Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	EGFR	[14] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt sign ...	D01977	Gefitinib	[1] 75
2	EGFR	[14] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt sign ...	D03455	Cetuximab	[2] 51, 86
3	EGFR	[14] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt sign ...	D07907	Erlotinib	[1] 94
4	EGFR	[14] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt sign ...	D08108	Lapatinib	[3] 34, 74, 75
5	EGFR	[14] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt sign ...	D08950	Neratinib	[1] 34
6	EGFR	[14] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt sign ...	D11251	Icotinib	[1] 34
7	EGFR	[14] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt sign ...	D11772	Tesevatinib	[1] 67
8	GUCY1A2	[6] Purine metabolism, Vascular smooth muscle contraction, Platelet activation, Oxytocin signaling p ...	D00517	Amyl Nitrite	[1] 58
9	GUCY1A2	[6] Purine metabolism, Vascular smooth muscle contraction, Platelet activation, Oxytocin signaling p ...	D09572	Riociguat	[6] 51, 84, 86, 88, 225, 299
10	GUCY1A1	[6] Purine metabolism, Vascular smooth muscle contraction, Platelet activation, Oxytocin signaling p ...	D00517	Amyl Nitrite	[1] 58

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