Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 ADORA2A 1件: Vascular smooth muscle contraction D00045 Adenosine 3件: 13, 58, 65
2 ADORA2A 1件: Vascular smooth muscle contraction D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
3 ADORA2A 1件: Vascular smooth muscle contraction D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
4 ADORA2A 1件: Vascular smooth muscle contraction D02769 Adenosine phosphate 1件: 46
5 ADORA2A 1件: Vascular smooth muscle contraction D04641 Istradefylline 1件: 6
6 ADORA2A 1件: Vascular smooth muscle contraction D05711 Regadenoson 1件: 58
7 ADORA2A 1件: Vascular smooth muscle contraction D09717 Preladenant 1件: 6
8 ADORA2A 1件: Vascular smooth muscle contraction D10174 Tozadenant 1件: 6
9 ADORA2A 1件: Vascular smooth muscle contraction D12568 Regadenoson 1件: 58
10 ADORA2B 1件: Vascular smooth muscle contraction D00045 Adenosine 3件: 13, 58, 65
11 ADORA2B 1件: Vascular smooth muscle contraction D00227 Aminophylline 1件: 63
12 ADORA2B 1件: Vascular smooth muscle contraction D00371 Theophylline 2件: 236, 299
13 ADORA2B 1件: Vascular smooth muscle contraction D02769 Adenosine phosphate 1件: 46
14 ADORA2B 1件: Vascular smooth muscle contraction D06103 Theophylline 2件: 236, 299
15 ADRA1D 1件: Vascular smooth muscle contraction D00076 Norepinephrine 2件: 22, 296
16 ADRA1D 1件: Vascular smooth muscle contraction D00095 Epinephrine 3件: 46, 70, 96
17 ADRA1D 1件: Vascular smooth muscle contraction D00124 Ephedrine 1件: 11
18 ADRA1D 1件: Vascular smooth muscle contraction D00255 Carvedilol 4件: 57, 86, 113, 210
19 ADRA1D 1件: Vascular smooth muscle contraction D00454 Olanzapine 2件: 2, 8
20 ADRA1D 1件: Vascular smooth muscle contraction D01277 Droxidopa 5件: 5, 6, 17, 169, 170
21 ADRA1D 1件: Vascular smooth muscle contraction D02349 Dipivefrin 1件: 6
22 ADRA1D 1件: Vascular smooth muscle contraction D02910 Amiodarone 2件: 28, 127
23 ADRA1D 1件: Vascular smooth muscle contraction D07874 Doxazosin 2件: 57, 67
24 ADRA1D 1件: Vascular smooth muscle contraction D08207 Methylergometrine 1件: 280
25 ADRA1D 1件: Vascular smooth muscle contraction D08220 Midodrine 3件: 6, 17, 58
26 ADRA1D 1件: Vascular smooth muscle contraction D08365 Phenylephrine 1件: 22
27 ADRA1D 1件: Vascular smooth muscle contraction D08449 Pseudoephedrine 1件: 17
28 ADRA1D 1件: Vascular smooth muscle contraction D08560 Tamsulosin 1件: 13
29 ADRA1D 1件: Vascular smooth muscle contraction D08569 Terazosin 1件: 6
30 ADRA1B 1件: Vascular smooth muscle contraction D00076 Norepinephrine 2件: 22, 296
31 ADRA1B 1件: Vascular smooth muscle contraction D00095 Epinephrine 3件: 46, 70, 96
32 ADRA1B 1件: Vascular smooth muscle contraction D00124 Ephedrine 1件: 11
33 ADRA1B 1件: Vascular smooth muscle contraction D00255 Carvedilol 4件: 57, 86, 113, 210
34 ADRA1B 1件: Vascular smooth muscle contraction D00454 Olanzapine 2件: 2, 8
35 ADRA1B 1件: Vascular smooth muscle contraction D01277 Droxidopa 5件: 5, 6, 17, 169, 170
36 ADRA1B 1件: Vascular smooth muscle contraction D02349 Dipivefrin 1件: 6
37 ADRA1B 1件: Vascular smooth muscle contraction D02910 Amiodarone 2件: 28, 127
38 ADRA1B 1件: Vascular smooth muscle contraction D07874 Doxazosin 2件: 57, 67
39 ADRA1B 1件: Vascular smooth muscle contraction D08207 Methylergometrine 1件: 280
40 ADRA1B 1件: Vascular smooth muscle contraction D08220 Midodrine 3件: 6, 17, 58
41 ADRA1B 1件: Vascular smooth muscle contraction D08365 Phenylephrine 1件: 22
42 ADRA1B 1件: Vascular smooth muscle contraction D08449 Pseudoephedrine 1件: 17
43 ADRA1B 1件: Vascular smooth muscle contraction D08560 Tamsulosin 1件: 13
44 ADRA1B 1件: Vascular smooth muscle contraction D08569 Terazosin 1件: 6
45 ADRA1A 1件: Vascular smooth muscle contraction D00076 Norepinephrine 2件: 22, 296
46 ADRA1A 1件: Vascular smooth muscle contraction D00095 Epinephrine 3件: 46, 70, 96
47 ADRA1A 1件: Vascular smooth muscle contraction D00124 Ephedrine 1件: 11
48 ADRA1A 1件: Vascular smooth muscle contraction D00255 Carvedilol 4件: 57, 86, 113, 210
49 ADRA1A 1件: Vascular smooth muscle contraction D00454 Olanzapine 2件: 2, 8
50 ADRA1A 1件: Vascular smooth muscle contraction D01277 Droxidopa 5件: 5, 6, 17, 169, 170
51 ADRA1A 1件: Vascular smooth muscle contraction D01965 Silodosin 2件: 6, 13
52 ADRA1A 1件: Vascular smooth muscle contraction D02349 Dipivefrin 1件: 6
53 ADRA1A 1件: Vascular smooth muscle contraction D02910 Amiodarone 2件: 28, 127
54 ADRA1A 1件: Vascular smooth muscle contraction D07124 Alfuzosin 1件: 13
55 ADRA1A 1件: Vascular smooth muscle contraction D07874 Doxazosin 2件: 57, 67
56 ADRA1A 1件: Vascular smooth muscle contraction D08207 Methylergometrine 1件: 280
57 ADRA1A 1件: Vascular smooth muscle contraction D08220 Midodrine 3件: 6, 17, 58
58 ADRA1A 1件: Vascular smooth muscle contraction D08365 Phenylephrine 1件: 22
59 ADRA1A 1件: Vascular smooth muscle contraction D08449 Pseudoephedrine 1件: 17
60 ADRA1A 1件: Vascular smooth muscle contraction D08560 Tamsulosin 1件: 13
61 ADRA1A 1件: Vascular smooth muscle contraction D08569 Terazosin 1件: 6
62 AGTR1 1件: Vascular smooth muscle contraction D00150 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224
63 AGTR1 1件: Vascular smooth muscle contraction D00400 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224
64 AGTR1 1件: Vascular smooth muscle contraction D00522 Candesartan 2件: 58, 67
65 AGTR1 1件: Vascular smooth muscle contraction D00523 Irbesartan 4件: 66, 167, 168, 222
66 AGTR1 1件: Vascular smooth muscle contraction D00626 Candesartan cilexetil 1件: 67
67 AGTR1 1件: Vascular smooth muscle contraction D00627 Telmisartan 2件: 66, 67
68 AGTR1 1件: Vascular smooth muscle contraction D02014 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224
69 AGTR1 1件: Vascular smooth muscle contraction D08146 Losartan 17件: 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299
70 AGTR1 1件: Vascular smooth muscle contraction D11776 Sparsentan 3件: 66, 218, 222
71 EDNRA 1件: Vascular smooth muscle contraction D01227 Bosentan 10件: 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
72 EDNRA 1件: Vascular smooth muscle contraction D07077 Ambrisentan 7件: 51, 84, 85, 86, 88, 210, 211
73 EDNRA 1件: Vascular smooth muscle contraction D07171 Sitaxentan 1件: 86
74 EDNRA 1件: Vascular smooth muscle contraction D07538 Bosentan 10件: 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
75 EDNRA 1件: Vascular smooth muscle contraction D07741 Zibotentan 1件: 51
76 EDNRA 1件: Vascular smooth muscle contraction D10135 Macitentan 5件: 51, 85, 86, 88, 210
77 EDNRA 1件: Vascular smooth muscle contraction D11776 Sparsentan 3件: 66, 218, 222
78 GUCY1A2 1件: Vascular smooth muscle contraction D00517 Amyl Nitrite 1件: 58
79 GUCY1A2 1件: Vascular smooth muscle contraction D09572 Riociguat 6件: 51, 84, 86, 88, 225, 299
80 GUCY1A1 1件: Vascular smooth muscle contraction D00517 Amyl Nitrite 1件: 58
81 GUCY1A1 1件: Vascular smooth muscle contraction D09572 Riociguat 6件: 51, 84, 86, 88, 225, 299
82 GUCY1B1 1件: Vascular smooth muscle contraction D00517 Amyl Nitrite 1件: 58
83 GUCY1B1 1件: Vascular smooth muscle contraction D09572 Riociguat 6件: 51, 84, 86, 88, 225, 299
84 NPR1 1件: Vascular smooth muscle contraction D04051 Erythrityl tetranitrate 1件: 46
85 NPR1 1件: Vascular smooth muscle contraction D05147 Nesiritide 2件: 46, 58
86 NPR2 1件: Vascular smooth muscle contraction D04051 Erythrityl tetranitrate 1件: 46
87 NPR2 1件: Vascular smooth muscle contraction D11190 Vosoritide 1件: 276
88 AVPR1A 1件: Vascular smooth muscle contraction D00101 Vasopressin 1件: 210
89 AVPR1A 1件: Vascular smooth muscle contraction D06672 Terlipressin 1件: 299
90 AVPR1A 1件: Vascular smooth muscle contraction D07748 Conivaptan 1件: 86
91 AVPR1B 1件: Vascular smooth muscle contraction D00101 Vasopressin 1件: 210
92 AVPR1B 1件: Vascular smooth muscle contraction D06672 Terlipressin 1件: 299
93 PRKCB 3件: Vascular smooth muscle contraction, Wnt signaling pathway, VEGF signaling pathway D11935 Enzastaurin 1件: 168
94 PRKCD 1件: Vascular smooth muscle contraction D09671 Sotrastaurin 1件: 97
95 PRKCE 1件: Vascular smooth muscle contraction D09671 Sotrastaurin 1件: 97
96 PRKCH 1件: Vascular smooth muscle contraction D09671 Sotrastaurin 1件: 97
97 PRKCQ 1件: Vascular smooth muscle contraction D09671 Sotrastaurin 1件: 97
98 MAP2K1 3件: Vascular smooth muscle contraction, VEGF signaling pathway, Yersinia infection D09666 Selumetinib 1件: 34
99 MAP2K1 3件: Vascular smooth muscle contraction, VEGF signaling pathway, Yersinia infection D10175 Trametinib 4件: 2, 34, 279, 280
100 MAP2K1 3件: Vascular smooth muscle contraction, VEGF signaling pathway, Yersinia infection D10405 Cobimetinib 1件: 280
101 MAP2K1 3件: Vascular smooth muscle contraction, VEGF signaling pathway, Yersinia infection D10604 Binimetinib 1件: 34
102 MAP2K1 3件: Vascular smooth muscle contraction, VEGF signaling pathway, Yersinia infection D11675 Mirdametinib 1件: 34
103 MAP2K2 3件: Vascular smooth muscle contraction, VEGF signaling pathway, Yersinia infection D09666 Selumetinib 1件: 34
104 MAP2K2 3件: Vascular smooth muscle contraction, VEGF signaling pathway, Yersinia infection D10175 Trametinib 4件: 2, 34, 279, 280
105 MAP2K2 3件: Vascular smooth muscle contraction, VEGF signaling pathway, Yersinia infection D10405 Cobimetinib 1件: 280
106 MAP2K2 3件: Vascular smooth muscle contraction, VEGF signaling pathway, Yersinia infection D10604 Binimetinib 1件: 34
107 MAP2K2 3件: Vascular smooth muscle contraction, VEGF signaling pathway, Yersinia infection D11675 Mirdametinib 1件: 34
108 PTGIR 1件: Vascular smooth muscle contraction D00106 Epoprostenol 1件: 86
109 PTGIR 1件: Vascular smooth muscle contraction D01385 Ibudilast 2件: 2, 13
110 PTGIR 1件: Vascular smooth muscle contraction D02720 Beraprost 1件: 86
111 PTGIR 1件: Vascular smooth muscle contraction D02721 Iloprost 4件: 51, 84, 85, 86
112 PTGIR 1件: Vascular smooth muscle contraction D06213 Treprostinil 6件: 51, 84, 85, 86, 88, 210
113 PTGIR 1件: Vascular smooth muscle contraction D09994 Selexipag 5件: 51, 70, 84, 86, 88
114 PTGIR 1件: Vascular smooth muscle contraction D10725 Ralinepag 1件: 86
115 RAF1 2件: Vascular smooth muscle contraction, VEGF signaling pathway D08524 Sorafenib 2件: 34, 86
116 ROCK1 2件: Vascular smooth muscle contraction, Yersinia infection D07941 Fasudil 4件: 2, 5, 7, 51
117 BRAF 1件: Vascular smooth muscle contraction D08524 Sorafenib 2件: 34, 86
118 BRAF 1件: Vascular smooth muscle contraction D10064 Dabrafenib 1件: 34
119 CACNA1C 1件: Vascular smooth muscle contraction D00349 Isradipine 1件: 6
120 CACNA1C 1件: Vascular smooth muscle contraction D00437 Nifedipine 2件: 50, 81
121 CACNA1C 1件: Vascular smooth muscle contraction D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
122 CACNA1C 1件: Vascular smooth muscle contraction D01173 Cilnidipine 1件: 67
123 CACNA1C 1件: Vascular smooth muscle contraction D01908 Nilvadipine 1件: 90
124 CACNA1C 1件: Vascular smooth muscle contraction D02356 Verapamil 4件: 58, 96, 140, 167
125 CACNA1C 1件: Vascular smooth muscle contraction D07450 Amlodipine 4件: 13, 51, 67, 298
126 CACNA1C 1件: Vascular smooth muscle contraction D07845 Diltiazem 3件: 51, 58, 86
127 CACNA1C 1件: Vascular smooth muscle contraction D08270 Nicardipine 2件: 70, 86
128 CACNA1C 1件: Vascular smooth muscle contraction D08340 Perhexiline 2件: 58, 272
129 CACNA1C 1件: Vascular smooth muscle contraction D08441 Propiverine 1件: 226
130 CACNA1D 1件: Vascular smooth muscle contraction D00349 Isradipine 1件: 6
131 CACNA1D 1件: Vascular smooth muscle contraction D00437 Nifedipine 2件: 50, 81
132 CACNA1D 1件: Vascular smooth muscle contraction D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
133 CACNA1D 1件: Vascular smooth muscle contraction D01173 Cilnidipine 1件: 67
134 CACNA1D 1件: Vascular smooth muscle contraction D01908 Nilvadipine 1件: 90
135 CACNA1D 1件: Vascular smooth muscle contraction D02356 Verapamil 4件: 58, 96, 140, 167
136 CACNA1D 1件: Vascular smooth muscle contraction D07450 Amlodipine 4件: 13, 51, 67, 298
137 CACNA1D 1件: Vascular smooth muscle contraction D07845 Diltiazem 3件: 51, 58, 86
138 CACNA1D 1件: Vascular smooth muscle contraction D08270 Nicardipine 2件: 70, 86
139 CACNA1D 1件: Vascular smooth muscle contraction D08340 Perhexiline 2件: 58, 272
140 CACNA1D 1件: Vascular smooth muscle contraction D08441 Propiverine 1件: 226
141 CACNA1F 1件: Vascular smooth muscle contraction D00349 Isradipine 1件: 6
142 CACNA1F 1件: Vascular smooth muscle contraction D00437 Nifedipine 2件: 50, 81
143 CACNA1F 1件: Vascular smooth muscle contraction D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
144 CACNA1F 1件: Vascular smooth muscle contraction D01173 Cilnidipine 1件: 67
145 CACNA1F 1件: Vascular smooth muscle contraction D01908 Nilvadipine 1件: 90
146 CACNA1F 1件: Vascular smooth muscle contraction D02356 Verapamil 4件: 58, 96, 140, 167
147 CACNA1F 1件: Vascular smooth muscle contraction D07450 Amlodipine 4件: 13, 51, 67, 298
148 CACNA1F 1件: Vascular smooth muscle contraction D07845 Diltiazem 3件: 51, 58, 86
149 CACNA1F 1件: Vascular smooth muscle contraction D08270 Nicardipine 2件: 70, 86
150 CACNA1F 1件: Vascular smooth muscle contraction D08340 Perhexiline 2件: 58, 272
151 CACNA1F 1件: Vascular smooth muscle contraction D08441 Propiverine 1件: 226
152 CACNA1S 1件: Vascular smooth muscle contraction D00349 Isradipine 1件: 6
153 CACNA1S 1件: Vascular smooth muscle contraction D00437 Nifedipine 2件: 50, 81
154 CACNA1S 1件: Vascular smooth muscle contraction D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
155 CACNA1S 1件: Vascular smooth muscle contraction D01173 Cilnidipine 1件: 67
156 CACNA1S 1件: Vascular smooth muscle contraction D01908 Nilvadipine 1件: 90
157 CACNA1S 1件: Vascular smooth muscle contraction D02356 Verapamil 4件: 58, 96, 140, 167
158 CACNA1S 1件: Vascular smooth muscle contraction D07450 Amlodipine 4件: 13, 51, 67, 298
159 CACNA1S 1件: Vascular smooth muscle contraction D07845 Diltiazem 3件: 51, 58, 86
160 CACNA1S 1件: Vascular smooth muscle contraction D08270 Nicardipine 2件: 70, 86
161 CACNA1S 1件: Vascular smooth muscle contraction D08340 Perhexiline 2件: 58, 272
162 CACNA1S 1件: Vascular smooth muscle contraction D08441 Propiverine 1件: 226
163 CALCA 1件: Vascular smooth muscle contraction D11055 Fremanezumab 2件: 124, 226
164 ROCK2 3件: Vascular smooth muscle contraction, Wnt signaling pathway, Yersinia infection D07941 Fasudil 4件: 2, 5, 7, 51
165 ROCK2 3件: Vascular smooth muscle contraction, Wnt signaling pathway, Yersinia infection D11815 Belumosudil 2件: 51, 85