Target Gene/Pathway Pathway / Gene

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KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[5] Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Intestinal immune network ...

[7] 35, 46, 49, 53, 61, 63, 95 💬

2

[12] Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine re ...

Aldesleukin 💬

[6] 2, 35, 49, 65, 96, 97 💬

3

[15] Chemokine signaling pathway, PI3K-Akt signaling pathway, Necroptosis, Signaling pathways regula ...

Tofacitinib 💬

[15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬

Disease ID	Name
11	Myasthenia gravis
40	Takayasu arteritis
44	Wegener granulomatosis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
50	Dermatomyositis
51	Scleroderma
53	Sjogren syndrome
65	Primary immunodeficiency
84	Sarcoidosis
96	Crohn disease
97	Ulcerative colitis
107	Juvenile idiopathic arthritis
271	Ankylosing spondylitis
300	IgG4-related disease

4

[15] Chemokine signaling pathway, PI3K-Akt signaling pathway, Necroptosis, Signaling pathways regula ...

Peficitinib 💬

[1] 46 💬

5

[10] NF-kappa B signaling pathway, Osteoclast differentiation, Natural killer cell mediated cytotoxi ...

[2] 51, 85 💬

6

[10] NF-kappa B signaling pathway, Osteoclast differentiation, Natural killer cell mediated cytotoxi ...

[2] 51, 85 💬

7

[7] NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, B cell receptor s ...

[3] 28, 60, 61 💬

8

[7] NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, B cell receptor s ...

Acalabrutinib 💬

[2] 46, 61 💬

9

[7] NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, B cell receptor s ...

Zanubrutinib 💬

[5] 13, 63, 222, 300, 331 💬

10

[7] NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, B cell receptor s ...

Fenebrutinib 💬

[1] 13 💬

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