Target Gene/Pathway Pathway / Gene

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KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[10] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap ...

Apomorphine 💬

[3] 5, 6, 7 💬

2

[10] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap ...

[4] 6, 7, 74, 299 💬

3

[8] Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap jun ...

Apomorphine 💬

[3] 5, 6, 7 💬

4

[8] Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap jun ...

[4] 6, 7, 74, 299 💬

5

[2] Neuroactive ligand-receptor interaction, Dopaminergic synapse

[4] 6, 7, 74, 299 💬

6

[2] Neuroactive ligand-receptor interaction, Dopaminergic synapse

[4] 6, 7, 74, 299 💬

7

[4] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Dopa ...

[4] 6, 7, 74, 299 💬

8

[4] MAPK signaling pathway, Alzheimer disease, Parkinson disease, Pathways of neurodegeneration - mu ...

Flortaucipir F 18 💬

[3] 5, 7, 127 💬

9

[20] cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, Sphingolipid s ...

[4] 2, 5, 7, 51 💬

10

[2] Synaptic vesicle cycle, Insulin secretion

Botulinum toxin type A 💬

Botulinum toxin type A

[14] 2, 5, 6, 7, 13, 15, 17, 36, 47, 51, 70, 113, 149, 226 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
5	Progressive supranuclear palsy
6	Parkinson disease
7	Corticobasal degeneration
13	Multiple sclerosis/Neuromyelitis optica
15	Inclusion body myositis
17	Multiple system atrophy
36	Epidermolysis bullosa
47	Buerger disease
51	Scleroderma
70	Spinal stenosis
113	Muscular dystrophy
149	Hemiconvulsion hemiplegia epilepsy syndrome
226	Interstitial cystitis with Hunners ulcer

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