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KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
Disease ID
1
IFNG
💬
1. IFNG
×
Name
Full Name
IFNG
interferon gamma
[32]
Proteasome
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Antigen processing and presentation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Type I diabetes mellitus
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis C
,
Influenza A
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
,
Allograft rejection
,
Graft-versus-host disease
,
Fluid shear stress and atherosclerosis
[32]
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-b
...
Fontolizumab
Fontolizumab
💬
1. IFNG
×
Name
Other Names
Fontolizumab
Fontolizumab (USAN/INN)
Fontolizumab
[1]
46
46
💬
1. IFNG
×
Disease ID
Name
46
Malignant rheumatoid arthritis
2
IFNG
💬
2. IFNG
×
Name
Full Name
IFNG
interferon gamma
[32]
Proteasome
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Antigen processing and presentation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Type I diabetes mellitus
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis C
,
Influenza A
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
,
Allograft rejection
,
Graft-versus-host disease
,
Fluid shear stress and atherosclerosis
[32]
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-b
...
Emapalumab
Emapalumab
💬
2. IFNG
×
Name
Other Names
Emapalumab
Emapalumab (USAN/INN)
Emapalumab (genetical recombination) (JAN)
Emapalumab-lzsg
Gamifant (TN)
Emapalumab
[3]
49
49
,
65
,
107
💬
2. IFNG
×
Disease ID
Name
49
Systemic lupus erythematosus
65
Primary immunodeficiency
107
Juvenile idiopathic arthritis
3
IL4
💬
3. IL4
×
Name
Full Name
IL4
interleukin 4
[16]
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
PI3K-Akt signaling pathway
,
JAK-STAT signaling pathway
,
Hematopoietic cell lineage
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Intestinal immune network for IgA production
,
Leishmaniasis
,
Pathways in cancer
,
Asthma
,
Autoimmune thyroid disease
,
Inflammatory bowel disease
,
Allograft rejection
[16]
Cytokine-cytokine receptor interaction
,
PI3K-Akt signaling pathway
,
JAK-STAT signaling pathway
, ...
Binetrakin
Binetrakin
💬
3. IL4
×
Name
Other Names
Binetrakin
Binetrakin (USAN/INN)
Binetrakin
[1]
46
46
💬
3. IL4
×
Disease ID
Name
46
Malignant rheumatoid arthritis
4
IL5
💬
4. IL5
×
Name
Full Name
IL5
interleukin 5
[13]
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
JAK-STAT signaling pathway
,
Hematopoietic cell lineage
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Intestinal immune network for IgA production
,
Pathways in cancer
,
Asthma
,
Autoimmune thyroid disease
,
Inflammatory bowel disease
,
Allograft rejection
[13]
Cytokine-cytokine receptor interaction
,
JAK-STAT signaling pathway
,
Hematopoietic cell lineage
, ...
Mepolizumab
Mepolizumab
💬
4. IL5
×
Name
Other Names
Mepolizumab
Mepolizumab (USAN/INN)
Mepolizumab (genetical recombination) (JAN)
Nucala (TN)
Mepolizumab
[4]
44
44
,
45
,
98
,
162
💬
4. IL5
×
Disease ID
Name
44
Wegener granulomatosis
45
Eosinophilic granulomatosis with Polyangiitis
98
Eosinophilic gastrointestinal disease
162
Pemphigoid
5
IL5
💬
5. IL5
×
Name
Full Name
IL5
interleukin 5
[13]
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
JAK-STAT signaling pathway
,
Hematopoietic cell lineage
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Intestinal immune network for IgA production
,
Pathways in cancer
,
Asthma
,
Autoimmune thyroid disease
,
Inflammatory bowel disease
,
Allograft rejection
[13]
Cytokine-cytokine receptor interaction
,
JAK-STAT signaling pathway
,
Hematopoietic cell lineage
, ...
Reslizumab
Reslizumab
💬
5. IL5
×
Name
Other Names
Reslizumab
Reslizumab (USAN)
Cinqaero (TN)
Cinqair (TN)
Reslizumab
[2]
44
44
,
98
💬
5. IL5
×
Disease ID
Name
44
Wegener granulomatosis
98
Eosinophilic gastrointestinal disease
6
IL10
💬
6. IL10
×
Name
Full Name
IL10
interleukin 10
[22]
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
Viral protein interaction with cytokine and cytokine receptor
,
FoxO signaling pathway
,
C-type lectin receptor signaling pathway
,
JAK-STAT signaling pathway
,
T cell receptor signaling pathway
,
Intestinal immune network for IgA production
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Staphylococcus aureus infection
,
Tuberculosis
,
Asthma
,
Autoimmune thyroid disease
,
Inflammatory bowel disease
,
Systemic lupus erythematosus
,
Allograft rejection
[22]
Cytokine-cytokine receptor interaction
,
Viral protein interaction with cytokine and cytokine re
...
Pirfenidone
Pirfenidone
💬
6. IL10
×
Name
Other Names
Pirfenidone
Pirfenidone (JAN/USAN/INN)
Esbriet (TN)
Pirfenidone
[11]
13
13
,
34
,
46
,
50
,
51
,
58
,
84
,
85
,
164
,
222
,
228
💬
6. IL10
×
Disease ID
Name
13
Multiple sclerosis/Neuromyelitis optica
34
Neurofibromatosis
46
Malignant rheumatoid arthritis
50
Dermatomyositis
51
Scleroderma
58
Hypertrophic cardiomyopathy
84
Sarcoidosis
85
Idiopathic interstitial pneumonia
164
Oculocutaneous albinism
222
Primary nephrotic syndrome
228
Bronchiolitis obliterans
7
IL12A
💬
7. IL12A
×
Name
Full Name
IL12A
interleukin 12A
[25]
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
Toll-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
JAK-STAT signaling pathway
,
Th1 and Th2 cell differentiation
,
Alcoholic liver disease
,
Type I diabetes mellitus
,
Pertussis
,
Legionellosis
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Measles
,
Influenza A
,
Herpes simplex virus 1 infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Inflammatory bowel disease
,
Allograft rejection
,
Lipid and atherosclerosis
[25]
Cytokine-cytokine receptor interaction
,
Toll-like receptor signaling pathway
,
RIG-I-like recept
...
Ustekinumab
Ustekinumab
💬
7. IL12A
×
Name
Other Names
Ustekinumab
Ustekinumab (USAN/INN)
Ustekinumab (genetical recombination) (JAN)
Stelara (TN)
Ustekinumab
[16]
37
37
,
40
,
41
,
46
,
49
,
50
,
56
,
65
,
84
,
93
,
96
,
97
,
160
,
162
,
269
,
271
💬
7. IL12A
×
Disease ID
Name
37
Generalised pustular psoriasis
40
Takayasu arteritis
41
Giant cell arteritis
46
Malignant rheumatoid arthritis
49
Systemic lupus erythematosus
50
Dermatomyositis
56
Behcet disease
65
Primary immunodeficiency
84
Sarcoidosis
93
Primary biliary cholangitis
96
Crohn disease
97
Ulcerative colitis
160
Congenital ichthyosis
162
Pemphigoid
269
Pyogenic arthritis
271
Ankylosing spondylitis
8
IL12B
💬
8. IL12B
×
Name
Full Name
IL12B
interleukin 12B
[25]
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
Toll-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
JAK-STAT signaling pathway
,
Th1 and Th2 cell differentiation
,
Alcoholic liver disease
,
Type I diabetes mellitus
,
Pertussis
,
Legionellosis
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Measles
,
Influenza A
,
Herpes simplex virus 1 infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Proteoglycans in cancer
,
Inflammatory bowel disease
,
Allograft rejection
,
Lipid and atherosclerosis
[25]
Cytokine-cytokine receptor interaction
,
Toll-like receptor signaling pathway
,
RIG-I-like recept
...
Ustekinumab
Ustekinumab
💬
8. IL12B
×
Name
Other Names
Ustekinumab
Ustekinumab (USAN/INN)
Ustekinumab (genetical recombination) (JAN)
Stelara (TN)
Ustekinumab
[16]
37
37
,
40
,
41
,
46
,
49
,
50
,
56
,
65
,
84
,
93
,
96
,
97
,
160
,
162
,
269
,
271
💬
8. IL12B
×
Disease ID
Name
37
Generalised pustular psoriasis
40
Takayasu arteritis
41
Giant cell arteritis
46
Malignant rheumatoid arthritis
49
Systemic lupus erythematosus
50
Dermatomyositis
56
Behcet disease
65
Primary immunodeficiency
84
Sarcoidosis
93
Primary biliary cholangitis
96
Crohn disease
97
Ulcerative colitis
160
Congenital ichthyosis
162
Pemphigoid
269
Pyogenic arthritis
271
Ankylosing spondylitis
9
TNF
💬
9. TNF
×
Name
Full Name
TNF
tumor necrosis factor
[67]
Antifolate resistance
Antifolate resistance
,
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Viral protein interaction with cytokine and cytokine receptor
,
NF-kappa B signaling pathway
,
Sphingolipid signaling pathway
,
mTOR signaling pathway
,
Apoptosis
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Antigen processing and presentation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
Hematopoietic cell lineage
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Adipocytokine signaling pathway
,
Type II diabetes mellitus
,
Insulin resistance
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Alcoholic liver disease
,
Type I diabetes mellitus
,
Alzheimer disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Legionellosis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis C
,
Hepatitis B
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Herpes simplex virus 1 infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Asthma
,
Inflammatory bowel disease
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
,
Allograft rejection
,
Graft-versus-host disease
,
Hypertrophic cardiomyopathy
,
Dilated cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[67]
Antifolate resistance
,
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Viral pr
...
Etanercept
Etanercept
💬
9. TNF
×
Name
Other Names
Etanercept
Etanercept (USAN/INN)
Etanercept (genetical recombination) (JAN)
Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN)
Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN)
Enbrel (TN)
Etanercept
[16]
15
15
,
28
,
35
,
38
,
39
,
46
,
50
,
53
,
56
,
60
,
85
,
107
,
228
,
270
,
271
,
285
💬
9. TNF
×
Disease ID
Name
15
Inclusion body myositis
28
Systemic amyloidosis
35
Pemphigus
38
Stevens-Johnson syndrome
39
Toxic epidermal necrolysis
46
Malignant rheumatoid arthritis
50
Dermatomyositis
53
Sjogren syndrome
56
Behcet disease
60
Aplastic anemia
85
Idiopathic interstitial pneumonia
107
Juvenile idiopathic arthritis
228
Bronchiolitis obliterans
270
Chronic recurrent multifocal osteomyelitis
271
Ankylosing spondylitis
285
Fanconi anemia
10
TNF
💬
10. TNF
×
Name
Full Name
TNF
tumor necrosis factor
[67]
Antifolate resistance
Antifolate resistance
,
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Viral protein interaction with cytokine and cytokine receptor
,
NF-kappa B signaling pathway
,
Sphingolipid signaling pathway
,
mTOR signaling pathway
,
Apoptosis
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Antigen processing and presentation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
Hematopoietic cell lineage
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Adipocytokine signaling pathway
,
Type II diabetes mellitus
,
Insulin resistance
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Alcoholic liver disease
,
Type I diabetes mellitus
,
Alzheimer disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Legionellosis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis C
,
Hepatitis B
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Herpes simplex virus 1 infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Asthma
,
Inflammatory bowel disease
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
,
Allograft rejection
,
Graft-versus-host disease
,
Hypertrophic cardiomyopathy
,
Dilated cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[67]
Antifolate resistance
,
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Viral pr
...
Thalidomide
Thalidomide
💬
10. TNF
×
Name
Other Names
Thalidomide
Thalidomide (JAN/USP/INN)
Thalomid (TN)
Thaled (TN)
Thalidomide
[20]
2
2
,
16
,
20
,
28
,
49
,
51
,
53
,
56
,
65
,
84
,
85
,
94
,
96
,
97
,
227
,
271
,
280
,
298
,
300
,
331
💬
10. TNF
×
Disease ID
Name
2
Amyotrophic lateral sclerosis
16
Crow-Fukase syndrome
20
Adrenoleukodystrophy
28
Systemic amyloidosis
49
Systemic lupus erythematosus
51
Scleroderma
53
Sjogren syndrome
56
Behcet disease
65
Primary immunodeficiency
84
Sarcoidosis
85
Idiopathic interstitial pneumonia
94
Primary sclerosing cholangitis
96
Crohn disease
97
Ulcerative colitis
227
Osler disease
271
Ankylosing spondylitis
280
Huge arteriovenous malformation with cervicofacial or limb lesion
298
Hereditary pancreatitis
300
IgG4-related disease
331
Idiopathic multicentric castleman disease