Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	MAPK14	44件: MAPK signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Oocyte meiosis, ...	D09639	Losmapimod	2件: 113, 222
2	MAPK14	44件: MAPK signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Oocyte meiosis, ...	D10959	Neflamapimod	1件: 8
3	MTOR	31件: HIF-1 signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt si ...	D00753	Sirolimus	40件: 2, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, ...
4	MTOR	31件: HIF-1 signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt si ...	D02714	Everolimus	9件: 34, 67, 89, 96, 137, 157, 158, 228, 277
5	MTOR	31件: HIF-1 signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt si ...	D06068	Temsirolimus	1件: 13
6	GHR	4件: Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, ...	D03297	Mecasermin	6件: 65, 78, 96, 168, 265, 299
7	GHR	4件: Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, ...	D05394	Pegvisomant	2件: 78, 265
8	GHR	4件: Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, ...	D11193	Somavaratan	1件: 78
9	GHR	4件: Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, ...	D11194	Somapacitan	2件: 78, 195
10	GHR	4件: Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, ...	D11486	Lonapegsomatropin	1件: 78

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