Target Gene/Pathway Pathway / Gene

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KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[4] Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Th17 cell differentiation, Infl ...

Bimekizumab 💬

[3] 46, 97, 271 💬

2

[62] Endocrine resistance, MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, S ...

Losmapimod 💬

[2] 113, 222 💬

3

[62] Endocrine resistance, MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, S ...

Neflamapimod 💬

[1] 8 💬

4

[16] Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, Hematopoietic cell lineage, ...

[1] 46 💬

5

[3] Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Alcoholic liver disease

Brodalumab 💬

[2] 37, 51 💬

6

[32] Proteasome, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Necroptosis, TGF-b ...

Fontolizumab 💬

[1] 46 💬

7

[32] Proteasome, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Necroptosis, TGF-b ...

Emapalumab 💬

[3] 49, 65, 107 💬

8

[44] Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa ...

Pirfenidone 💬

[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica
34	Neurofibromatosis
46	Malignant rheumatoid arthritis
50	Dermatomyositis
51	Scleroderma
58	Hypertrophic cardiomyopathy
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
164	Oculocutaneous albinism
222	Primary nephrotic syndrome
228	Bronchiolitis obliterans

9

[44] Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa ...

Rilonacept 💬

[4] 51, 106, 107, 266 💬

10

[44] Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa ...

Canakinumab 💬

[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬

Disease ID	Name
46	Malignant rheumatoid arthritis
56	Behcet disease
84	Sarcoidosis
106	Cryopyrin-associated periodic syndrome
107	Juvenile idiopathic arthritis
108	TNF receptor-associated periodic syndrome
113	Muscular dystrophy
266	Familial mediterranean fever
267	Hyper-IgD syndrome
269	Pyogenic arthritis

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