Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	CNR1	[3] Rap1 signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling	D00306	Dronabinol	[8] 2, 8, 13, 36, 46, 96, 271, 298
2	CNR1	[3] Rap1 signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling	D05099	Nabilone	[3] 6, 13, 127
3	CNR1	[3] Rap1 signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling	D05731	Rimonabant	[1] 193
4	CNR1	[3] Rap1 signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling	D10915	Cannabidiol	[20] 2, 6, 8, 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
5	ADORA2A	[2] Rap1 signaling pathway, Vascular smooth muscle contraction	D00045	Adenosine	[3] 13, 58, 65
6	ADORA2A	[2] Rap1 signaling pathway, Vascular smooth muscle contraction	D00528	Caffeine	[8] 2, 6, 21, 46, 78, 96, 97, 265
7	ADORA2A	[2] Rap1 signaling pathway, Vascular smooth muscle contraction	D01453	Caffeine	[8] 2, 6, 21, 46, 78, 96, 97, 265
8	ADORA2A	[2] Rap1 signaling pathway, Vascular smooth muscle contraction	D02769	Adenosine phosphate	[1] 46
9	ADORA2A	[2] Rap1 signaling pathway, Vascular smooth muscle contraction	D04641	Istradefylline	[1] 6
10	ADORA2A	[2] Rap1 signaling pathway, Vascular smooth muscle contraction	D05711	Regadenoson	[1] 58

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