DDrare
Disease
Drug
Target Gene/Pathway
Contact
JA
Target Gene/Pathway
Pathway
/
Gene
Search
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Other
Search results
10
50
100
ALL
entries per page:
Showing 1 to 10 of 69 entries
Filter by
Reset
|
No.
KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
Disease ID
1
MAPK14
💬
1. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
[62]
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[62]
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Losmapimod
Losmapimod
💬
1. MAPK14
×
Name
Other Names
Losmapimod
Losmapimod (USAN/INN)
Losmapimod
[2]
113
113
,
222
💬
1. MAPK14
×
Disease ID
Name
113
Muscular dystrophy
222
Primary nephrotic syndrome
2
MAPK14
💬
2. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
[62]
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[62]
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Neflamapimod
Neflamapimod
💬
2. MAPK14
×
Name
Other Names
Neflamapimod
Neflamapimod (USAN)
Neflamapimod
[1]
8
8
💬
2. MAPK14
×
Disease ID
Name
8
Huntington disease
3
F2
💬
3. F2
×
Name
Full Name
F2
coagulation factor II, thrombin
[8]
Phospholipase D signaling pathway
Phospholipase D signaling pathway
,
Neuroactive ligand-receptor interaction
,
Complement and coagulation cascades
,
Platelet activation
,
Regulation of actin cytoskeleton
,
Pathogenic Escherichia coli infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
[8]
Phospholipase D signaling pathway
,
Neuroactive ligand-receptor interaction
,
Complement and coagu
...
Thrombomodulin alfa
Thrombomodulin alfa
💬
3. F2
×
Name
Other Names
Thrombomodulin alfa
Thrombomodulin alfa (USAN/INN)
Thrombomodulin alfa (genetical recombination) (JAN)
Thrombomodulin Alfa
[1]
85
85
💬
3. F2
×
Disease ID
Name
85
Idiopathic interstitial pneumonia
4
F2
💬
4. F2
×
Name
Full Name
F2
coagulation factor II, thrombin
[8]
Phospholipase D signaling pathway
Phospholipase D signaling pathway
,
Neuroactive ligand-receptor interaction
,
Complement and coagulation cascades
,
Platelet activation
,
Regulation of actin cytoskeleton
,
Pathogenic Escherichia coli infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
[8]
Phospholipase D signaling pathway
,
Neuroactive ligand-receptor interaction
,
Complement and coagu
...
Dabigatran etexilate
Dabigatran etexilate
💬
4. F2
×
Name
Other Names
Dabigatran etexilate
Dabigatran etexilate (USAN/INN)
Pradaxa (TN)
Dabigatran etexilate
[2]
51
51
,
75
💬
4. F2
×
Disease ID
Name
51
Scleroderma
75
Cushing disease
5
F2
💬
5. F2
×
Name
Full Name
F2
coagulation factor II, thrombin
[8]
Phospholipase D signaling pathway
Phospholipase D signaling pathway
,
Neuroactive ligand-receptor interaction
,
Complement and coagulation cascades
,
Platelet activation
,
Regulation of actin cytoskeleton
,
Pathogenic Escherichia coli infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
[8]
Phospholipase D signaling pathway
,
Neuroactive ligand-receptor interaction
,
Complement and coagu
...
Dabigatran
Dabigatran
💬
5. F2
×
Name
Other Names
Dabigatran
Dabigatran (USAN/INN)
Dabigatran
[5]
51
51
,
75
,
85
,
91
,
124
💬
5. F2
×
Disease ID
Name
51
Scleroderma
75
Cushing disease
85
Idiopathic interstitial pneumonia
91
Budd-Chiari syndrome
124
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
6
FYN
💬
6. FYN
×
Name
Full Name
FYN
FYN proto-oncogene, Src family tyrosine kinase
[14]
Sphingolipid signaling pathway
Sphingolipid signaling pathway
,
Phospholipase D signaling pathway
,
Axon guidance
,
Osteoclast differentiation
,
Focal adhesion
,
Adherens junction
,
Platelet activation
,
Natural killer cell mediated cytotoxicity
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Cholinergic synapse
,
Prion disease
,
Pathogenic Escherichia coli infection
,
Viral myocarditis
[14]
Sphingolipid signaling pathway
,
Phospholipase D signaling pathway
,
Axon guidance
,
Osteoclast di
...
Dasatinib
Dasatinib
💬
6. FYN
×
Name
Other Names
Dasatinib
Dasatinib (JAN/INN)
Dasatinib
[2]
51
51
,
85
💬
6. FYN
×
Disease ID
Name
51
Scleroderma
85
Idiopathic interstitial pneumonia
7
FYN
💬
7. FYN
×
Name
Full Name
FYN
FYN proto-oncogene, Src family tyrosine kinase
[14]
Sphingolipid signaling pathway
Sphingolipid signaling pathway
,
Phospholipase D signaling pathway
,
Axon guidance
,
Osteoclast differentiation
,
Focal adhesion
,
Adherens junction
,
Platelet activation
,
Natural killer cell mediated cytotoxicity
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Cholinergic synapse
,
Prion disease
,
Pathogenic Escherichia coli infection
,
Viral myocarditis
[14]
Sphingolipid signaling pathway
,
Phospholipase D signaling pathway
,
Axon guidance
,
Osteoclast di
...
Dasatinib
Dasatinib
💬
7. FYN
×
Name
Other Names
Dasatinib
Dasatinib (USAN)
Dasatinib hydrate (JAN)
Sprycel (TN)
Dasatinib
[2]
51
51
,
85
💬
7. FYN
×
Disease ID
Name
51
Scleroderma
85
Idiopathic interstitial pneumonia
8
GUCY1A2
💬
8. GUCY1A2
×
Name
Full Name
GUCY1A2
guanylate cyclase 1 soluble subunit alpha 2
[11]
Purine metabolism
Purine metabolism
,
Metabolic pathways
,
cGMP-PKG signaling pathway
,
Vascular smooth muscle contraction
,
Gap junction
,
Platelet activation
,
Circadian entrainment
,
Long-term depression
,
Oxytocin signaling pathway
,
Renin secretion
,
Salivary secretion
[11]
Purine metabolism
,
Metabolic pathways
,
cGMP-PKG signaling pathway
,
Vascular smooth muscle contr
...
Amyl nitrite
Amyl nitrite
💬
8. GUCY1A2
×
Name
Other Names
Amyl nitrite
Amyl nitrite (JP18/USP)
Aspiral (TN)
Vaporole (TN)
Amyl Nitrite
[1]
58
58
💬
8. GUCY1A2
×
Disease ID
Name
58
Hypertrophic cardiomyopathy
9
GUCY1A2
💬
9. GUCY1A2
×
Name
Full Name
GUCY1A2
guanylate cyclase 1 soluble subunit alpha 2
[11]
Purine metabolism
Purine metabolism
,
Metabolic pathways
,
cGMP-PKG signaling pathway
,
Vascular smooth muscle contraction
,
Gap junction
,
Platelet activation
,
Circadian entrainment
,
Long-term depression
,
Oxytocin signaling pathway
,
Renin secretion
,
Salivary secretion
[11]
Purine metabolism
,
Metabolic pathways
,
cGMP-PKG signaling pathway
,
Vascular smooth muscle contr
...
Riociguat
Riociguat
💬
9. GUCY1A2
×
Name
Other Names
Riociguat
Riociguat (JAN/USAN/INN)
Adempas (TN)
Riociguat
[6]
51
51
,
84
,
86
,
88
,
225
,
299
💬
9. GUCY1A2
×
Disease ID
Name
51
Scleroderma
84
Sarcoidosis
86
Pulmonary arterial hypertension
88
Chronic thromboembolic pulmonary hypertension
225
Congenital nephrogenic diabetes insipidus
299
Cystic fibrosis
10
GUCY1A1
💬
10. GUCY1A1
×
Name
Full Name
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
[11]
Purine metabolism
Purine metabolism
,
Metabolic pathways
,
cGMP-PKG signaling pathway
,
Vascular smooth muscle contraction
,
Gap junction
,
Platelet activation
,
Circadian entrainment
,
Long-term depression
,
Oxytocin signaling pathway
,
Renin secretion
,
Salivary secretion
[11]
Purine metabolism
,
Metabolic pathways
,
cGMP-PKG signaling pathway
,
Vascular smooth muscle contr
...
Amyl nitrite
Amyl nitrite
💬
10. GUCY1A1
×
Name
Other Names
Amyl nitrite
Amyl nitrite (JP18/USP)
Aspiral (TN)
Vaporole (TN)
Amyl Nitrite
[1]
58
58
💬
10. GUCY1A1
×
Disease ID
Name
58
Hypertrophic cardiomyopathy