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KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
Disease ID
1
IFNG
💬
1. IFNG
×
Name
Full Name
IFNG
interferon gamma
[32]
Proteasome
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Antigen processing and presentation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Type I diabetes mellitus
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis C
,
Influenza A
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
,
Allograft rejection
,
Graft-versus-host disease
,
Fluid shear stress and atherosclerosis
[32]
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-b
...
Fontolizumab
Fontolizumab
💬
1. IFNG
×
Name
Other Names
Fontolizumab
Fontolizumab (USAN/INN)
Fontolizumab
[1]
46
46
💬
1. IFNG
×
Disease ID
Name
46
Malignant rheumatoid arthritis
2
IFNG
💬
2. IFNG
×
Name
Full Name
IFNG
interferon gamma
[32]
Proteasome
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Antigen processing and presentation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Type I diabetes mellitus
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis C
,
Influenza A
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
,
Allograft rejection
,
Graft-versus-host disease
,
Fluid shear stress and atherosclerosis
[32]
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-b
...
Emapalumab
Emapalumab
💬
2. IFNG
×
Name
Other Names
Emapalumab
Emapalumab (USAN/INN)
Emapalumab (genetical recombination) (JAN)
Emapalumab-lzsg
Gamifant (TN)
Emapalumab
[3]
49
49
,
65
,
107
💬
2. IFNG
×
Disease ID
Name
49
Systemic lupus erythematosus
65
Primary immunodeficiency
107
Juvenile idiopathic arthritis
3
SMAD7
💬
3. SMAD7
×
Name
Full Name
SMAD7
SMAD family member 7
[2]
TGF-beta signaling pathway
TGF-beta signaling pathway
,
Hippo signaling pathway
Mongersen
Mongersen
💬
3. SMAD7
×
Name
Other Names
Mongersen
Mongersen (INN)
Mongersen
[2]
96
96
,
97
💬
3. SMAD7
×
Disease ID
Name
96
Crohn disease
97
Ulcerative colitis
4
RGMA
💬
4. RGMA
×
Name
Full Name
RGMA
repulsive guidance molecule BMP co-receptor a
[2]
TGF-beta signaling pathway
TGF-beta signaling pathway
,
Axon guidance
Elezanumab
Elezanumab
💬
4. RGMA
×
Name
Other Names
Elezanumab
Elezanumab (USAN/INN)
Elezanumab
[1]
13
13
💬
4. RGMA
×
Disease ID
Name
13
Multiple sclerosis/Neuromyelitis optica
5
ROCK1
💬
5. ROCK1
×
Name
Full Name
ROCK1
Rho associated coiled-coil containing protein kinase 1
[20]
cGMP-PKG signaling pathway
cGMP-PKG signaling pathway
,
cAMP signaling pathway
,
Chemokine signaling pathway
,
Sphingolipid signaling pathway
,
Vascular smooth muscle contraction
,
TGF-beta signaling pathway
,
Axon guidance
,
Focal adhesion
,
Tight junction
,
Platelet activation
,
Leukocyte transendothelial migration
,
Regulation of actin cytoskeleton
,
Oxytocin signaling pathway
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Yersinia infection
,
Human cytomegalovirus infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
[20]
cGMP-PKG signaling pathway
,
cAMP signaling pathway
,
Chemokine signaling pathway
,
Sphingolipid s
...
Fasudil
Fasudil
💬
5. ROCK1
×
Name
Other Names
Fasudil
Fasudil (INN)
Fasudil
[4]
2
2
,
5
,
7
,
51
💬
5. ROCK1
×
Disease ID
Name
2
Amyotrophic lateral sclerosis
5
Progressive supranuclear palsy
7
Corticobasal degeneration
51
Scleroderma
6
TGFB1
💬
6. TGFB1
×
Name
Full Name
TGFB1
transforming growth factor beta 1
[34]
MAPK signaling pathway
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
FoxO signaling pathway
,
Cell cycle
,
Cellular senescence
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Hippo signaling pathway
,
Th17 cell differentiation
,
Intestinal immune network for IgA production
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Leishmaniasis
,
Chagas disease
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis B
,
Human T-cell leukemia virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
Colorectal cancer
,
Renal cell carcinoma
,
Pancreatic cancer
,
Chronic myeloid leukemia
,
Hepatocellular carcinoma
,
Gastric cancer
,
Inflammatory bowel disease
,
Rheumatoid arthritis
,
Hypertrophic cardiomyopathy
,
Dilated cardiomyopathy
,
Diabetic cardiomyopathy
[34]
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
FoxO signaling pathway
,
Cell cy
...
Fresolimumab
Fresolimumab
💬
6. TGFB1
×
Name
Other Names
Fresolimumab
Fresolimumab (USAN/INN)
Fresolimumab
[3]
51
51
,
85
,
222
💬
6. TGFB1
×
Disease ID
Name
51
Scleroderma
85
Idiopathic interstitial pneumonia
222
Primary nephrotic syndrome
7
TGFB2
💬
7. TGFB2
×
Name
Full Name
TGFB2
transforming growth factor beta 2
[31]
MAPK signaling pathway
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
FoxO signaling pathway
,
Cell cycle
,
Cellular senescence
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Hippo signaling pathway
,
AGE-RAGE signaling pathway in diabetic complications
,
Leishmaniasis
,
Chagas disease
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis B
,
Human T-cell leukemia virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Colorectal cancer
,
Renal cell carcinoma
,
Pancreatic cancer
,
Chronic myeloid leukemia
,
Hepatocellular carcinoma
,
Gastric cancer
,
Inflammatory bowel disease
,
Rheumatoid arthritis
,
Hypertrophic cardiomyopathy
,
Dilated cardiomyopathy
,
Diabetic cardiomyopathy
[31]
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
FoxO signaling pathway
,
Cell cy
...
Fresolimumab
Fresolimumab
💬
7. TGFB2
×
Name
Other Names
Fresolimumab
Fresolimumab (USAN/INN)
Fresolimumab
[3]
51
51
,
85
,
222
💬
7. TGFB2
×
Disease ID
Name
51
Scleroderma
85
Idiopathic interstitial pneumonia
222
Primary nephrotic syndrome
8
TGFB3
💬
8. TGFB3
×
Name
Full Name
TGFB3
transforming growth factor beta 3
[28]
MAPK signaling pathway
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
FoxO signaling pathway
,
Cell cycle
,
Cellular senescence
,
TGF-beta signaling pathway
,
Hippo signaling pathway
,
AGE-RAGE signaling pathway in diabetic complications
,
Leishmaniasis
,
Chagas disease
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis B
,
Human T-cell leukemia virus 1 infection
,
Pathways in cancer
,
Colorectal cancer
,
Renal cell carcinoma
,
Pancreatic cancer
,
Chronic myeloid leukemia
,
Hepatocellular carcinoma
,
Gastric cancer
,
Inflammatory bowel disease
,
Rheumatoid arthritis
,
Hypertrophic cardiomyopathy
,
Dilated cardiomyopathy
,
Diabetic cardiomyopathy
[28]
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
FoxO signaling pathway
,
Cell cy
...
Fresolimumab
Fresolimumab
💬
8. TGFB3
×
Name
Other Names
Fresolimumab
Fresolimumab (USAN/INN)
Fresolimumab
[3]
51
51
,
85
,
222
💬
8. TGFB3
×
Disease ID
Name
51
Scleroderma
85
Idiopathic interstitial pneumonia
222
Primary nephrotic syndrome
9
TNF
💬
9. TNF
×
Name
Full Name
TNF
tumor necrosis factor
[67]
Antifolate resistance
Antifolate resistance
,
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Viral protein interaction with cytokine and cytokine receptor
,
NF-kappa B signaling pathway
,
Sphingolipid signaling pathway
,
mTOR signaling pathway
,
Apoptosis
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Antigen processing and presentation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
Hematopoietic cell lineage
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Adipocytokine signaling pathway
,
Type II diabetes mellitus
,
Insulin resistance
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Alcoholic liver disease
,
Type I diabetes mellitus
,
Alzheimer disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Legionellosis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis C
,
Hepatitis B
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Herpes simplex virus 1 infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Asthma
,
Inflammatory bowel disease
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
,
Allograft rejection
,
Graft-versus-host disease
,
Hypertrophic cardiomyopathy
,
Dilated cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[67]
Antifolate resistance
,
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Viral pr
...
Etanercept
Etanercept
💬
9. TNF
×
Name
Other Names
Etanercept
Etanercept (USAN/INN)
Etanercept (genetical recombination) (JAN)
Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN)
Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN)
Enbrel (TN)
Etanercept
[16]
15
15
,
28
,
35
,
38
,
39
,
46
,
50
,
53
,
56
,
60
,
85
,
107
,
228
,
270
,
271
,
285
💬
9. TNF
×
Disease ID
Name
15
Inclusion body myositis
28
Systemic amyloidosis
35
Pemphigus
38
Stevens-Johnson syndrome
39
Toxic epidermal necrolysis
46
Malignant rheumatoid arthritis
50
Dermatomyositis
53
Sjogren syndrome
56
Behcet disease
60
Aplastic anemia
85
Idiopathic interstitial pneumonia
107
Juvenile idiopathic arthritis
228
Bronchiolitis obliterans
270
Chronic recurrent multifocal osteomyelitis
271
Ankylosing spondylitis
285
Fanconi anemia
10
TNF
💬
10. TNF
×
Name
Full Name
TNF
tumor necrosis factor
[67]
Antifolate resistance
Antifolate resistance
,
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Viral protein interaction with cytokine and cytokine receptor
,
NF-kappa B signaling pathway
,
Sphingolipid signaling pathway
,
mTOR signaling pathway
,
Apoptosis
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Antigen processing and presentation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
Hematopoietic cell lineage
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Adipocytokine signaling pathway
,
Type II diabetes mellitus
,
Insulin resistance
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Alcoholic liver disease
,
Type I diabetes mellitus
,
Alzheimer disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Legionellosis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis C
,
Hepatitis B
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Herpes simplex virus 1 infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Asthma
,
Inflammatory bowel disease
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
,
Allograft rejection
,
Graft-versus-host disease
,
Hypertrophic cardiomyopathy
,
Dilated cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[67]
Antifolate resistance
,
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Viral pr
...
Thalidomide
Thalidomide
💬
10. TNF
×
Name
Other Names
Thalidomide
Thalidomide (JAN/USP/INN)
Thalomid (TN)
Thaled (TN)
Thalidomide
[20]
2
2
,
16
,
20
,
28
,
49
,
51
,
53
,
56
,
65
,
84
,
85
,
94
,
96
,
97
,
227
,
271
,
280
,
298
,
300
,
331
💬
10. TNF
×
Disease ID
Name
2
Amyotrophic lateral sclerosis
16
Crow-Fukase syndrome
20
Adrenoleukodystrophy
28
Systemic amyloidosis
49
Systemic lupus erythematosus
51
Scleroderma
53
Sjogren syndrome
56
Behcet disease
65
Primary immunodeficiency
84
Sarcoidosis
85
Idiopathic interstitial pneumonia
94
Primary sclerosing cholangitis
96
Crohn disease
97
Ulcerative colitis
227
Osler disease
271
Ankylosing spondylitis
280
Huge arteriovenous malformation with cervicofacial or limb lesion
298
Hereditary pancreatitis
300
IgG4-related disease
331
Idiopathic multicentric castleman disease