Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 CHRM1 1件: Regulation of actin cytoskeleton D00113 Atropine 2件: 2, 299
2 CHRM1 1件: Regulation of actin cytoskeleton D00138 Scopolamine 1件: 2
3 CHRM1 1件: Regulation of actin cytoskeleton D00270 Chlorpromazine 1件: 254
4 CHRM1 1件: Regulation of actin cytoskeleton D00397 Tropicamide 1件: 6
5 CHRM1 1件: Regulation of actin cytoskeleton D00465 Oxybutynin 3件: 6, 13, 53
6 CHRM1 1件: Regulation of actin cytoskeleton D08441 Propiverine 1件: 226
7 CHRM1 1件: Regulation of actin cytoskeleton D08638 Trihexyphenidyl 2件: 5, 6
8 CHRM1 1件: Regulation of actin cytoskeleton D11383 Blarcamesine 1件: 156
9 CHRM2 1件: Regulation of actin cytoskeleton D00113 Atropine 2件: 2, 299
10 CHRM2 1件: Regulation of actin cytoskeleton D00138 Scopolamine 1件: 2
11 CHRM2 1件: Regulation of actin cytoskeleton D00270 Chlorpromazine 1件: 254
12 CHRM2 1件: Regulation of actin cytoskeleton D00397 Tropicamide 1件: 6
13 CHRM2 1件: Regulation of actin cytoskeleton D00465 Oxybutynin 3件: 6, 13, 53
14 CHRM2 1件: Regulation of actin cytoskeleton D00525 Pilocarpine 3件: 6, 53, 299
15 CHRM2 1件: Regulation of actin cytoskeleton D07226 Fesoterodine 1件: 6
16 CHRM2 1件: Regulation of actin cytoskeleton D08441 Propiverine 1件: 226
17 CHRM2 1件: Regulation of actin cytoskeleton D08638 Trihexyphenidyl 2件: 5, 6
18 CHRM2 1件: Regulation of actin cytoskeleton D11383 Blarcamesine 1件: 156
19 CHRM3 3件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D00113 Atropine 2件: 2, 299
20 CHRM3 3件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D00138 Scopolamine 1件: 2
21 CHRM3 3件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D00270 Chlorpromazine 1件: 254
22 CHRM3 3件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D00397 Tropicamide 1件: 6
23 CHRM3 3件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D00465 Oxybutynin 3件: 6, 13, 53
24 CHRM3 3件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D00525 Pilocarpine 3件: 6, 53, 299
25 CHRM3 3件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D00646 Tolterodine 2件: 17, 53
26 CHRM3 3件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D03654 Darifenacin 2件: 6, 13
27 CHRM3 3件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D07226 Fesoterodine 1件: 6
28 CHRM3 3件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D07667 Cevimeline 1件: 53
29 CHRM3 3件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D08441 Propiverine 1件: 226
30 CHRM3 3件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D08522 Solifenacin 3件: 6, 13, 53
31 CHRM3 3件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D08638 Trihexyphenidyl 2件: 5, 6
32 CHRM3 3件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion D11383 Blarcamesine 1件: 156
33 CHRM4 1件: Regulation of actin cytoskeleton D00113 Atropine 2件: 2, 299
34 CHRM4 1件: Regulation of actin cytoskeleton D00138 Scopolamine 1件: 2
35 CHRM4 1件: Regulation of actin cytoskeleton D00270 Chlorpromazine 1件: 254
36 CHRM4 1件: Regulation of actin cytoskeleton D00397 Tropicamide 1件: 6
37 CHRM4 1件: Regulation of actin cytoskeleton D00465 Oxybutynin 3件: 6, 13, 53
38 CHRM4 1件: Regulation of actin cytoskeleton D08441 Propiverine 1件: 226
39 CHRM4 1件: Regulation of actin cytoskeleton D08638 Trihexyphenidyl 2件: 5, 6
40 CHRM4 1件: Regulation of actin cytoskeleton D11383 Blarcamesine 1件: 156
41 CHRM5 1件: Regulation of actin cytoskeleton D00113 Atropine 2件: 2, 299
42 CHRM5 1件: Regulation of actin cytoskeleton D00138 Scopolamine 1件: 2
43 CHRM5 1件: Regulation of actin cytoskeleton D00270 Chlorpromazine 1件: 254
44 CHRM5 1件: Regulation of actin cytoskeleton D00397 Tropicamide 1件: 6
45 CHRM5 1件: Regulation of actin cytoskeleton D00465 Oxybutynin 3件: 6, 13, 53
46 CHRM5 1件: Regulation of actin cytoskeleton D08441 Propiverine 1件: 226
47 CHRM5 1件: Regulation of actin cytoskeleton D08638 Trihexyphenidyl 2件: 5, 6
48 CHRM5 1件: Regulation of actin cytoskeleton D11383 Blarcamesine 1件: 156
49 EGFR 3件: Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D01977 Gefitinib 1件: 75
50 EGFR 3件: Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D03455 Cetuximab 2件: 51, 86
51 EGFR 3件: Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D07907 Erlotinib 1件: 94
52 EGFR 3件: Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D08108 Lapatinib 3件: 34, 74, 75
53 EGFR 3件: Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D08950 Neratinib 1件: 34
54 EGFR 3件: Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D11251 Icotinib 1件: 34
55 EGFR 3件: Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D11772 Tesevatinib 1件: 67
56 F2 1件: Regulation of actin cytoskeleton D06410 Thrombomodulin Alfa 1件: 85
57 F2 1件: Regulation of actin cytoskeleton D07144 Dabigatran etexilate 2件: 51, 75
58 F2 1件: Regulation of actin cytoskeleton D09707 Dabigatran 5件: 51, 75, 85, 91, 124
59 FGFR1 3件: Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton D10481 Nintedanib 5件: 51, 85, 89, 227, 228
60 FGFR1 3件: Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton D11589 Infigratinib 1件: 276
61 FGFR3 2件: Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D10481 Nintedanib 5件: 51, 85, 89, 227, 228
62 FGFR3 2件: Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D11589 Infigratinib 1件: 276
63 FGFR2 2件: Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D05338 Palifermin 5件: 13, 36, 38, 39, 65
64 FGFR2 2件: Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D10481 Nintedanib 5件: 51, 85, 89, 227, 228
65 FGFR2 2件: Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D11589 Infigratinib 1件: 276
66 ITGA4 2件: Regulation of actin cytoskeleton, Yersinia infection D06590 Firategrast 1件: 13
67 ITGA4 2件: Regulation of actin cytoskeleton, Yersinia infection D06886 Natalizumab 6件: 13, 15, 25, 46, 63, 96
68 ITGA4 2件: Regulation of actin cytoskeleton, Yersinia infection D08083 Vedolizumab 3件: 94, 96, 97
69 ITGA4 2件: Regulation of actin cytoskeleton, Yersinia infection D10540 Abrilumab 2件: 96, 97
70 ITGAL 4件: Regulation of actin cytoskeleton, Staphylococcus aureus infection, Rheumatoid arthritis, Viral myocarditis D03959 Efalizumab 9件: 11, 13, 37, 46, 49, 53, 61, 95, 96
71 ITGB7 2件: Regulation of actin cytoskeleton, Transcriptional misregulation in cancer D08083 Vedolizumab 3件: 94, 96, 97
72 ITGB7 2件: Regulation of actin cytoskeleton, Transcriptional misregulation in cancer D09901 Etrolizumab 2件: 96, 97
73 ITGB7 2件: Regulation of actin cytoskeleton, Transcriptional misregulation in cancer D10540 Abrilumab 2件: 96, 97
74 PDGFRA 1件: Regulation of actin cytoskeleton D08066 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
75 PDGFRA 1件: Regulation of actin cytoskeleton D08552 Sunitinib 2件: 28, 34
76 PDGFRA 1件: Regulation of actin cytoskeleton D08953 Nilotinib 5件: 6, 8, 34, 51, 86
77 PDGFRA 1件: Regulation of actin cytoskeleton D10481 Nintedanib 5件: 51, 85, 89, 227, 228
78 PDGFRB 1件: Regulation of actin cytoskeleton D03658 Dasatinib 2件: 51, 85
79 PDGFRB 1件: Regulation of actin cytoskeleton D06414 Dasatinib 2件: 51, 85
80 PDGFRB 1件: Regulation of actin cytoskeleton D08524 Sorafenib 2件: 34, 86
81 PDGFRB 1件: Regulation of actin cytoskeleton D08552 Sunitinib 2件: 28, 34
82 PDGFRB 1件: Regulation of actin cytoskeleton D08953 Nilotinib 5件: 6, 8, 34, 51, 86
83 PDGFRB 1件: Regulation of actin cytoskeleton D10481 Nintedanib 5件: 51, 85, 89, 227, 228
84 PIK3CA 18件: Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11011 Alpelisib 1件: 138
85 PIK3CA 18件: Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11158 Leniolisib 2件: 53, 65
86 PIK3CB 18件: Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11158 Leniolisib 2件: 53, 65
87 PIK3CD 18件: Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11158 Leniolisib 2件: 53, 65
88 PIK3CD 18件: Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11437 Parsaclisib 3件: 35, 53, 61
89 MAP2K1 15件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D09666 Selumetinib 1件: 34
90 MAP2K1 15件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10175 Trametinib 4件: 2, 34, 279, 280
91 MAP2K1 15件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10405 Cobimetinib 1件: 280
92 MAP2K1 15件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10604 Binimetinib 1件: 34
93 MAP2K1 15件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D11675 Mirdametinib 1件: 34
94 MAP2K2 13件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D09666 Selumetinib 1件: 34
95 MAP2K2 13件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10175 Trametinib 4件: 2, 34, 279, 280
96 MAP2K2 13件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10405 Cobimetinib 1件: 280
97 MAP2K2 13件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10604 Binimetinib 1件: 34
98 MAP2K2 13件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D11675 Mirdametinib 1件: 34
99 RAF1 12件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, T cell receptor signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Tuberculosis, Renal cell carcinoma D08524 Sorafenib 2件: 34, 86
100 ROCK1 7件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, TGF-beta signaling pathway, Tight junction, Regulation of actin cytoskeleton, Shigellosis, Yersinia infection D07941 Fasudil 4件: 2, 5, 7, 51
101 SRC 9件: VEGF signaling pathway, Tight junction, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D03252 Bosutinib 2件: 2, 67
102 SRC 9件: VEGF signaling pathway, Tight junction, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D03658 Dasatinib 2件: 51, 85
103 SRC 9件: VEGF signaling pathway, Tight junction, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D06414 Dasatinib 2件: 51, 85
104 SRC 9件: VEGF signaling pathway, Tight junction, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D09664 Saracatinib 3件: 6, 89, 272
105 BRAF 5件: Vascular smooth muscle contraction, Serotonergic synapse, Regulation of actin cytoskeleton, Renal cell carcinoma, Thyroid cancer D08524 Sorafenib 2件: 34, 86
106 BRAF 5件: Vascular smooth muscle contraction, Serotonergic synapse, Regulation of actin cytoskeleton, Renal cell carcinoma, Thyroid cancer D10064 Dabrafenib 1件: 34
107 C5 3件: Regulation of actin cytoskeleton, Staphylococcus aureus infection, Systemic lupus erythematosus D03940 Eculizumab 7件: 11, 13, 14, 61, 62, 109, 222
108 C5 3件: Regulation of actin cytoskeleton, Staphylococcus aureus infection, Systemic lupus erythematosus D11054 Ravulizumab 7件: 2, 11, 13, 50, 62, 66, 109
109 C5 3件: Regulation of actin cytoskeleton, Staphylococcus aureus infection, Systemic lupus erythematosus D11473 Nomacopan 3件: 62, 109, 162
110 C5 3件: Regulation of actin cytoskeleton, Staphylococcus aureus infection, Systemic lupus erythematosus D11477 Pozelimab 2件: 11, 62
111 C5 3件: Regulation of actin cytoskeleton, Staphylococcus aureus infection, Systemic lupus erythematosus D11696 Crovalimab 2件: 62, 109
112 C5 3件: Regulation of actin cytoskeleton, Staphylococcus aureus infection, Systemic lupus erythematosus D11838 Vilobelimab 3件: 43, 44, 269
113 C5 3件: Regulation of actin cytoskeleton, Staphylococcus aureus infection, Systemic lupus erythematosus D12357 Zilucoplan 3件: 2, 11, 62
114 CXCR4 4件: Viral life cycle - HIV-1, Virion - Human immunodeficiency virus, Viral protein interaction with cytokine and cytokine receptor, Regulation of actin cytoskeleton D08971 Plerixafor 5件: 19, 20, 65, 285, 299
115 FGF23 1件: Regulation of actin cytoskeleton D10913 Burosumab 1件: 238
116 ROCK2 8件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, Tight junction, Regulation of actin cytoskeleton, Shigellosis, Salmonella infection, Yersinia infection D07941 Fasudil 4件: 2, 5, 7, 51
117 ROCK2 8件: Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, Tight junction, Regulation of actin cytoskeleton, Shigellosis, Salmonella infection, Yersinia infection D11815 Belumosudil 2件: 51, 85