Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 MAPK14 9件: VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
2 MAPK14 9件: VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
3 IFNG 5件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis D04242 Fontolizumab 1件: 46
4 IFNG 5件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis D11120 Emapalumab 3件: 49, 65, 107
5 IFNGR1 4件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis D00747 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326
6 IFNGR2 4件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis D00747 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326
7 IL2RA 3件: Viral protein interaction with cytokine and cytokine receptor, Th1 and Th2 cell differentiation, Th17 cell differentiation D00748 Aldesleukin 6件: 2, 35, 49, 65, 96, 97
8 IL2RA 3件: Viral protein interaction with cytokine and cytokine receptor, Th1 and Th2 cell differentiation, Th17 cell differentiation D03058 Basiliximab 6件: 2, 50, 66, 97, 222, 228
9 IL2RA 3件: Viral protein interaction with cytokine and cytokine receptor, Th1 and Th2 cell differentiation, Th17 cell differentiation D03639 Daclizumab 8件: 13, 56, 60, 65, 97, 107, 283, 284
10 IL2RB 4件: Viral protein interaction with cytokine and cytokine receptor, Th1 and Th2 cell differentiation, Th17 cell differentiation, Transcriptional misregulation in cancer D00748 Aldesleukin 6件: 2, 35, 49, 65, 96, 97
11 IL2RG 3件: Viral protein interaction with cytokine and cytokine receptor, Th1 and Th2 cell differentiation, Th17 cell differentiation D00748 Aldesleukin 6件: 2, 35, 49, 65, 96, 97
12 IL4 2件: Th1 and Th2 cell differentiation, Th17 cell differentiation D03117 Binetrakin 1件: 46
13 IL4R 2件: Th1 and Th2 cell differentiation, Th17 cell differentiation D10354 Dupilumab 5件: 51, 97, 98, 160, 162
14 IL5 1件: Th1 and Th2 cell differentiation D04923 Mepolizumab 4件: 44, 45, 98, 162
15 IL5 1件: Th1 and Th2 cell differentiation D08985 Reslizumab 2件: 44, 98
16 IL12A 5件: Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis D09214 Ustekinumab 16件: 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
17 IL12B 5件: Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis D09214 Ustekinumab 16件: 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
18 IL13 1件: Th1 and Th2 cell differentiation D08857 Anrukinzumab 1件: 97
19 IL13 1件: Th1 and Th2 cell differentiation D09633 Lebrikizumab 1件: 85
20 IL13 1件: Th1 and Th2 cell differentiation D09979 Tralokinumab 2件: 85, 97
21 JAK1 5件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D09959 Ruxolitinib 3件: 60, 65, 228
22 JAK1 5件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D09970 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300
23 JAK1 5件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10308 Baricitinib 13件: 2, 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325
24 JAK1 5件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10653 Peficitinib 1件: 46
25 JAK1 5件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10871 Filgotinib 6件: 46, 53, 96, 97, 222, 271
26 JAK1 5件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10944 Itacitinib 4件: 46, 51, 97, 228
27 JAK1 5件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10994 Upadacitinib 8件: 40, 41, 46, 49, 96, 97, 107, 271
28 JAK1 5件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D11400 Abrocitinib 1件: 84
29 JAK2 4件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis D09959 Ruxolitinib 3件: 60, 65, 228
30 JAK2 4件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis D09970 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300
31 JAK2 4件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis D10308 Baricitinib 13件: 2, 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325
32 JAK2 4件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis D10653 Peficitinib 1件: 46
33 JAK3 3件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Viral carcinogenesis D09970 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300
34 JAK3 3件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Viral carcinogenesis D10653 Peficitinib 1件: 46
35 LCK 3件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Yersinia infection D03658 Dasatinib 2件: 51, 85
36 LCK 3件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Yersinia infection D06414 Dasatinib 2件: 51, 85
37 NFKB1 9件: Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis D01146 Iguratimod 5件: 46, 51, 53, 271, 300
38 PPP3CA 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00107 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
39 PPP3CA 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
40 PPP3CA 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D05480 Pimecrolimus 1件: 160
41 PPP3CA 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D08556 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
42 PPP3CA 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D09033 Voclosporin 2件: 49, 222
43 PPP3CB 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00107 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
44 PPP3CB 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
45 PPP3CB 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D05480 Pimecrolimus 1件: 160
46 PPP3CB 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D08556 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
47 PPP3CB 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D09033 Voclosporin 2件: 49, 222
48 PPP3CC 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00107 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
49 PPP3CC 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
50 PPP3CC 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D05480 Pimecrolimus 1件: 160
51 PPP3CC 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D08556 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
52 PPP3CC 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D09033 Voclosporin 2件: 49, 222
53 PPP3R1 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00107 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
54 PPP3R1 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
55 PPP3R1 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D05480 Pimecrolimus 1件: 160
56 PPP3R1 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D08556 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
57 PPP3R1 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D09033 Voclosporin 2件: 49, 222
58 PPP3R2 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00107 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
59 PPP3R2 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
60 PPP3R2 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D05480 Pimecrolimus 1件: 160
61 PPP3R2 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D08556 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
62 PPP3R2 5件: Wnt signaling pathway, VEGF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis D09033 Voclosporin 2件: 49, 222
63 PRKCQ 3件: Vascular smooth muscle contraction, Th1 and Th2 cell differentiation, Th17 cell differentiation D09671 Sotrastaurin 1件: 97
64 MAPK11 9件: VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
65 MAPK11 9件: VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
66 MAPK13 9件: VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
67 MAPK13 9件: VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
68 RELA 9件: Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis D12181 Edasalonexent 1件: 113
69 MAPK12 9件: VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
70 MAPK12 9件: VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
71 TYK2 3件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis D09970 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300
72 TYK2 3件: Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis D11817 Deucravacitinib 3件: 49, 96, 97
73 CD3D 2件: Th1 and Th2 cell differentiation, Th17 cell differentiation D06314 Visilizumab 2件: 96, 97
74 CD3D 2件: Th1 and Th2 cell differentiation, Th17 cell differentiation D08959 Otelixizumab 1件: 46
75 CD3E 2件: Th1 and Th2 cell differentiation, Th17 cell differentiation D06314 Visilizumab 2件: 96, 97
76 CD3E 2件: Th1 and Th2 cell differentiation, Th17 cell differentiation D08959 Otelixizumab 1件: 46
77 CD3E 2件: Th1 and Th2 cell differentiation, Th17 cell differentiation D11463 Mosunetuzumab 1件: 49
78 CD3G 2件: Th1 and Th2 cell differentiation, Th17 cell differentiation D06314 Visilizumab 2件: 96, 97
79 CD3G 2件: Th1 and Th2 cell differentiation, Th17 cell differentiation D08959 Otelixizumab 1件: 46
80 CD4 5件: Viral life cycle - HIV-1, Virion - Human immunodeficiency virus, Th1 and Th2 cell differentiation, Th17 cell differentiation, Yersinia infection D06356 Zanolimumab 1件: 46