Target Gene/Pathway Pathway / Gene

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KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[7] Alanine, aspartate and glutamate metabolism, Valine, leucine and isoleucine degradation, beta-Al ...

Valproic acid 💬

[14] 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
3	Spinal muscular atrophy
5	Progressive supranuclear palsy
6	Parkinson disease
13	Multiple sclerosis/Neuromyelitis optica
26	HTLV-1-associated myelopathy
65	Primary immunodeficiency
85	Idiopathic interstitial pneumonia
90	Retinitis pigmentosa
102	Rubinstein-Taybi syndrome
127	Frontotemporal lobar degeneration
222	Primary nephrotic syndrome
233	Wolfram syndrome
256	Muscle glycogenosis

2

[7] Alanine, aspartate and glutamate metabolism, Valine, leucine and isoleucine degradation, beta-Al ...

Vigabatrin 💬

[2] 145, 158 💬

3

[7] cAMP signaling pathway, Neuroactive ligand-receptor interaction, GABAergic synapse, Taste transd ...

[8] 2, 10, 13, 18, 65, 70, 149, 206 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
10	Charcot-Marie-Tooth disease
13	Multiple sclerosis/Neuromyelitis optica
18	Spinocerebellar degeneration
65	Primary immunodeficiency
70	Spinal stenosis
149	Hemiconvulsion hemiplegia epilepsy syndrome
206	Fragile X syndrome

4

[7] cAMP signaling pathway, Neuroactive ligand-receptor interaction, GABAergic synapse, Taste transd ...

Arbaclofen placarbil 💬

Arbaclofen Placarbil

[1] 13 💬

5

[7] cAMP signaling pathway, Neuroactive ligand-receptor interaction, GABAergic synapse, Taste transd ...

Arbaclofen 💬

[2] 13, 206 💬

6

[7] cAMP signaling pathway, Neuroactive ligand-receptor interaction, GABAergic synapse, Taste transd ...

Valiloxybate 💬

[1] 6 💬

7

[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse ...

Alprazolam 💬

[2] 8, 75 💬

8

[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse ...

Clonazepam 💬

[1] 6 💬

9

[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse ...

[3] 46, 155, 298 💬

10

[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse ...

[1] 36 💬

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