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KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
Disease ID
1
COMT
💬
1. COMT
×
Name
Full Name
COMT
catechol-O-methyltransferase
[4]
Steroid hormone biosynthesis
Steroid hormone biosynthesis
,
Tyrosine metabolism
,
Metabolic pathways
,
Dopaminergic synapse
Entacapone
Entacapone
💬
1. COMT
×
Name
Other Names
Entacapone
Entacapone (JP18/USP/INN)
Comtan (TN)
Entacapone
[2]
6
6
,
17
💬
1. COMT
×
Disease ID
Name
6
Parkinson disease
17
Multiple system atrophy
2
COMT
💬
2. COMT
×
Name
Full Name
COMT
catechol-O-methyltransferase
[4]
Steroid hormone biosynthesis
Steroid hormone biosynthesis
,
Tyrosine metabolism
,
Metabolic pathways
,
Dopaminergic synapse
Tolcapone
Tolcapone
💬
2. COMT
×
Name
Other Names
Tolcapone
Tolcapone (JAN/USP/INN)
Tasmar (TN)
Tolcapone
[3]
6
6
,
28
,
127
💬
2. COMT
×
Disease ID
Name
6
Parkinson disease
28
Systemic amyloidosis
127
Frontotemporal lobar degeneration
3
COMT
💬
3. COMT
×
Name
Full Name
COMT
catechol-O-methyltransferase
[4]
Steroid hormone biosynthesis
Steroid hormone biosynthesis
,
Tyrosine metabolism
,
Metabolic pathways
,
Dopaminergic synapse
Opicapone
Opicapone
💬
3. COMT
×
Name
Other Names
Opicapone
Opicapone (JAN/USAN/INN)
Ongentys (TN)
Opicapone
[1]
6
6
💬
3. COMT
×
Disease ID
Name
6
Parkinson disease
4
MAPK14
💬
4. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
[62]
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[62]
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Losmapimod
Losmapimod
💬
4. MAPK14
×
Name
Other Names
Losmapimod
Losmapimod (USAN/INN)
Losmapimod
[2]
113
113
,
222
💬
4. MAPK14
×
Disease ID
Name
113
Muscular dystrophy
222
Primary nephrotic syndrome
5
MAPK14
💬
5. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
[62]
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[62]
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Neflamapimod
Neflamapimod
💬
5. MAPK14
×
Name
Other Names
Neflamapimod
Neflamapimod (USAN)
Neflamapimod
[1]
8
8
💬
5. MAPK14
×
Disease ID
Name
8
Huntington disease
6
DDC
💬
6. DDC
×
Name
Full Name
DDC
dopa decarboxylase
[9]
Tyrosine metabolism
Tyrosine metabolism
,
Phenylalanine metabolism
,
Tryptophan metabolism
,
Metabolic pathways
,
Serotonergic synapse
,
Dopaminergic synapse
,
Cocaine addiction
,
Amphetamine addiction
,
Alcoholism
[9]
Tyrosine metabolism
,
Phenylalanine metabolism
,
Tryptophan metabolism
,
Metabolic pathways
,
Seroto
...
Carbidopa
Carbidopa
💬
6. DDC
×
Name
Other Names
Carbidopa
Carbidopa (USP)
Carbidopa hydrate (JP18)
Lodosyn (TN)
CARBIDOPA TABLETS, 25 MG
Carbidopa
[7]
6
6
,
13
,
17
,
90
,
140
,
164
,
201
💬
6. DDC
×
Disease ID
Name
6
Parkinson disease
13
Multiple sclerosis/Neuromyelitis optica
17
Multiple system atrophy
90
Retinitis pigmentosa
140
Dorabe syndrome
164
Oculocutaneous albinism
201
Angelman syndrome
7
DDC
💬
7. DDC
×
Name
Full Name
DDC
dopa decarboxylase
[9]
Tyrosine metabolism
Tyrosine metabolism
,
Phenylalanine metabolism
,
Tryptophan metabolism
,
Metabolic pathways
,
Serotonergic synapse
,
Dopaminergic synapse
,
Cocaine addiction
,
Amphetamine addiction
,
Alcoholism
[9]
Tyrosine metabolism
,
Phenylalanine metabolism
,
Tryptophan metabolism
,
Metabolic pathways
,
Seroto
...
Benserazide
Benserazide
💬
7. DDC
×
Name
Other Names
Benserazide
Benserazide (USAN/INN)
Benserazide
[1]
6
6
💬
7. DDC
×
Disease ID
Name
6
Parkinson disease
8
DRD1
💬
8. DRD1
×
Name
Full Name
DRD1
dopamine receptor D1
[10]
Calcium signaling pathway
Calcium signaling pathway
,
cAMP signaling pathway
,
Neuroactive ligand-receptor interaction
,
Gap junction
,
Dopaminergic synapse
,
Parkinson disease
,
Cocaine addiction
,
Amphetamine addiction
,
Morphine addiction
,
Alcoholism
[10]
Calcium signaling pathway
,
cAMP signaling pathway
,
Neuroactive ligand-receptor interaction
,
Gap
...
Levodopa
Levodopa
💬
8. DRD1
×
Name
Other Names
Levodopa
Levodopa (JP18/USP/INN)
Dopar (TN)
INBRIJA
Levodopa
[6]
6
6
,
17
,
90
,
140
,
164
,
201
💬
8. DRD1
×
Disease ID
Name
6
Parkinson disease
17
Multiple system atrophy
90
Retinitis pigmentosa
140
Dorabe syndrome
164
Oculocutaneous albinism
201
Angelman syndrome
9
DRD1
💬
9. DRD1
×
Name
Full Name
DRD1
dopamine receptor D1
[10]
Calcium signaling pathway
Calcium signaling pathway
,
cAMP signaling pathway
,
Neuroactive ligand-receptor interaction
,
Gap junction
,
Dopaminergic synapse
,
Parkinson disease
,
Cocaine addiction
,
Amphetamine addiction
,
Morphine addiction
,
Alcoholism
[10]
Calcium signaling pathway
,
cAMP signaling pathway
,
Neuroactive ligand-receptor interaction
,
Gap
...
Flupentixol
Flupentixol
💬
9. DRD1
×
Name
Other Names
Flupentixol
Flupentixol (INN)
Flupenthixol
Depixol (TN)
Flupentixol
[1]
97
97
💬
9. DRD1
×
Disease ID
Name
97
Ulcerative colitis
10
DRD1
💬
10. DRD1
×
Name
Full Name
DRD1
dopamine receptor D1
[10]
Calcium signaling pathway
Calcium signaling pathway
,
cAMP signaling pathway
,
Neuroactive ligand-receptor interaction
,
Gap junction
,
Dopaminergic synapse
,
Parkinson disease
,
Cocaine addiction
,
Amphetamine addiction
,
Morphine addiction
,
Alcoholism
[10]
Calcium signaling pathway
,
cAMP signaling pathway
,
Neuroactive ligand-receptor interaction
,
Gap
...
Apomorphine
Apomorphine
💬
10. DRD1
×
Name
Other Names
Apomorphine
Apomorphine (BAN)
Uprima (TN)
Apomorphine
[3]
5
5
,
6
,
7
💬
10. DRD1
×
Disease ID
Name
5
Progressive supranuclear palsy
6
Parkinson disease
7
Corticobasal degeneration