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KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
Disease ID
1
MAPK14
💬
1. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
[62]
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[62]
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Losmapimod
Losmapimod
💬
1. MAPK14
×
Name
Other Names
Losmapimod
Losmapimod (USAN/INN)
Losmapimod
[2]
113
113
,
222
💬
1. MAPK14
×
Disease ID
Name
113
Muscular dystrophy
222
Primary nephrotic syndrome
2
MAPK14
💬
2. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
[62]
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[62]
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Neflamapimod
Neflamapimod
💬
2. MAPK14
×
Name
Other Names
Neflamapimod
Neflamapimod (USAN)
Neflamapimod
[1]
8
8
💬
2. MAPK14
×
Disease ID
Name
8
Huntington disease
3
CYP17A1
💬
3. CYP17A1
×
Name
Full Name
CYP17A1
cytochrome P450 family 17 subfamily A member 1
[6]
Steroid hormone biosynthesis
Steroid hormone biosynthesis
,
Metabolic pathways
,
Ovarian steroidogenesis
,
Prolactin signaling pathway
,
Cortisol synthesis and secretion
,
Cushing syndrome
[6]
Steroid hormone biosynthesis
,
Metabolic pathways
,
Ovarian steroidogenesis
,
Prolactin signaling p
...
Ketoconazole
Ketoconazole
💬
3. CYP17A1
×
Name
Other Names
Ketoconazole
Ketoconazole (JP18/USP)
Nizoral (TN)
Xolegel (TN)
Ketoconazole
[3]
8
8
,
13
,
75
💬
3. CYP17A1
×
Disease ID
Name
8
Huntington disease
13
Multiple sclerosis/Neuromyelitis optica
75
Cushing disease
4
CYP17A1
💬
4. CYP17A1
×
Name
Full Name
CYP17A1
cytochrome P450 family 17 subfamily A member 1
[6]
Steroid hormone biosynthesis
Steroid hormone biosynthesis
,
Metabolic pathways
,
Ovarian steroidogenesis
,
Prolactin signaling pathway
,
Cortisol synthesis and secretion
,
Cushing syndrome
[6]
Steroid hormone biosynthesis
,
Metabolic pathways
,
Ovarian steroidogenesis
,
Prolactin signaling p
...
Levoketoconazole
Levoketoconazole
💬
4. CYP17A1
×
Name
Other Names
Levoketoconazole
Levoketoconazole (USAN/INN)
Recorlev (TN)
Levoketoconazole
[1]
75
75
💬
4. CYP17A1
×
Disease ID
Name
75
Cushing disease
5
ESR1
💬
5. ESR1
×
Name
Full Name
ESR1
estrogen receptor 1
[9]
Endocrine resistance
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone signaling pathway
,
Endocrine and other factor-regulated calcium reabsorption
,
Pathways in cancer
,
Proteoglycans in cancer
,
Chemical carcinogenesis - receptor activation
,
Breast cancer
[9]
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone s
...
Estradiol
Estradiol
💬
5. ESR1
×
Name
Other Names
Estradiol
Estradiol (JAN/USP/INN)
Climara (TN)
Divigel (TN)
Estrace (TN)
Estraderm (TN)
Estrasorb (TN)
Estring (TN)
Estrogel (TN)
Innofem (TN)
Vagifem (TN)
Vivelle (TN)
IMVEXXY
MENOSTAR
MINIVELLE
VIVELLE-DOT
DOTTI
ESTRADIOL TRANSDERMAL SYSTEM
ESTRADIOL VAGINAL
ESTRADIOL VAGINAL CREAM
LYLLANA
YUVAFEM
Estradiol
[7]
13
13
,
46
,
49
,
65
,
76
,
226
,
299
💬
5. ESR1
×
Disease ID
Name
13
Multiple sclerosis/Neuromyelitis optica
46
Malignant rheumatoid arthritis
49
Systemic lupus erythematosus
65
Primary immunodeficiency
76
Pituitary gonadotropin secretion hyperthyroidism
226
Interstitial cystitis with Hunners ulcer
299
Cystic fibrosis
6
ESR1
💬
6. ESR1
×
Name
Full Name
ESR1
estrogen receptor 1
[9]
Endocrine resistance
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone signaling pathway
,
Endocrine and other factor-regulated calcium reabsorption
,
Pathways in cancer
,
Proteoglycans in cancer
,
Chemical carcinogenesis - receptor activation
,
Breast cancer
[9]
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone s
...
Estriol
Estriol
💬
6. ESR1
×
Name
Other Names
Estriol
Estriol (JP18/USP)
Estriel (TN)
Estriol
[2]
13
13
,
227
💬
6. ESR1
×
Disease ID
Name
13
Multiple sclerosis/Neuromyelitis optica
227
Osler disease
7
ESR1
💬
7. ESR1
×
Name
Full Name
ESR1
estrogen receptor 1
[9]
Endocrine resistance
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone signaling pathway
,
Endocrine and other factor-regulated calcium reabsorption
,
Pathways in cancer
,
Proteoglycans in cancer
,
Chemical carcinogenesis - receptor activation
,
Breast cancer
[9]
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone s
...
Danazol
Danazol
💬
7. ESR1
×
Name
Other Names
Danazol
Danazol (JP18/USP/INN)
Danocrine (TN)
Danazol
[5]
60
60
,
63
,
64
,
65
,
285
💬
7. ESR1
×
Disease ID
Name
60
Aplastic anemia
63
Idiopathic thrombocytopenic purpura
64
Thrombotic thrombocytopenic purpura
65
Primary immunodeficiency
285
Fanconi anemia
8
ESR1
💬
8. ESR1
×
Name
Full Name
ESR1
estrogen receptor 1
[9]
Endocrine resistance
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone signaling pathway
,
Endocrine and other factor-regulated calcium reabsorption
,
Pathways in cancer
,
Proteoglycans in cancer
,
Chemical carcinogenesis - receptor activation
,
Breast cancer
[9]
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone s
...
Ethinyl estradiol
Ethinyl estradiol
💬
8. ESR1
×
Name
Other Names
Ethinyl estradiol
Ethinyl estradiol (USP)
Ethinylestradiol (JP18/INN)
Estinyl (TN)
Ethinylestradiol
[4]
13
13
,
46
,
49
,
299
💬
8. ESR1
×
Disease ID
Name
13
Multiple sclerosis/Neuromyelitis optica
46
Malignant rheumatoid arthritis
49
Systemic lupus erythematosus
299
Cystic fibrosis
9
ESR1
💬
9. ESR1
×
Name
Full Name
ESR1
estrogen receptor 1
[9]
Endocrine resistance
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone signaling pathway
,
Endocrine and other factor-regulated calcium reabsorption
,
Pathways in cancer
,
Proteoglycans in cancer
,
Chemical carcinogenesis - receptor activation
,
Breast cancer
[9]
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone s
...
Mestranol
Mestranol
💬
9. ESR1
×
Name
Other Names
Mestranol
Mestranol (JP18/USP/INN)
Mestranol
[2]
46
46
,
49
💬
9. ESR1
×
Disease ID
Name
46
Malignant rheumatoid arthritis
49
Systemic lupus erythematosus
10
ESR1
💬
10. ESR1
×
Name
Full Name
ESR1
estrogen receptor 1
[9]
Endocrine resistance
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone signaling pathway
,
Endocrine and other factor-regulated calcium reabsorption
,
Pathways in cancer
,
Proteoglycans in cancer
,
Chemical carcinogenesis - receptor activation
,
Breast cancer
[9]
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone s
...
Fulvestrant
Fulvestrant
💬
10. ESR1
×
Name
Other Names
Fulvestrant
Fulvestrant (JAN/USP/INN)
Faslodex (TN)
Fulvestrant
[2]
49
49
,
86
💬
10. ESR1
×
Disease ID
Name
49
Systemic lupus erythematosus
86
Pulmonary arterial hypertension