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No.
KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
Disease ID
1
MAPK14
[37]
MAPK signaling pathway
MAPK signaling pathway
,
Rap1 signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Toxoplasmosis
,
Tuberculosis
,
Proteoglycans in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Lipid and atherosclerosis
[37]
MAPK signaling pathway
,
Rap1 signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
, ...
D09639
D09639
Losmapimod
[2]
113
113
,
222
2
MAPK14
[37]
MAPK signaling pathway
MAPK signaling pathway
,
Rap1 signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Toxoplasmosis
,
Tuberculosis
,
Proteoglycans in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Lipid and atherosclerosis
[37]
MAPK signaling pathway
,
Rap1 signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
, ...
D10959
D10959
Neflamapimod
[1]
8
8
3
IFNG
[17]
Proteasome
Proteasome
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Natural killer cell mediated cytotoxicity
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Type I diabetes mellitus
,
Leishmaniasis
,
Malaria
,
Toxoplasmosis
,
Tuberculosis
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
[17]
Proteasome
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Natural killer
...
D04242
D04242
Fontolizumab
[1]
46
46
4
IFNG
[17]
Proteasome
Proteasome
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Natural killer cell mediated cytotoxicity
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Type I diabetes mellitus
,
Leishmaniasis
,
Malaria
,
Toxoplasmosis
,
Tuberculosis
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
[17]
Proteasome
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Natural killer
...
D11120
D11120
Emapalumab
[3]
49
49
,
65
,
107
5
IFNGR1
[10]
Necroptosis
Necroptosis
,
Osteoclast differentiation
,
Natural killer cell mediated cytotoxicity
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Leishmaniasis
,
Toxoplasmosis
,
Tuberculosis
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
[10]
Necroptosis
,
Osteoclast differentiation
,
Natural killer cell mediated cytotoxicity
,
Th1 and Th2
...
D00747
D00747
Interferon gamma-1b
[7]
18
18
,
65
,
85
,
228
,
299
,
301
,
326
6
IFNGR2
[10]
Necroptosis
Necroptosis
,
Osteoclast differentiation
,
Natural killer cell mediated cytotoxicity
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Leishmaniasis
,
Toxoplasmosis
,
Tuberculosis
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
[10]
Necroptosis
,
Osteoclast differentiation
,
Natural killer cell mediated cytotoxicity
,
Th1 and Th2
...
D00747
D00747
Interferon gamma-1b
[7]
18
18
,
65
,
85
,
228
,
299
,
301
,
326
7
IL1A
[12]
MAPK signaling pathway
MAPK signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
Non-alcoholic fatty liver disease
,
Type I diabetes mellitus
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Pertussis
,
Leishmaniasis
,
Tuberculosis
,
Measles
,
Rheumatoid arthritis
[12]
MAPK signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
Non-alcoholic fatty liver dise
...
D01583
D01583
Pirfenidone
[11]
13
13
,
34
,
46
,
50
,
51
,
58
,
84
,
85
,
164
,
222
,
228
8
IL1A
[12]
MAPK signaling pathway
MAPK signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
Non-alcoholic fatty liver disease
,
Type I diabetes mellitus
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Pertussis
,
Leishmaniasis
,
Tuberculosis
,
Measles
,
Rheumatoid arthritis
[12]
MAPK signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
Non-alcoholic fatty liver dise
...
D06635
D06635
Rilonacept
[4]
51
51
,
106
,
107
,
266
9
IL1A
[12]
MAPK signaling pathway
MAPK signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
Non-alcoholic fatty liver disease
,
Type I diabetes mellitus
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Pertussis
,
Leishmaniasis
,
Tuberculosis
,
Measles
,
Rheumatoid arthritis
[12]
MAPK signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
Non-alcoholic fatty liver dise
...
D11253
D11253
Bermekimab
[1]
51
51
10
IL1B
[23]
MAPK signaling pathway
MAPK signaling pathway
,
NF-kappa B signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
Th17 cell differentiation
,
TNF signaling pathway
,
Non-alcoholic fatty liver disease
,
Type I diabetes mellitus
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Malaria
,
Tuberculosis
,
Measles
,
Rheumatoid arthritis
,
Lipid and atherosclerosis
[23]
MAPK signaling pathway
,
NF-kappa B signaling pathway
,
Necroptosis
,
Osteoclast differentiation
, ...
D01583
D01583
Pirfenidone
[11]
13
13
,
34
,
46
,
50
,
51
,
58
,
84
,
85
,
164
,
222
,
228