Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	MAPK14	[20] Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathw ...	D09639	Losmapimod	[2] 113, 222
2	MAPK14	[20] Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathw ...	D10959	Neflamapimod	[1] 8
3	CYP17A1	[2] Steroid hormone biosynthesis, Prolactin signaling pathway	D00351	Ketoconazole	[3] 8, 13, 75
4	CYP17A1	[2] Steroid hormone biosynthesis, Prolactin signaling pathway	D10950	Levoketoconazole	[1] 75
5	ESR1	[3] Prolactin signaling pathway, Thyroid hormone signaling pathway, Proteoglycans in cancer	D00105	Estradiol	[7] 13, 46, 49, 65, 76, 226, 299
6	ESR1	[3] Prolactin signaling pathway, Thyroid hormone signaling pathway, Proteoglycans in cancer	D00185	Estriol	[2] 13, 227
7	ESR1	[3] Prolactin signaling pathway, Thyroid hormone signaling pathway, Proteoglycans in cancer	D00289	Danazol	[5] 60, 63, 64, 65, 285
8	ESR1	[3] Prolactin signaling pathway, Thyroid hormone signaling pathway, Proteoglycans in cancer	D00554	Ethinylestradiol	[4] 13, 46, 49, 299
9	ESR1	[3] Prolactin signaling pathway, Thyroid hormone signaling pathway, Proteoglycans in cancer	D00575	Mestranol	[2] 46, 49
10	ESR1	[3] Prolactin signaling pathway, Thyroid hormone signaling pathway, Proteoglycans in cancer	D01161	Fulvestrant	[2] 49, 86

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