Target Gene/Pathway Pathway / Gene


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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 ESR1 1件: Thyroid hormone signaling pathway D00105 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299
2 ESR1 1件: Thyroid hormone signaling pathway D00185 Estriol 2件: 13, 227
3 ESR1 1件: Thyroid hormone signaling pathway D00289 Danazol 5件: 60, 63, 64, 65, 285
4 ESR1 1件: Thyroid hormone signaling pathway D00554 Ethinylestradiol 4件: 13, 46, 49, 299
5 ESR1 1件: Thyroid hormone signaling pathway D00575 Mestranol 2件: 46, 49
6 ESR1 1件: Thyroid hormone signaling pathway D01161 Fulvestrant 2件: 49, 86
7 ESR1 1件: Thyroid hormone signaling pathway D01413 Estradiol valerate 1件: 65
8 ESR1 1件: Thyroid hormone signaling pathway D01986 Estriol 2件: 13, 227
9 ESR1 1件: Thyroid hormone signaling pathway D02367 Desogestrel 1件: 230
10 ESR1 1件: Thyroid hormone signaling pathway D07726 Clomifene 1件: 74
11 ESR1 1件: Thyroid hormone signaling pathway D08409 Prasterone 6件: 49, 53, 83, 86, 96, 113
12 ESR1 1件: Thyroid hormone signaling pathway D08465 Raloxifene 1件: 46
13 ESR1 1件: Thyroid hormone signaling pathway D08559 Tamoxifen 3件: 2, 113, 227
14 ESR1 1件: Thyroid hormone signaling pathway D11513 Estetrol 1件: 53
15 ESR1 1件: Thyroid hormone signaling pathway D11514 Estetrol 1件: 53
16 MTOR 2件: Thyroid hormone signaling pathway, Type II diabetes mellitus D00753 Sirolimus 40件: 2, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331
17 MTOR 2件: Thyroid hormone signaling pathway, Type II diabetes mellitus D02714 Everolimus 9件: 34, 67, 89, 96, 137, 157, 158, 228, 277
18 MTOR 2件: Thyroid hormone signaling pathway, Type II diabetes mellitus D06068 Temsirolimus 1件: 13
19 HDAC1 3件: Thyroid hormone signaling pathway, Transcriptional misregulation in cancer, Viral carcinogenesis D06320 Vorinostat 2件: 75, 96
20 HDAC2 3件: Thyroid hormone signaling pathway, Transcriptional misregulation in cancer, Viral carcinogenesis D06320 Vorinostat 2件: 75, 96
21 MYH7 2件: Thyroid hormone signaling pathway, Viral myocarditis D12265 Mavacamten 1件: 58
22 ATP1A1 2件: Thyroid hormone synthesis, Thyroid hormone signaling pathway D00297 Digitoxin 1件: 299
23 ATP1A1 2件: Thyroid hormone synthesis, Thyroid hormone signaling pathway D00298 Digoxin 3件: 8, 46, 210
24 ATP1A2 2件: Thyroid hormone synthesis, Thyroid hormone signaling pathway D00297 Digitoxin 1件: 299
25 ATP1A2 2件: Thyroid hormone synthesis, Thyroid hormone signaling pathway D00298 Digoxin 3件: 8, 46, 210
26 ATP1A3 2件: Thyroid hormone synthesis, Thyroid hormone signaling pathway D00297 Digitoxin 1件: 299
27 ATP1A3 2件: Thyroid hormone synthesis, Thyroid hormone signaling pathway D00298 Digoxin 3件: 8, 46, 210
28 ATP1A4 2件: Thyroid hormone synthesis, Thyroid hormone signaling pathway D00297 Digitoxin 1件: 299
29 ATP1A4 2件: Thyroid hormone synthesis, Thyroid hormone signaling pathway D00298 Digoxin 3件: 8, 46, 210
30 PIK3CA 7件: VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11011 Alpelisib 1件: 138
31 PIK3CA 7件: VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11158 Leniolisib 2件: 53, 65
32 PIK3CB 7件: VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11158 Leniolisib 2件: 53, 65
33 PIK3CD 7件: VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11158 Leniolisib 2件: 53, 65
34 PIK3CD 7件: VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11437 Parsaclisib 3件: 35, 53, 61
35 PRKCB 5件: Vascular smooth muscle contraction, Wnt signaling pathway, VEGF signaling pathway, Thyroid hormone synthesis, Thyroid hormone signaling pathway D11935 Enzastaurin 1件: 168
36 MAP2K1 6件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Yersinia infection D09666 Selumetinib 1件: 34
37 MAP2K1 6件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Yersinia infection D10175 Trametinib 4件: 2, 34, 279, 280
38 MAP2K1 6件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Yersinia infection D10405 Cobimetinib 1件: 280
39 MAP2K1 6件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Yersinia infection D10604 Binimetinib 1件: 34
40 MAP2K1 6件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Yersinia infection D11675 Mirdametinib 1件: 34
41 MAP2K2 5件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Thyroid hormone signaling pathway, Yersinia infection D09666 Selumetinib 1件: 34
42 MAP2K2 5件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Thyroid hormone signaling pathway, Yersinia infection D10175 Trametinib 4件: 2, 34, 279, 280
43 MAP2K2 5件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Thyroid hormone signaling pathway, Yersinia infection D10405 Cobimetinib 1件: 280
44 MAP2K2 5件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Thyroid hormone signaling pathway, Yersinia infection D10604 Binimetinib 1件: 34
45 MAP2K2 5件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Thyroid hormone signaling pathway, Yersinia infection D11675 Mirdametinib 1件: 34
46 RAF1 4件: Vascular smooth muscle contraction, VEGF signaling pathway, Thyroid hormone signaling pathway, Tuberculosis D08524 Sorafenib 2件: 34, 86
47 RXRA 2件: Thyroid hormone signaling pathway, Transcriptional misregulation in cancer D02754 Acitretin 1件: 37
48 RXRA 2件: Thyroid hormone signaling pathway, Transcriptional misregulation in cancer D02815 Alitretinoin 1件: 49
49 RXRA 2件: Thyroid hormone signaling pathway, Transcriptional misregulation in cancer D03106 Bexarotene 2件: 13, 75
50 RXRB 2件: Thyroid hormone signaling pathway, Transcriptional misregulation in cancer D02754 Acitretin 1件: 37
51 RXRB 2件: Thyroid hormone signaling pathway, Transcriptional misregulation in cancer D02815 Alitretinoin 1件: 49
52 RXRB 2件: Thyroid hormone signaling pathway, Transcriptional misregulation in cancer D03106 Bexarotene 2件: 13, 75
53 RXRG 2件: Thyroid hormone signaling pathway, Transcriptional misregulation in cancer D02754 Acitretin 1件: 37
54 RXRG 2件: Thyroid hormone signaling pathway, Transcriptional misregulation in cancer D02815 Alitretinoin 1件: 49
55 RXRG 2件: Thyroid hormone signaling pathway, Transcriptional misregulation in cancer D03106 Bexarotene 2件: 13, 75
56 SRC 6件: VEGF signaling pathway, Tight junction, Thyroid hormone signaling pathway, Yersinia infection, Tuberculosis, Viral carcinogenesis D03252 Bosutinib 2件: 2, 67
57 SRC 6件: VEGF signaling pathway, Tight junction, Thyroid hormone signaling pathway, Yersinia infection, Tuberculosis, Viral carcinogenesis D03658 Dasatinib 2件: 51, 85
58 SRC 6件: VEGF signaling pathway, Tight junction, Thyroid hormone signaling pathway, Yersinia infection, Tuberculosis, Viral carcinogenesis D06414 Dasatinib 2件: 51, 85
59 SRC 6件: VEGF signaling pathway, Tight junction, Thyroid hormone signaling pathway, Yersinia infection, Tuberculosis, Viral carcinogenesis D09664 Saracatinib 3件: 6, 89, 272
60 THRA 1件: Thyroid hormone signaling pathway D07214 Tiratricol 2件: 78, 139
61 THRA 1件: Thyroid hormone signaling pathway D08125 Levothyroxine 5件: 19, 49, 78, 80, 222
62 THRA 1件: Thyroid hormone signaling pathway D08128 Liothyronine 4件: 13, 78, 210, 212
63 THRB 1件: Thyroid hormone signaling pathway D07214 Tiratricol 2件: 78, 139
64 THRB 1件: Thyroid hormone signaling pathway D08125 Levothyroxine 5件: 19, 49, 78, 80, 222
65 THRB 1件: Thyroid hormone signaling pathway D08128 Liothyronine 4件: 13, 78, 210, 212
66 THRB 1件: Thyroid hormone signaling pathway D09381 Sobetirome 1件: 20
67 CASP9 5件: VEGF signaling pathway, Thyroid hormone signaling pathway, Toxoplasmosis, Tuberculosis, Viral myocarditis D11195 Rimiducid 6件: 19, 60, 65, 284, 285, 326
68 HDAC3 2件: Thyroid hormone signaling pathway, Viral carcinogenesis D06320 Vorinostat 2件: 75, 96