Target Gene/Pathway Pathway / Gene

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KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[4] Cell adhesion molecules, T cell receptor signaling pathway, Autoimmune thyroid disease, Rheumato ...

Ipilimumab 💬

[1] 159 💬

2

[4] Cell adhesion molecules, T cell receptor signaling pathway, Autoimmune thyroid disease, Rheumato ...

Tremelimumab 💬

[1] 96 💬

3

[2] Cell adhesion molecules, PD-L1 expression and PD-1 checkpoint pathway in cancer

Atezolizumab 💬

[1] 85 💬

4

[2] Cell adhesion molecules, PD-L1 expression and PD-1 checkpoint pathway in cancer

Durvalumab 💬

[1] 85 💬

5

[14] PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Cell adhesion molecules, ...

Firategrast 💬

[1] 13 💬

6

[14] PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Cell adhesion molecules, ...

Natalizumab 💬

[6] 13, 15, 25, 46, 63, 96 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica
15	Inclusion body myositis
25	Progressive multifocal leukoencephalopathy
46	Malignant rheumatoid arthritis
63	Idiopathic thrombocytopenic purpura
96	Crohn disease

7

[14] PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Cell adhesion molecules, ...

Vedolizumab 💬

[3] 94, 96, 97 💬

8

[14] PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Cell adhesion molecules, ...

[2] 96, 97 💬

9

[12] Rap1 signaling pathway, Cell adhesion molecules, Neutrophil extracellular trap formation, Natur ...

Efalizumab 💬

[9] 11, 13, 37, 46, 49, 53, 61, 95, 96 💬

Disease ID	Name
11	Myasthenia gravis
13	Multiple sclerosis/Neuromyelitis optica
37	Generalised pustular psoriasis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
53	Sjogren syndrome
61	Autoimmune hemolytic anemia
95	Autoimmune hepatitis
96	Crohn disease

10

[11] PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Cell adhesion molecules, ...

Vedolizumab 💬

[3] 94, 96, 97 💬

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