Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	MAPK14	47件: MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling ...	D09639	Losmapimod	2件: 113, 222
2	MAPK14	47件: MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling ...	D10959	Neflamapimod	1件: 8
3	NQO1	5件: Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, Pathways in cancer, Hep ...	D08682	Warfarin	11件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91
4	HMOX1	8件: Porphyrin metabolism, Metabolic pathways, HIF-1 signaling pathway, Mineral absorption, Pathways ...	D05922	Stannsoporfin	1件: 254
5	IFNG	26件: Proteasome, HIF-1 signaling pathway, Necroptosis, TGF-beta signaling pathway, Osteoclast differ ...	D04242	Fontolizumab	1件: 46
6	IFNG	26件: Proteasome, HIF-1 signaling pathway, Necroptosis, TGF-beta signaling pathway, Osteoclast differ ...	D11120	Emapalumab	3件: 49, 65, 107
7	IL1A	17件: MAPK signaling pathway, Necroptosis, Osteoclast differentiation, Hematopoietic cell lineage, No ...	D01583	Pirfenidone	11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
8	IL1A	17件: MAPK signaling pathway, Necroptosis, Osteoclast differentiation, Hematopoietic cell lineage, No ...	D06635	Rilonacept	4件: 51, 106, 107, 266
9	IL1A	17件: MAPK signaling pathway, Necroptosis, Osteoclast differentiation, Hematopoietic cell lineage, No ...	D11253	Bermekimab	1件: 51
10	IL1B	33件: MAPK signaling pathway, NF-kappa B signaling pathway, Necroptosis, Osteoclast differentiation, ...	D01583	Pirfenidone	11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228

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