Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 MASP2 💬 [3] Complement and coagulation cascades, Staphylococcus aureus infection, Coronavirus disease - COVID-19 Narsoplimab 💬 Narsoplimab [4] 64, 66, 109, 222 💬
2 CFD 💬 [3] Complement and coagulation cascades, Staphylococcus aureus infection, Coronavirus disease - COVID-19 Danicopan 💬 Danicopan [1] 62 💬
3 F2 💬 [8] Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Platelet activation, Regulation of actin cytoskeleton, Pathogenic Escherichia coli infection, Coronavirus disease - COVID-19, Pathways in cancer Thrombomodulin alfa 💬 Thrombomodulin Alfa [1] 85 💬
4 F2 💬 [8] Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Platelet activation, Regulation of actin cytoskeleton, Pathogenic Escherichia coli infection, Coronavirus disease - COVID-19, Pathways in cancer Dabigatran etexilate 💬 Dabigatran etexilate [2] 51, 75 💬
5 F2 💬 [8] Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Platelet activation, Regulation of actin cytoskeleton, Pathogenic Escherichia coli infection, Coronavirus disease - COVID-19, Pathways in cancer Dabigatran 💬 Dabigatran [5] 51, 75, 85, 91, 124 💬
6 F8 💬 [1] Complement and coagulation cascades Desmopressin 💬 Desmopressin [6] 6, 64, 72, 75, 225, 288 💬
7 F9 💬 [1] Complement and coagulation cascades Emicizumab 💬 Emicizumab [1] 288 💬
8 F10 💬 [1] Complement and coagulation cascades Apixaban 💬 Apixaban [1] 222 💬
9 F10 💬 [1] Complement and coagulation cascades Rivaroxaban 💬 Rivaroxaban [4] 46, 49, 91, 210 💬
10 F10 💬 [1] Complement and coagulation cascades Edoxaban 💬 Edoxaban [2] 46, 88 💬
11 F10 💬 [1] Complement and coagulation cascades Emicizumab 💬 Emicizumab [1] 288 💬
12 SERPIND1 💬 [1] Complement and coagulation cascades Sulodexide 💬 Sulodexide [2] 51, 271 💬
13 KLKB1 💬 [1] Complement and coagulation cascades Conestat alfa 💬 Conestat alfa [1] 61 💬
14 SERPINC1 💬 [1] Complement and coagulation cascades Adomiparin 💬 Heparin [11] 47, 60, 70, 84, 107, 224, 226, 280, 299, 316, 317 💬
15 SERPINC1 💬 [1] Complement and coagulation cascades Adomiparin 💬 Enoxaparin [1] 46 💬
16 SERPINC1 💬 [1] Complement and coagulation cascades Adomiparin 💬 Parnaparin [1] 97 💬
17 SERPINC1 💬 [1] Complement and coagulation cascades Sulodexide 💬 Sulodexide [2] 51, 271 💬
18 PLG 💬 [4] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Staphylococcus aureus infection, Influenza A Aminocaproic acid 💬 Aminocaproic acid [1] 70 💬
19 PLG 💬 [4] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Staphylococcus aureus infection, Influenza A Tranexamic acid 💬 Tranexamic acid [7] 46, 70, 215, 227, 274, 288, 299 💬
20 CFB 💬 [3] Complement and coagulation cascades, Staphylococcus aureus infection, Coronavirus disease - COVID-19 Iptacopan 💬 Iptacopan [5] 61, 62, 66, 109, 222 💬
21 C1R 💬 [6] Phagosome, Complement and coagulation cascades, Pertussis, Staphylococcus aureus infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Conestat alfa 💬 Conestat alfa [1] 61 💬
22 C1S 💬 [5] Complement and coagulation cascades, Pertussis, Staphylococcus aureus infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Conestat alfa 💬 Conestat alfa [1] 61 💬
23 C1S 💬 [5] Complement and coagulation cascades, Pertussis, Staphylococcus aureus infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Sutimlimab 💬 Sutimlimab [1] 61 💬
24 C3 💬 [17] Neuroactive ligand-receptor interaction, Phagosome, Complement and coagulation cascades, Neutrophil extracellular trap formation, Alcoholic liver disease, Shigellosis, Pertussis, Legionellosis, Leishmaniasis, Chagas disease, Staphylococcus aureus infection, Tuberculosis, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Viral carcinogenesis, Systemic lupus erythematosus Pegcetacoplan 💬 Pegcetacoplan [4] 2, 61, 62, 222 💬
25 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Eculizumab 💬 Eculizumab [7] 11, 13, 14, 61, 62, 109, 222 💬
26 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Ravulizumab 💬 Ravulizumab [7] 2, 11, 13, 50, 62, 66, 109 💬
27 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Nomacopan 💬 Nomacopan [3] 62, 109, 162 💬
28 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Pozelimab 💬 Pozelimab [2] 11, 62 💬
29 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Crovalimab 💬 Crovalimab [2] 62, 109 💬
30 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Vilobelimab 💬 Vilobelimab [3] 43, 44, 269 💬
31 C5 💬 [11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus Zilucoplan 💬 Zilucoplan [3] 2, 11, 62 💬
32 C5AR1 💬 [6] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Alcoholic liver disease, Staphylococcus aureus infection, Coronavirus disease - COVID-19 Avacopan 💬 Avacopan [3] 43, 44, 222 💬
33 VWF 💬 [8] PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Complement and coagulation cascades, Platelet activation, Neutrophil extracellular trap formation, Human papillomavirus infection, Coronavirus disease - COVID-19 Caplacizumab 💬 Caplacizumab [1] 64 💬