11437	Parsaclisib	3件: 35, 53, 61
7	SRC	40件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Rap1 s ...	D03252	Bosutinib	2件: 2, 67
8	SRC	40件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Rap1 s ...	D03658	Dasatinib	2件: 51, 85
9	SRC	40件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Rap1 s ...	D06414	Dasatinib	2件: 51, 85
10	SRC	40件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Rap1 s ...	D09664	Saracatinib	3件: 6, 89, 272

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