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KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
Disease ID
1
ADH1A
💬
1. ADH1A
×
Name
Full Name
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
[9]
Glycolysis / Gluconeogenesis
Glycolysis / Gluconeogenesis
,
Fatty acid degradation
,
Tyrosine metabolism
,
Pyruvate metabolism
,
Retinol metabolism
,
Metabolism of xenobiotics by cytochrome P450
,
Drug metabolism - cytochrome P450
,
Metabolic pathways
,
Alcoholic liver disease
[9]
Glycolysis / Gluconeogenesis
,
Fatty acid degradation
,
Tyrosine metabolism
,
Pyruvate metabolism
, ...
Fomepizole
Fomepizole
💬
1. ADH1A
×
Name
Other Names
Fomepizole
Fomepizole (JAN/USAN/INN)
Antizol (TN)
Fomepizole
[1]
301
301
💬
1. ADH1A
×
Disease ID
Name
301
Macular dystrophy
2
ADH1B
💬
2. ADH1B
×
Name
Full Name
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
[9]
Glycolysis / Gluconeogenesis
Glycolysis / Gluconeogenesis
,
Fatty acid degradation
,
Tyrosine metabolism
,
Pyruvate metabolism
,
Retinol metabolism
,
Metabolism of xenobiotics by cytochrome P450
,
Drug metabolism - cytochrome P450
,
Metabolic pathways
,
Alcoholic liver disease
[9]
Glycolysis / Gluconeogenesis
,
Fatty acid degradation
,
Tyrosine metabolism
,
Pyruvate metabolism
, ...
Fomepizole
Fomepizole
💬
2. ADH1B
×
Name
Other Names
Fomepizole
Fomepizole (JAN/USAN/INN)
Antizol (TN)
Fomepizole
[1]
301
301
💬
2. ADH1B
×
Disease ID
Name
301
Macular dystrophy
3
ADH1C
💬
3. ADH1C
×
Name
Full Name
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
[9]
Glycolysis / Gluconeogenesis
Glycolysis / Gluconeogenesis
,
Fatty acid degradation
,
Tyrosine metabolism
,
Pyruvate metabolism
,
Retinol metabolism
,
Metabolism of xenobiotics by cytochrome P450
,
Drug metabolism - cytochrome P450
,
Metabolic pathways
,
Alcoholic liver disease
[9]
Glycolysis / Gluconeogenesis
,
Fatty acid degradation
,
Tyrosine metabolism
,
Pyruvate metabolism
, ...
Fomepizole
Fomepizole
💬
3. ADH1C
×
Name
Other Names
Fomepizole
Fomepizole (JAN/USAN/INN)
Antizol (TN)
Fomepizole
[1]
301
301
💬
3. ADH1C
×
Disease ID
Name
301
Macular dystrophy
4
IFNGR1
💬
4. IFNGR1
×
Name
Full Name
IFNGR1
interferon gamma receptor 1
[18]
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Influenza A
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
[18]
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
Osteoclast differ
...
Interferon gamma-1b
Interferon gamma-1b
💬
4. IFNGR1
×
Name
Other Names
Interferon gamma-1b
Interferon gamma-1b (USAN/INN)
Actimmune (TN)
Interferon gamma-1b
[7]
18
18
,
65
,
85
,
228
,
299
,
301
,
326
💬
4. IFNGR1
×
Disease ID
Name
18
Spinocerebellar degeneration
65
Primary immunodeficiency
85
Idiopathic interstitial pneumonia
228
Bronchiolitis obliterans
299
Cystic fibrosis
301
Macular dystrophy
326
Osteopetrosis
5
IFNGR2
💬
5. IFNGR2
×
Name
Full Name
IFNGR2
interferon gamma receptor 2
[17]
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Influenza A
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
[17]
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
Osteoclast differ
...
Interferon gamma-1b
Interferon gamma-1b
💬
5. IFNGR2
×
Name
Other Names
Interferon gamma-1b
Interferon gamma-1b (USAN/INN)
Actimmune (TN)
Interferon gamma-1b
[7]
18
18
,
65
,
85
,
228
,
299
,
301
,
326
💬
5. IFNGR2
×
Disease ID
Name
18
Spinocerebellar degeneration
65
Primary immunodeficiency
85
Idiopathic interstitial pneumonia
228
Bronchiolitis obliterans
299
Cystic fibrosis
301
Macular dystrophy
326
Osteopetrosis
6
PRKAA1
💬
6. PRKAA1
×
Name
Full Name
PRKAA1
protein kinase AMP-activated catalytic subunit alpha 1
[20]
FoxO signaling pathway
FoxO signaling pathway
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
AMPK signaling pathway
,
Longevity regulating pathway
,
Longevity regulating pathway - multiple species
,
Apelin signaling pathway
,
Tight junction
,
Circadian rhythm
,
Thermogenesis
,
Insulin signaling pathway
,
Adipocytokine signaling pathway
,
Oxytocin signaling pathway
,
Glucagon signaling pathway
,
Insulin resistance
,
Non-alcoholic fatty liver disease
,
Alcoholic liver disease
,
Hypertrophic cardiomyopathy
,
Fluid shear stress and atherosclerosis
[20]
FoxO signaling pathway
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
, ...
Metformin
Metformin
💬
6. PRKAA1
×
Name
Other Names
Metformin
Metformin (USAN/INN)
Metformin
[25]
2
2
,
6
,
8
,
13
,
46
,
49
,
60
,
65
,
67
,
75
,
77
,
81
,
86
,
97
,
113
,
127
,
158
,
206
,
218
,
225
,
233
,
265
,
285
,
299
,
301
💬
[25]
2
,
6
,
8
,
13
,
46
,
49
,
60
,
65
,
67
,
75
,
77
,
81
,
86
,
97
,
113
,
127
,
158
,
206
,
218
,
225
,
233
,
265
,
28
...
6. PRKAA1
×
Disease ID
Name
2
Amyotrophic lateral sclerosis
6
Parkinson disease
8
Huntington disease
13
Multiple sclerosis/Neuromyelitis optica
46
Malignant rheumatoid arthritis
49
Systemic lupus erythematosus
60
Aplastic anemia
65
Primary immunodeficiency
67
Polycystic kidney disease
75
Cushing disease
77
Growth hormone secreting pituitary adenoma
81
Congenital adrenal hyperplasia
86
Pulmonary arterial hypertension
97
Ulcerative colitis
113
Muscular dystrophy
127
Frontotemporal lobar degeneration
158
Tuberous sclerosis
206
Fragile X syndrome
218
Alport syndrome
225
Congenital nephrogenic diabetes insipidus
233
Wolfram syndrome
265
Lipodystrophy
285
Fanconi anemia
299
Cystic fibrosis
301
Macular dystrophy
7
PRKAA2
💬
7. PRKAA2
×
Name
Full Name
PRKAA2
protein kinase AMP-activated catalytic subunit alpha 2
[20]
FoxO signaling pathway
FoxO signaling pathway
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
AMPK signaling pathway
,
Longevity regulating pathway
,
Longevity regulating pathway - multiple species
,
Apelin signaling pathway
,
Tight junction
,
Circadian rhythm
,
Thermogenesis
,
Insulin signaling pathway
,
Adipocytokine signaling pathway
,
Oxytocin signaling pathway
,
Glucagon signaling pathway
,
Insulin resistance
,
Non-alcoholic fatty liver disease
,
Alcoholic liver disease
,
Hypertrophic cardiomyopathy
,
Fluid shear stress and atherosclerosis
[20]
FoxO signaling pathway
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
, ...
Metformin
Metformin
💬
7. PRKAA2
×
Name
Other Names
Metformin
Metformin (USAN/INN)
Metformin
[25]
2
2
,
6
,
8
,
13
,
46
,
49
,
60
,
65
,
67
,
75
,
77
,
81
,
86
,
97
,
113
,
127
,
158
,
206
,
218
,
225
,
233
,
265
,
285
,
299
,
301
💬
[25]
2
,
6
,
8
,
13
,
46
,
49
,
60
,
65
,
67
,
75
,
77
,
81
,
86
,
97
,
113
,
127
,
158
,
206
,
218
,
225
,
233
,
265
,
28
...
7. PRKAA2
×
Disease ID
Name
2
Amyotrophic lateral sclerosis
6
Parkinson disease
8
Huntington disease
13
Multiple sclerosis/Neuromyelitis optica
46
Malignant rheumatoid arthritis
49
Systemic lupus erythematosus
60
Aplastic anemia
65
Primary immunodeficiency
67
Polycystic kidney disease
75
Cushing disease
77
Growth hormone secreting pituitary adenoma
81
Congenital adrenal hyperplasia
86
Pulmonary arterial hypertension
97
Ulcerative colitis
113
Muscular dystrophy
127
Frontotemporal lobar degeneration
158
Tuberous sclerosis
206
Fragile X syndrome
218
Alport syndrome
225
Congenital nephrogenic diabetes insipidus
233
Wolfram syndrome
265
Lipodystrophy
285
Fanconi anemia
299
Cystic fibrosis
301
Macular dystrophy
8
VEGFA
💬
8. VEGFA
×
Name
Full Name
VEGFA
vascular endothelial growth factor A
[24]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
HIF-1 signaling pathway
,
PI3K-Akt signaling pathway
,
VEGF signaling pathway
,
Focal adhesion
,
Relaxin signaling pathway
,
AGE-RAGE signaling pathway in diabetic complications
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Chemical carcinogenesis - reactive oxygen species
,
Renal cell carcinoma
,
Pancreatic cancer
,
Bladder cancer
,
Rheumatoid arthritis
,
Fluid shear stress and atherosclerosis
[24]
EGFR tyrosine kinase inhibitor resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1
...
Ranibizumab
Ranibizumab
💬
8. VEGFA
×
Name
Other Names
Ranibizumab
Ranibizumab (USAN/INN)
Ranibizumab (genetical recombination) (JAN)
Ranibizumab (genetical recombination) [Ranibizumab biosimilar 1] (JAN)
Ranibizumab-nuna
Lucentis (TN)
Byooviz (TN)
Susvimo (TN)
Ximluci (TN)
CIMERLI
Ranibizumab
[4]
34
34
,
166
,
227
,
301
💬
8. VEGFA
×
Disease ID
Name
34
Neurofibromatosis
166
Pseudoxanthoma elasticum
227
Osler disease
301
Macular dystrophy
9
PDE5A
💬
9. PDE5A
×
Name
Full Name
PDE5A
phosphodiesterase 5A
[3]
Purine metabolism
Purine metabolism
,
Metabolic pathways
,
cGMP-PKG signaling pathway
Sildenafil
Sildenafil
💬
9. PDE5A
×
Name
Other Names
Sildenafil
Sildenafil (INN)
Aphrodil (TN)
Sildenafil
[17]
6
6
,
46
,
50
,
51
,
85
,
86
,
90
,
113
,
210
,
211
,
212
,
225
,
226
,
278
,
294
,
299
,
301
💬
9. PDE5A
×
Disease ID
Name
6
Parkinson disease
46
Malignant rheumatoid arthritis
50
Dermatomyositis
51
Scleroderma
85
Idiopathic interstitial pneumonia
86
Pulmonary arterial hypertension
90
Retinitis pigmentosa
113
Muscular dystrophy
210
Single Ventricle
211
Hypoplastic left heart syndrome
212
Tricuspid atresia
225
Congenital nephrogenic diabetes insipidus
226
Interstitial cystitis with Hunners ulcer
278
Huge lymphatic malformation with cervicofacial lesion
294
Congenital diaphragmatic hernia
299
Cystic fibrosis
301
Macular dystrophy