Target Gene/Pathway Pathway / Gene

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KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[23] EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 ...

Cabozantinib 💬

[1] 34 💬

2

[106] Inositol phosphate metabolism, Metabolic pathways, EGFR tyrosine kinase inhibitor resistance, ...

[1] 138 💬

3

[106] Inositol phosphate metabolism, Metabolic pathways, EGFR tyrosine kinase inhibitor resistance, ...

Leniolisib 💬

[2] 53, 65 💬

4

[106] Inositol phosphate metabolism, Metabolic pathways, EGFR tyrosine kinase inhibitor resistance, ...

Leniolisib 💬

[2] 53, 65 💬

5

[106] Inositol phosphate metabolism, Metabolic pathways, EGFR tyrosine kinase inhibitor resistance, ...

Leniolisib 💬

[2] 53, 65 💬

6

[106] Inositol phosphate metabolism, Metabolic pathways, EGFR tyrosine kinase inhibitor resistance, ...

Parsaclisib 💬

[3] 35, 53, 61 💬

7

[89] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...

Selumetinib 💬

[1] 34 💬

8

[89] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...

Trametinib 💬

[4] 2, 34, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
34	Neurofibromatosis
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion
280	Huge arteriovenous malformation with cervicofacial or limb lesion

9

[89] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...

Cobimetinib 💬

[1] 280 💬

10

[89] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...

Binimetinib 💬

[1] 34 💬

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