Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	MAPK14	[56] Endocrine resistance, MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, S ...	D09639	Losmapimod	[2] 113, 222
2	MAPK14	[56] Endocrine resistance, MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, S ...	D10959	Neflamapimod	[1] 8
3	ACE	[6] Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease - COVID-19, Hyper ...	D00251	Captopril	[8] 6, 17, 46, 86, 96, 97, 107, 271
4	ACE	[6] Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease - COVID-19, Hyper ...	D00362	Lisinopril	[7] 19, 46, 49, 66, 67, 113, 222
5	ACE	[6] Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease - COVID-19, Hyper ...	D00421	Ramipril	[7] 46, 49, 66, 67, 113, 218, 257
6	ACE	[6] Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease - COVID-19, Hyper ...	D01069	Cilazapril	[1] 66
7	ACE	[6] Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease - COVID-19, Hyper ...	D03752	Quinapril	[1] 19
8	ACE	[6] Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease - COVID-19, Hyper ...	D03753	Perindopril	[4] 58, 113, 167, 222
9	ACE	[6] Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease - COVID-19, Hyper ...	D07499	Benazepril	[4] 49, 57, 218, 224
10	ACE	[6] Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease - COVID-19, Hyper ...	D07699	Cilazapril	[1] 66

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