Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	MTOR	22件: Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Longevit ...	D00753	Sirolimus	40件: 2, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, ...
2	MTOR	22件: Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Longevit ...	D02714	Everolimus	9件: 34, 67, 89, 96, 137, 157, 158, 228, 277
3	MTOR	22件: Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Longevit ...	D06068	Temsirolimus	1件: 13
4	INSR	13件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signalin ...	D03230	Insulin human	2件: 96, 156
5	INSR	13件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signalin ...	D03250	Insulin glargine	1件: 299
6	INSR	13件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signalin ...	D04539	Insulin detemir	1件: 299
7	PDE3B	7件: Purine metabolism, Metabolic pathways, Insulin signaling pathway, Progesterone-mediated oocyte m ...	D00227	Aminophylline	1件: 63
8	PDE3B	7件: Purine metabolism, Metabolic pathways, Insulin signaling pathway, Progesterone-mediated oocyte m ...	D00371	Theophylline	2件: 236, 299
9	PDE3B	7件: Purine metabolism, Metabolic pathways, Insulin signaling pathway, Progesterone-mediated oocyte m ...	D00417	Milrinone	1件: 294
10	PDE3B	7件: Purine metabolism, Metabolic pathways, Insulin signaling pathway, Progesterone-mediated oocyte m ...	D00528	Caffeine	8件: 2, 6, 21, 46, 78, 96, 97, 265

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