Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 MAPK14 6件: VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
2 MAPK14 6件: VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
3 CSF2 2件: TNF signaling pathway, Transcriptional misregulation in cancer D11343 Otilimab 1件: 46
4 IL1B 5件: Toll-like receptor signaling pathway, TNF signaling pathway, Type I diabetes mellitus, Yersinia infection, Tuberculosis D01583 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
5 IL1B 5件: Toll-like receptor signaling pathway, TNF signaling pathway, Type I diabetes mellitus, Yersinia infection, Tuberculosis D06635 Rilonacept 4件: 51, 106, 107, 266
6 IL1B 5件: Toll-like receptor signaling pathway, TNF signaling pathway, Type I diabetes mellitus, Yersinia infection, Tuberculosis D09315 Canakinumab 10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269
7 IL1B 5件: Toll-like receptor signaling pathway, TNF signaling pathway, Type I diabetes mellitus, Yersinia infection, Tuberculosis D09911 Gevokizumab 4件: 41, 50, 56, 269
8 IL6 6件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, TNF signaling pathway, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer D01583 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
9 IL6 6件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, TNF signaling pathway, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer D08976 Pomalidomide 5件: 28, 51, 85, 227, 331
10 IL6 6件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, TNF signaling pathway, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer D09669 Siltuximab 2件: 28, 331
11 IL6 6件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, TNF signaling pathway, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer D10080 Sirukumab 2件: 41, 46
12 IL6 6件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, TNF signaling pathway, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer D12487 Olokizumab 2件: 46, 96
13 LTA 3件: Viral protein interaction with cytokine and cytokine receptor, TNF signaling pathway, Type I diabetes mellitus D00742 Etanercept 16件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285
14 LTA 3件: Viral protein interaction with cytokine and cytokine receptor, TNF signaling pathway, Type I diabetes mellitus D10187 Pateclizumab 1件: 46
15 MAP3K5 1件: TNF signaling pathway D10988 Selonsertib 1件: 86
16 NFKB1 7件: Toll-like receptor signaling pathway, TNF signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis D01146 Iguratimod 5件: 46, 51, 53, 271, 300
17 PIK3CA 6件: VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11011 Alpelisib 1件: 138
18 PIK3CA 6件: VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11158 Leniolisib 2件: 53, 65
19 PIK3CB 6件: VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11158 Leniolisib 2件: 53, 65
20 PIK3CD 6件: VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11158 Leniolisib 2件: 53, 65
21 PIK3CD 6件: VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11437 Parsaclisib 3件: 35, 53, 61
22 MAPK11 6件: VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
23 MAPK11 6件: VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
24 MAPK13 6件: VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
25 MAPK13 6件: VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
26 MAP2K1 5件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Yersinia infection D09666 Selumetinib 1件: 34
27 MAP2K1 5件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Yersinia infection D10175 Trametinib 4件: 2, 34, 279, 280
28 MAP2K1 5件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Yersinia infection D10405 Cobimetinib 1件: 280
29 MAP2K1 5件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Yersinia infection D10604 Binimetinib 1件: 34
30 MAP2K1 5件: Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Yersinia infection D11675 Mirdametinib 1件: 34
31 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D00109 Acetylsalicylic acid 14件: 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251
32 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D00118 Naproxen 4件: 13, 46, 107, 271
33 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D00120 Sulindac 1件: 206
34 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D00126 Ibuprofen 7件: 13, 46, 65, 107, 113, 271, 299
35 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D00130 Diflunisal 1件: 28
36 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D00132 Ketoprofen 1件: 46
37 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D00141 Indomethacin 3件: 225, 271, 298
38 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D00217 Acetaminophen 15件: 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337
39 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D00315 Etodolac 1件: 46
40 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D00330 Flurbiprofen 3件: 13, 21, 46
41 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D00428 Salsalate 1件: 5
42 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D00567 Celecoxib 10件: 2, 3, 34, 46, 70, 89, 107, 161, 171, 271
43 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D00568 Rofecoxib 1件: 46
44 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D00969 Meloxicam 4件: 46, 49, 271, 296
45 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D01049 Nimesulide 1件: 46
46 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D01183 Tolfenamic acid 1件: 5
47 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D01545 Aceclofenac 1件: 46
48 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D02709 Valdecoxib 1件: 46
49 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D03710 Etoricoxib 2件: 46, 271
50 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D03714 Lumiracoxib 1件: 46
51 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D03716 Parecoxib 2件: 46, 271
52 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D07816 Diclofenac 5件: 13, 34, 46, 78, 271
53 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D08104 Ketorolac 2件: 70, 226
54 PTGS2 2件: VEGF signaling pathway, TNF signaling pathway D08149 Loxoprofen 2件: 46, 271
55 RELA 7件: Toll-like receptor signaling pathway, TNF signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis D12181 Edasalonexent 1件: 113
56 MAPK12 6件: VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
57 MAPK12 6件: VEGF signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
58 CCL2 3件: Viral protein interaction with cytokine and cytokine receptor, TNF signaling pathway, Yersinia infection D01583 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
59 TNF 8件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D00742 Etanercept 16件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285
60 TNF 8件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D00754 Thalidomide 20件: 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331
61 TNF 8件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D01583 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
62 TNF 8件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D02597 Adalimumab 17件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271
63 TNF 8件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D02598 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271
64 TNF 8件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D03441 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271
65 TNF 8件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D04358 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271
66 TNF 8件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D04687 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331
67 TNF 8件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D05393 Pegsunercept 1件: 46
68 TNF 8件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D08976 Pomalidomide 5件: 28, 51, 85, 227, 331
69 TNF 8件: Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D09944 Ozoralizumab 1件: 46