Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	CDK4	[3] Tight junction, T cell receptor signaling pathway, Viral carcinogenesis	D10688	Abemaciclib	[1] 34
2	MAPK14	[10] VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, ...	D09639	Losmapimod	[2] 113, 222
3	MAPK14	[10] VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, ...	D10959	Neflamapimod	[1] 8
4	CSF2	[3] T cell receptor signaling pathway, TNF signaling pathway, Transcriptional misregulation in cance ...	D11343	Otilimab	[1] 46
5	CTLA4	[1] T cell receptor signaling pathway	D04603	Ipilimumab	[1] 159
6	CTLA4	[1] T cell receptor signaling pathway	D06657	Tremelimumab	[1] 96
7	FYN	[2] T cell receptor signaling pathway, Viral myocarditis	D03658	Dasatinib	[2] 51, 85
8	FYN	[2] T cell receptor signaling pathway, Viral myocarditis	D06414	Dasatinib	[2] 51, 85
9	IFNG	[7] TGF-beta signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell ...	D04242	Fontolizumab	[1] 46
10	IFNG	[7] TGF-beta signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell ...	D11120	Emapalumab	[3] 49, 65, 107

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