Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	DHFR	5件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...	D00142	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
2	DHFR2	5件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...	D00142	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
3	IL1B	39件: Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa ...	D01583	Pirfenidone	11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
4	IL1B	39件: Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa ...	D06635	Rilonacept	4件: 51, 106, 107, 266
5	IL1B	39件: Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa ...	D09315	Canakinumab	10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269
6	IL1B	39件: Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa ...	D09911	Gevokizumab	4件: 41, 50, 56, 269
7	IL6	46件: EGFR tyrosine kinase inhibitor resistance, Antifolate resistance, Cytokine-cytokine receptor in ...	D01583	Pirfenidone	11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
8	IL6	46件: EGFR tyrosine kinase inhibitor resistance, Antifolate resistance, Cytokine-cytokine receptor in ...	D08976	Pomalidomide	5件: 28, 51, 85, 227, 331
9	IL6	46件: EGFR tyrosine kinase inhibitor resistance, Antifolate resistance, Cytokine-cytokine receptor in ...	D09669	Siltuximab	2件: 28, 331
10	IL6	46件: EGFR tyrosine kinase inhibitor resistance, Antifolate resistance, Cytokine-cytokine receptor in ...	D10080	Sirukumab	2件: 41, 46

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