Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	IL17F	[1] Th17 cell differentiation	D11550	Bimekizumab	[3] 46, 97, 271
2	MAPK14	[8] VEGF signaling pathway, Toll-like receptor signaling pathway, Th17 cell differentiation, TNF sig ...	D09639	Losmapimod	[2] 113, 222
3	MAPK14	[8] VEGF signaling pathway, Toll-like receptor signaling pathway, Th17 cell differentiation, TNF sig ...	D10959	Neflamapimod	[1] 8
4	MTOR	[4] Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes me ...	D00753	Sirolimus	[40] 2, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, ...
5	MTOR	[4] Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes me ...	D02714	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277
6	MTOR	[4] Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes me ...	D06068	Temsirolimus	[1] 13
7	IFNG	[4] Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis	D04242	Fontolizumab	[1] 46
8	IFNG	[4] Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis	D11120	Emapalumab	[3] 49, 65, 107
9	IFNGR1	[3] Th17 cell differentiation, Toxoplasmosis, Tuberculosis	D00747	Interferon gamma-1b	[7] 18, 65, 85, 228, 299, 301, 326
10	IFNGR2	[3] Th17 cell differentiation, Toxoplasmosis, Tuberculosis	D00747	Interferon gamma-1b	[7] 18, 65, 85, 228, 299, 301, 326

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