Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	CDK4	27件: Endocrine resistance, Cell cycle, p53 signaling pathway, PI3K-Akt signaling pathway, Cellular s ...	D10688	Abemaciclib	1件: 34
2	EGFR	47件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...	D01977	Gefitinib	1件: 75
3	EGFR	47件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...	D03455	Cetuximab	2件: 51, 86
4	EGFR	47件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...	D07907	Erlotinib	1件: 94
5	EGFR	47件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...	D08108	Lapatinib	3件: 34, 74, 75
6	EGFR	47件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...	D08950	Neratinib	1件: 34
7	EGFR	47件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...	D11251	Icotinib	1件: 34
8	EGFR	47件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...	D11772	Tesevatinib	1件: 67
9	ERBB2	21件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Platinum drug resistance, MAPK ...	D08108	Lapatinib	3件: 34, 74, 75
10	ERBB2	21件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Platinum drug resistance, MAPK ...	D08950	Neratinib	1件: 34

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