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KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
Disease ID
1
IL17F
💬
1. IL17F
×
Name
Full Name
IL17F
interleukin 17F
[4]
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
IL-17 signaling pathway
,
Th17 cell differentiation
,
Inflammatory bowel disease
[4]
Cytokine-cytokine receptor interaction
,
IL-17 signaling pathway
,
Th17 cell differentiation
,
Infl
...
Bimekizumab
Bimekizumab
💬
1. IL17F
×
Name
Other Names
Bimekizumab
Bimekizumab (USAN/INN)
Bimekizumab (genetical recombination) (JAN)
Bimzelx (TN)
Bimekizumab
[3]
46
46
,
97
,
271
💬
1. IL17F
×
Disease ID
Name
46
Malignant rheumatoid arthritis
97
Ulcerative colitis
271
Ankylosing spondylitis
2
IFNG
💬
2. IFNG
×
Name
Full Name
IFNG
interferon gamma
[32]
Proteasome
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Antigen processing and presentation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Type I diabetes mellitus
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis C
,
Influenza A
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
,
Allograft rejection
,
Graft-versus-host disease
,
Fluid shear stress and atherosclerosis
[32]
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-b
...
Fontolizumab
Fontolizumab
💬
2. IFNG
×
Name
Other Names
Fontolizumab
Fontolizumab (USAN/INN)
Fontolizumab
[1]
46
46
💬
2. IFNG
×
Disease ID
Name
46
Malignant rheumatoid arthritis
3
IFNG
💬
3. IFNG
×
Name
Full Name
IFNG
interferon gamma
[32]
Proteasome
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Antigen processing and presentation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Type I diabetes mellitus
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis C
,
Influenza A
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
,
Allograft rejection
,
Graft-versus-host disease
,
Fluid shear stress and atherosclerosis
[32]
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-b
...
Emapalumab
Emapalumab
💬
3. IFNG
×
Name
Other Names
Emapalumab
Emapalumab (USAN/INN)
Emapalumab (genetical recombination) (JAN)
Emapalumab-lzsg
Gamifant (TN)
Emapalumab
[3]
49
49
,
65
,
107
💬
3. IFNG
×
Disease ID
Name
49
Systemic lupus erythematosus
65
Primary immunodeficiency
107
Juvenile idiopathic arthritis
4
IFNGR1
💬
4. IFNGR1
×
Name
Full Name
IFNGR1
interferon gamma receptor 1
[18]
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Influenza A
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
[18]
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
Osteoclast differ
...
Interferon gamma-1b
Interferon gamma-1b
💬
4. IFNGR1
×
Name
Other Names
Interferon gamma-1b
Interferon gamma-1b (USAN/INN)
Actimmune (TN)
Interferon gamma-1b
[7]
18
18
,
65
,
85
,
228
,
299
,
301
,
326
💬
4. IFNGR1
×
Disease ID
Name
18
Spinocerebellar degeneration
65
Primary immunodeficiency
85
Idiopathic interstitial pneumonia
228
Bronchiolitis obliterans
299
Cystic fibrosis
301
Macular dystrophy
326
Osteopetrosis
5
IFNGR2
💬
5. IFNGR2
×
Name
Full Name
IFNGR2
interferon gamma receptor 2
[17]
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Influenza A
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
[17]
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
Osteoclast differ
...
Interferon gamma-1b
Interferon gamma-1b
💬
5. IFNGR2
×
Name
Other Names
Interferon gamma-1b
Interferon gamma-1b (USAN/INN)
Actimmune (TN)
Interferon gamma-1b
[7]
18
18
,
65
,
85
,
228
,
299
,
301
,
326
💬
5. IFNGR2
×
Disease ID
Name
18
Spinocerebellar degeneration
65
Primary immunodeficiency
85
Idiopathic interstitial pneumonia
228
Bronchiolitis obliterans
299
Cystic fibrosis
301
Macular dystrophy
326
Osteopetrosis
6
IL1A
💬
6. IL1A
×
Name
Full Name
IL1A
interleukin 1 alpha
[21]
MAPK signaling pathway
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Necroptosis
,
Cellular senescence
,
Osteoclast differentiation
,
Hematopoietic cell lineage
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Type I diabetes mellitus
,
Alzheimer disease
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Pertussis
,
Leishmaniasis
,
Tuberculosis
,
Measles
,
Influenza A
,
Inflammatory bowel disease
,
Rheumatoid arthritis
,
Graft-versus-host disease
,
Fluid shear stress and atherosclerosis
[21]
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Necroptosis
,
Cellular senescenc
...
Pirfenidone
Pirfenidone
💬
6. IL1A
×
Name
Other Names
Pirfenidone
Pirfenidone (JAN/USAN/INN)
Esbriet (TN)
Pirfenidone
[11]
13
13
,
34
,
46
,
50
,
51
,
58
,
84
,
85
,
164
,
222
,
228
💬
6. IL1A
×
Disease ID
Name
13
Multiple sclerosis/Neuromyelitis optica
34
Neurofibromatosis
46
Malignant rheumatoid arthritis
50
Dermatomyositis
51
Scleroderma
58
Hypertrophic cardiomyopathy
84
Sarcoidosis
85
Idiopathic interstitial pneumonia
164
Oculocutaneous albinism
222
Primary nephrotic syndrome
228
Bronchiolitis obliterans
7
IL1A
💬
7. IL1A
×
Name
Full Name
IL1A
interleukin 1 alpha
[21]
MAPK signaling pathway
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Necroptosis
,
Cellular senescence
,
Osteoclast differentiation
,
Hematopoietic cell lineage
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Type I diabetes mellitus
,
Alzheimer disease
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Pertussis
,
Leishmaniasis
,
Tuberculosis
,
Measles
,
Influenza A
,
Inflammatory bowel disease
,
Rheumatoid arthritis
,
Graft-versus-host disease
,
Fluid shear stress and atherosclerosis
[21]
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Necroptosis
,
Cellular senescenc
...
Rilonacept
Rilonacept
💬
7. IL1A
×
Name
Other Names
Rilonacept
Rilonacept (USAN/INN)
Arcalyst (TN)
Rilonacept
[4]
51
51
,
106
,
107
,
266
💬
7. IL1A
×
Disease ID
Name
51
Scleroderma
106
Cryopyrin-associated periodic syndrome
107
Juvenile idiopathic arthritis
266
Familial mediterranean fever
8
IL1A
💬
8. IL1A
×
Name
Full Name
IL1A
interleukin 1 alpha
[21]
MAPK signaling pathway
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Necroptosis
,
Cellular senescence
,
Osteoclast differentiation
,
Hematopoietic cell lineage
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Type I diabetes mellitus
,
Alzheimer disease
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Pertussis
,
Leishmaniasis
,
Tuberculosis
,
Measles
,
Influenza A
,
Inflammatory bowel disease
,
Rheumatoid arthritis
,
Graft-versus-host disease
,
Fluid shear stress and atherosclerosis
[21]
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Necroptosis
,
Cellular senescenc
...
Bermekimab
Bermekimab
💬
8. IL1A
×
Name
Other Names
Bermekimab
Bermekimab (USAN)
Bermekimab
[1]
51
51
💬
8. IL1A
×
Disease ID
Name
51
Scleroderma
9
IL1B
💬
9. IL1B
×
Name
Full Name
IL1B
interleukin 1 beta
[44]
Antifolate resistance
Antifolate resistance
,
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
NF-kappa B signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
Cytosolic DNA-sensing pathway
,
C-type lectin receptor signaling pathway
,
Hematopoietic cell lineage
,
IL-17 signaling pathway
,
Th17 cell differentiation
,
TNF signaling pathway
,
Inflammatory mediator regulation of TRP channels
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Alcoholic liver disease
,
Type I diabetes mellitus
,
Alzheimer disease
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Legionellosis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Amoebiasis
,
Tuberculosis
,
Measles
,
Human cytomegalovirus infection
,
Influenza A
,
Herpes simplex virus 1 infection
,
Coronavirus disease - COVID-19
,
Inflammatory bowel disease
,
Rheumatoid arthritis
,
Graft-versus-host disease
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[44]
Antifolate resistance
,
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
NF-kappa
...
Pirfenidone
Pirfenidone
💬
9. IL1B
×
Name
Other Names
Pirfenidone
Pirfenidone (JAN/USAN/INN)
Esbriet (TN)
Pirfenidone
[11]
13
13
,
34
,
46
,
50
,
51
,
58
,
84
,
85
,
164
,
222
,
228
💬
9. IL1B
×
Disease ID
Name
13
Multiple sclerosis/Neuromyelitis optica
34
Neurofibromatosis
46
Malignant rheumatoid arthritis
50
Dermatomyositis
51
Scleroderma
58
Hypertrophic cardiomyopathy
84
Sarcoidosis
85
Idiopathic interstitial pneumonia
164
Oculocutaneous albinism
222
Primary nephrotic syndrome
228
Bronchiolitis obliterans
10
IL1B
💬
10. IL1B
×
Name
Full Name
IL1B
interleukin 1 beta
[44]
Antifolate resistance
Antifolate resistance
,
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
NF-kappa B signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
Cytosolic DNA-sensing pathway
,
C-type lectin receptor signaling pathway
,
Hematopoietic cell lineage
,
IL-17 signaling pathway
,
Th17 cell differentiation
,
TNF signaling pathway
,
Inflammatory mediator regulation of TRP channels
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Alcoholic liver disease
,
Type I diabetes mellitus
,
Alzheimer disease
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Legionellosis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Amoebiasis
,
Tuberculosis
,
Measles
,
Human cytomegalovirus infection
,
Influenza A
,
Herpes simplex virus 1 infection
,
Coronavirus disease - COVID-19
,
Inflammatory bowel disease
,
Rheumatoid arthritis
,
Graft-versus-host disease
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[44]
Antifolate resistance
,
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
NF-kappa
...
Rilonacept
Rilonacept
💬
10. IL1B
×
Name
Other Names
Rilonacept
Rilonacept (USAN/INN)
Arcalyst (TN)
Rilonacept
[4]
51
51
,
106
,
107
,
266
💬
10. IL1B
×
Disease ID
Name
51
Scleroderma
106
Cryopyrin-associated periodic syndrome
107
Juvenile idiopathic arthritis
266
Familial mediterranean fever