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KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
Disease ID
1
ADRB2
💬
1. ADRB2
×
Name
Full Name
ADRB2
adrenoceptor beta 2
[9]
Calcium signaling pathway
Calcium signaling pathway
,
cGMP-PKG signaling pathway
,
cAMP signaling pathway
,
Neuroactive ligand-receptor interaction
,
Adrenergic signaling in cardiomyocytes
,
Regulation of lipolysis in adipocytes
,
Renin secretion
,
Salivary secretion
,
Chemical carcinogenesis - receptor activation
[9]
Calcium signaling pathway
,
cGMP-PKG signaling pathway
,
cAMP signaling pathway
,
Neuroactive ligan
...
Albuterol
Albuterol
💬
1. ADRB2
×
Name
Other Names
Albuterol
Albuterol (USP)
Salbutamol
Proventil (TN)
Salbutamol
[12]
3
3
,
11
,
12
,
13
,
49
,
85
,
86
,
89
,
111
,
113
,
256
,
299
💬
1. ADRB2
×
Disease ID
Name
3
Spinal muscular atrophy
11
Myasthenia gravis
12
Congenital myasthenic syndrome
13
Multiple sclerosis/Neuromyelitis optica
49
Systemic lupus erythematosus
85
Idiopathic interstitial pneumonia
86
Pulmonary arterial hypertension
89
Lymphangioleiomyomatosis
111
Congenital myopathy
113
Muscular dystrophy
256
Muscle glycogenosis
299
Cystic fibrosis
2
CYP19A1
💬
2. CYP19A1
×
Name
Full Name
CYP19A1
cytochrome P450 family 19 subfamily A member 1
[3]
Steroid hormone biosynthesis
Steroid hormone biosynthesis
,
Metabolic pathways
,
Ovarian steroidogenesis
Letrozole
Letrozole
💬
2. CYP19A1
×
Name
Other Names
Letrozole
Letrozole (JAN/USP/INN)
Femara (TN)
Letrozole
[2]
81
81
,
89
💬
2. CYP19A1
×
Disease ID
Name
81
Congenital adrenal hyperplasia
89
Lymphangioleiomyomatosis
3
FGFR1
💬
3. FGFR1
×
Name
Full Name
FGFR1
fibroblast growth factor receptor 1
[16]
MAPK signaling pathway
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
PI3K-Akt signaling pathway
,
Adherens junction
,
Signaling pathways regulating pluripotency of stem cells
,
Thermogenesis
,
Regulation of actin cytoskeleton
,
Parathyroid hormone synthesis, secretion and action
,
Pathways in cancer
,
Proteoglycans in cancer
,
Prostate cancer
,
Melanoma
,
Breast cancer
,
Central carbon metabolism in cancer
[16]
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathwa
...
Nintedanib
Nintedanib
💬
3. FGFR1
×
Name
Other Names
Nintedanib
Nintedanib (USAN/INN)
Ofev (TN)
Nintedanib
[5]
51
51
,
85
,
89
,
227
,
228
💬
3. FGFR1
×
Disease ID
Name
51
Scleroderma
85
Idiopathic interstitial pneumonia
89
Lymphangioleiomyomatosis
227
Osler disease
228
Bronchiolitis obliterans
4
FGFR3
💬
4. FGFR3
×
Name
Full Name
FGFR3
fibroblast growth factor receptor 3
[13]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
Endocytosis
,
PI3K-Akt signaling pathway
,
Signaling pathways regulating pluripotency of stem cells
,
Regulation of actin cytoskeleton
,
Pathways in cancer
,
MicroRNAs in cancer
,
Bladder cancer
,
Central carbon metabolism in cancer
[13]
EGFR tyrosine kinase inhibitor resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1
...
Nintedanib
Nintedanib
💬
4. FGFR3
×
Name
Other Names
Nintedanib
Nintedanib (USAN/INN)
Ofev (TN)
Nintedanib
[5]
51
51
,
85
,
89
,
227
,
228
💬
4. FGFR3
×
Disease ID
Name
51
Scleroderma
85
Idiopathic interstitial pneumonia
89
Lymphangioleiomyomatosis
227
Osler disease
228
Bronchiolitis obliterans
5
FGFR2
💬
5. FGFR2
×
Name
Full Name
FGFR2
fibroblast growth factor receptor 2
[13]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
Endocytosis
,
PI3K-Akt signaling pathway
,
Signaling pathways regulating pluripotency of stem cells
,
Regulation of actin cytoskeleton
,
Pathways in cancer
,
Prostate cancer
,
Gastric cancer
,
Central carbon metabolism in cancer
[13]
EGFR tyrosine kinase inhibitor resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1
...
Nintedanib
Nintedanib
💬
5. FGFR2
×
Name
Other Names
Nintedanib
Nintedanib (USAN/INN)
Ofev (TN)
Nintedanib
[5]
51
51
,
85
,
89
,
227
,
228
💬
5. FGFR2
×
Disease ID
Name
51
Scleroderma
85
Idiopathic interstitial pneumonia
89
Lymphangioleiomyomatosis
227
Osler disease
228
Bronchiolitis obliterans
6
FLT1
💬
6. FLT1
×
Name
Full Name
FLT1
fms related receptor tyrosine kinase 1
[9]
MAPK signaling pathway
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
HIF-1 signaling pathway
,
PI3K-Akt signaling pathway
,
Focal adhesion
,
Transcriptional misregulation in cancer
,
Rheumatoid arthritis
[9]
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
...
Nintedanib
Nintedanib
💬
6. FLT1
×
Name
Other Names
Nintedanib
Nintedanib (USAN/INN)
Ofev (TN)
Nintedanib
[5]
51
51
,
85
,
89
,
227
,
228
💬
6. FLT1
×
Disease ID
Name
51
Scleroderma
85
Idiopathic interstitial pneumonia
89
Lymphangioleiomyomatosis
227
Osler disease
228
Bronchiolitis obliterans
7
FLT4
💬
7. FLT4
×
Name
Full Name
FLT4
fms related receptor tyrosine kinase 4
[8]
MAPK signaling pathway
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
PI3K-Akt signaling pathway
,
Focal adhesion
,
Pathways in cancer
,
Breast cancer
[8]
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
...
Nintedanib
Nintedanib
💬
7. FLT4
×
Name
Other Names
Nintedanib
Nintedanib (USAN/INN)
Ofev (TN)
Nintedanib
[5]
51
51
,
85
,
89
,
227
,
228
💬
7. FLT4
×
Disease ID
Name
51
Scleroderma
85
Idiopathic interstitial pneumonia
89
Lymphangioleiomyomatosis
227
Osler disease
228
Bronchiolitis obliterans
8
MTOR
💬
8. MTOR
×
Name
Full Name
MTOR
mechanistic target of rapamycin kinase
[51]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1 signaling pathway
,
Phospholipase D signaling pathway
,
Autophagy - other
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
AMPK signaling pathway
,
Longevity regulating pathway
,
Longevity regulating pathway - multiple species
,
Cellular senescence
,
Apelin signaling pathway
,
Neutrophil extracellular trap formation
,
JAK-STAT signaling pathway
,
Th17 cell differentiation
,
Thermogenesis
,
Insulin signaling pathway
,
Thyroid hormone signaling pathway
,
Adipocytokine signaling pathway
,
Type II diabetes mellitus
,
Insulin resistance
,
Growth hormone synthesis, secretion and action
,
Alzheimer disease
,
Amyotrophic lateral sclerosis
,
Huntington disease
,
Spinocerebellar ataxia
,
Pathways of neurodegeneration - multiple diseases
,
Shigellosis
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Human immunodeficiency virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Colorectal cancer
,
Pancreatic cancer
,
Glioma
,
Prostate cancer
,
Acute myeloid leukemia
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
[51]
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1
...
Sirolimus
Sirolimus
💬
8. MTOR
×
Name
Other Names
Sirolimus
Sirolimus (JAN/USAN/INN)
Rapamune (TN)
Rapamycin (TN)
FYARRO
HYFTOR
Sirolimus
[40]
2
2
,
13
,
15
,
17
,
19
,
34
,
35
,
36
,
46
,
49
,
51
,
53
,
60
,
61
,
62
,
63
,
65
,
66
,
67
,
84
,
85
,
86
,
89
,
96
,
98
,
137
,
157
,
158
,
192
,
193
,
222
,
256
,
277
,
278
,
279
,
280
,
281
,
283
,
300
,
331
💬
[40]
2
,
13
,
15
,
17
,
19
,
34
,
35
,
36
,
46
,
49
,
51
,
53
,
60
,
61
,
62
,
63
,
65
,
66
,
67
,
84
,
85
,
86
,
89
,
96
, ...
8. MTOR
×
Disease ID
Name
2
Amyotrophic lateral sclerosis
13
Multiple sclerosis/Neuromyelitis optica
15
Inclusion body myositis
17
Multiple system atrophy
19
Lysosomal storage disease
34
Neurofibromatosis
35
Pemphigus
36
Epidermolysis bullosa
46
Malignant rheumatoid arthritis
49
Systemic lupus erythematosus
51
Scleroderma
53
Sjogren syndrome
60
Aplastic anemia
61
Autoimmune hemolytic anemia
62
Paroxysmal nocturnal hemoglobinuria
63
Idiopathic thrombocytopenic purpura
65
Primary immunodeficiency
66
IgA nephropathy
67
Polycystic kidney disease
84
Sarcoidosis
85
Idiopathic interstitial pneumonia
86
Pulmonary arterial hypertension
89
Lymphangioleiomyomatosis
96
Crohn disease
98
Eosinophilic gastrointestinal disease
137
Focal cortical dysplasia
157
Sturge-Weber syndrome
158
Tuberous sclerosis
192
Cockayne syndrome
193
Prader-Willi syndrome
222
Primary nephrotic syndrome
256
Muscle glycogenosis
277
Lymphangiomatosis
278
Huge lymphatic malformation with cervicofacial lesion
279
Huge venous malformation with cervical, oral and pharyngeal diffuse lesion
280
Huge arteriovenous malformation with cervicofacial or limb lesion
281
Klippel-Trenaunay-Weber syndrome
283
Acquired pure red cell aplasia
300
IgG4-related disease
331
Idiopathic multicentric castleman disease
9
MTOR
💬
9. MTOR
×
Name
Full Name
MTOR
mechanistic target of rapamycin kinase
[51]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1 signaling pathway
,
Phospholipase D signaling pathway
,
Autophagy - other
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
AMPK signaling pathway
,
Longevity regulating pathway
,
Longevity regulating pathway - multiple species
,
Cellular senescence
,
Apelin signaling pathway
,
Neutrophil extracellular trap formation
,
JAK-STAT signaling pathway
,
Th17 cell differentiation
,
Thermogenesis
,
Insulin signaling pathway
,
Thyroid hormone signaling pathway
,
Adipocytokine signaling pathway
,
Type II diabetes mellitus
,
Insulin resistance
,
Growth hormone synthesis, secretion and action
,
Alzheimer disease
,
Amyotrophic lateral sclerosis
,
Huntington disease
,
Spinocerebellar ataxia
,
Pathways of neurodegeneration - multiple diseases
,
Shigellosis
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Human immunodeficiency virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Colorectal cancer
,
Pancreatic cancer
,
Glioma
,
Prostate cancer
,
Acute myeloid leukemia
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
[51]
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1
...
Everolimus
Everolimus
💬
9. MTOR
×
Name
Other Names
Everolimus
Everolimus (JAN/USAN/INN)
Afinitor (TN)
Votubia (TN)
Zortress (TN)
Everolimus
[9]
34
34
,
67
,
89
,
96
,
137
,
157
,
158
,
228
,
277
💬
9. MTOR
×
Disease ID
Name
34
Neurofibromatosis
67
Polycystic kidney disease
89
Lymphangioleiomyomatosis
96
Crohn disease
137
Focal cortical dysplasia
157
Sturge-Weber syndrome
158
Tuberous sclerosis
228
Bronchiolitis obliterans
277
Lymphangiomatosis
10
ABL1
💬
10. ABL1
×
Name
Full Name
ABL1
ABL proto-oncogene 1, non-receptor tyrosine kinase
[11]
ErbB signaling pathway
ErbB signaling pathway
,
Ras signaling pathway
,
Cell cycle
,
Axon guidance
,
Neurotrophin signaling pathway
,
Pathogenic Escherichia coli infection
,
Pathways in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
Chronic myeloid leukemia
,
Viral myocarditis
[11]
ErbB signaling pathway
,
Ras signaling pathway
,
Cell cycle
,
Axon guidance
,
Neurotrophin signalin
...
Imatinib
Imatinib
💬
10. ABL1
×
Name
Other Names
Imatinib
Imatinib (INN)
Glamox (TN)
Imatinib
[12]
13
13
,
28
,
34
,
35
,
46
,
51
,
85
,
86
,
87
,
88
,
89
,
162
💬
10. ABL1
×
Disease ID
Name
13
Multiple sclerosis/Neuromyelitis optica
28
Systemic amyloidosis
34
Neurofibromatosis
35
Pemphigus
46
Malignant rheumatoid arthritis
51
Scleroderma
85
Idiopathic interstitial pneumonia
86
Pulmonary arterial hypertension
87
Pulmonary veno-occlusive disease
88
Chronic thromboembolic pulmonary hypertension
89
Lymphangioleiomyomatosis
162
Pemphigoid