Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	COMT	[4] Steroid hormone biosynthesis, Tyrosine metabolism, Metabolic pathways, Dopaminergic synapse	D00781	Entacapone	[2] 6, 17
2	COMT	[4] Steroid hormone biosynthesis, Tyrosine metabolism, Metabolic pathways, Dopaminergic synapse	D00786	Tolcapone	[3] 6, 28, 127
3	COMT	[4] Steroid hormone biosynthesis, Tyrosine metabolism, Metabolic pathways, Dopaminergic synapse	D10825	Opicapone	[1] 6
4	MAPK14	[52] Endocrine resistance, MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, S ...	D09639	Losmapimod	[2] 113, 222
5	MAPK14	[52] Endocrine resistance, MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, S ...	D10959	Neflamapimod	[1] 8
6	DDC	[6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Seroto ...	D00558	Carbidopa	[7] 6, 13, 17, 90, 140, 164, 201
7	DDC	[6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Seroto ...	D03082	Benserazide	[1] 6
8	DRD1	[5] Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, ...	D00059	Levodopa	[6] 6, 17, 90, 140, 164, 201
9	DRD1	[5] Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, ...	D01044	Flupentixol	[1] 97
10	DRD1	[5] Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, ...	D07460	Apomorphine	[3] 5, 6, 7

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