Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	CDK4	[16] p53 signaling pathway, PI3K-Akt signaling pathway, Tight junction, T cell receptor signaling pa ...	D10688	Abemaciclib	[1] 34
2	CDK6	[14] p53 signaling pathway, PI3K-Akt signaling pathway, Measles, Human cytomegalovirus infection, In ...	D10688	Abemaciclib	[1] 34
3	CCR5	[8] Viral life cycle - HIV-1, Virion - Human immunodeficiency virus, Viral protein interaction with ...	D06670	Maraviroc	[2] 46, 84
4	CCR5	[8] Viral life cycle - HIV-1, Virion - Human immunodeficiency virus, Viral protein interaction with ...	D09878	Cenicriviroc	[1] 94
5	MAPK14	[42] MAPK signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Oocyte meiosis, ...	D09639	Losmapimod	[2] 113, 222
6	MAPK14	[42] MAPK signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Oocyte meiosis, ...	D10959	Neflamapimod	[1] 8
7	EGFR	[21] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signalin ...	D01977	Gefitinib	[1] 75
8	EGFR	[21] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signalin ...	D03455	Cetuximab	[2] 51, 86
9	EGFR	[21] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signalin ...	D07907	Erlotinib	[1] 94
10	EGFR	[21] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signalin ...	D08108	Lapatinib	[3] 34, 74, 75

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