Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	CPT1B	[7] Fatty acid degradation, Fatty acid metabolism, PPAR signaling pathway, Thermogenesis, Glucagon s ...	D08340	Perhexiline	[2] 58, 272
2	CPT2	[5] Fatty acid degradation, Fatty acid metabolism, PPAR signaling pathway, Thermogenesis, Diabetic c ...	D08340	Perhexiline	[2] 58, 272
3	PARP1	[3] NF-kappa B signaling pathway, Necroptosis, Diabetic cardiomyopathy	D09730	Olaparib	[2] 86, 285
4	MAPK14	[53] Endocrine resistance, MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, S ...	D09639	Losmapimod	[2] 113, 222
5	MAPK14	[53] Endocrine resistance, MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, S ...	D10959	Neflamapimod	[1] 8
6	ACE	[4] Renin-angiotensin system, Renin secretion, Hypertrophic cardiomyopathy, Diabetic cardiomyopathy	D00251	Captopril	[8] 6, 17, 46, 86, 96, 97, 107, 271
7	ACE	[4] Renin-angiotensin system, Renin secretion, Hypertrophic cardiomyopathy, Diabetic cardiomyopathy	D00362	Lisinopril	[7] 19, 46, 49, 66, 67, 113, 222
8	ACE	[4] Renin-angiotensin system, Renin secretion, Hypertrophic cardiomyopathy, Diabetic cardiomyopathy	D00421	Ramipril	[7] 46, 49, 66, 67, 113, 218, 257
9	ACE	[4] Renin-angiotensin system, Renin secretion, Hypertrophic cardiomyopathy, Diabetic cardiomyopathy	D01069	Cilazapril	[1] 66
10	ACE	[4] Renin-angiotensin system, Renin secretion, Hypertrophic cardiomyopathy, Diabetic cardiomyopathy	D03752	Quinapril	[1] 19

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