Target Gene/Pathway Pathway / Gene

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KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[32] Proteasome, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Necroptosis, TGF-b ...

Fontolizumab 💬

[1] 46 💬

2

[32] Proteasome, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Necroptosis, TGF-b ...

Emapalumab 💬

[3] 49, 65, 107 💬

3

[21] MAPK signaling pathway, Cytokine-cytokine receptor interaction, Necroptosis, Cellular senescenc ...

Pirfenidone 💬

[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica
34	Neurofibromatosis
46	Malignant rheumatoid arthritis
50	Dermatomyositis
51	Scleroderma
58	Hypertrophic cardiomyopathy
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
164	Oculocutaneous albinism
222	Primary nephrotic syndrome
228	Bronchiolitis obliterans

4

[21] MAPK signaling pathway, Cytokine-cytokine receptor interaction, Necroptosis, Cellular senescenc ...

Rilonacept 💬

[4] 51, 106, 107, 266 💬

5

[21] MAPK signaling pathway, Cytokine-cytokine receptor interaction, Necroptosis, Cellular senescenc ...

Bermekimab 💬

[1] 51 💬

6

[44] Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa ...

Pirfenidone 💬

[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica
34	Neurofibromatosis
46	Malignant rheumatoid arthritis
50	Dermatomyositis
51	Scleroderma
58	Hypertrophic cardiomyopathy
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
164	Oculocutaneous albinism
222	Primary nephrotic syndrome
228	Bronchiolitis obliterans

7

[44] Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa ...

Rilonacept 💬

[4] 51, 106, 107, 266 💬

8

[44] Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa ...

Canakinumab 💬

[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬

Disease ID	Name
46	Malignant rheumatoid arthritis
56	Behcet disease
84	Sarcoidosis
106	Cryopyrin-associated periodic syndrome
107	Juvenile idiopathic arthritis
108	TNF receptor-associated periodic syndrome
113	Muscular dystrophy
266	Familial mediterranean fever
267	Hyper-IgD syndrome
269	Pyogenic arthritis

9

[44] Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa ...

Gevokizumab 💬

[4] 41, 50, 56, 269 💬

10

[51] EGFR tyrosine kinase inhibitor resistance, Antifolate resistance, Cytokine-cytokine receptor in ...

Pirfenidone 💬

[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica
34	Neurofibromatosis
46	Malignant rheumatoid arthritis
50	Dermatomyositis
51	Scleroderma
58	Hypertrophic cardiomyopathy
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
164	Oculocutaneous albinism
222	Primary nephrotic syndrome
228	Bronchiolitis obliterans

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