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KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
Disease ID
1
CDK4
💬
1. CDK4
×
Name
Full Name
CDK4
cyclin dependent kinase 4
[28]
Endocrine resistance
Endocrine resistance
,
Cell cycle
,
p53 signaling pathway
,
PI3K-Akt signaling pathway
,
Cellular senescence
,
Tight junction
,
T cell receptor signaling pathway
,
AGE-RAGE signaling pathway in diabetic complications
,
Cushing syndrome
,
Hepatitis C
,
Measles
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Pathways in cancer
,
Viral carcinogenesis
,
Pancreatic cancer
,
Glioma
,
Melanoma
,
Bladder cancer
,
Chronic myeloid leukemia
,
Small cell lung cancer
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
[28]
Endocrine resistance
,
Cell cycle
,
p53 signaling pathway
,
PI3K-Akt signaling pathway
,
Cellular s
...
Abemaciclib
Abemaciclib
💬
1. CDK4
×
Name
Other Names
Abemaciclib
Abemaciclib (JAN/USAN)
Verzenio (TN)
Abemaciclib
[1]
34
34
💬
1. CDK4
×
Disease ID
Name
34
Neurofibromatosis
2
CDK6
💬
2. CDK6
×
Name
Full Name
CDK6
cyclin dependent kinase 6
[23]
Cell cycle
Cell cycle
,
p53 signaling pathway
,
PI3K-Akt signaling pathway
,
Cellular senescence
,
Cushing syndrome
,
Hepatitis C
,
Measles
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Pathways in cancer
,
Viral carcinogenesis
,
MicroRNAs in cancer
,
Pancreatic cancer
,
Glioma
,
Melanoma
,
Chronic myeloid leukemia
,
Small cell lung cancer
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
[23]
Cell cycle
,
p53 signaling pathway
,
PI3K-Akt signaling pathway
,
Cellular senescence
,
Cushing syn
...
Abemaciclib
Abemaciclib
💬
2. CDK6
×
Name
Other Names
Abemaciclib
Abemaciclib (JAN/USAN)
Verzenio (TN)
Abemaciclib
[1]
34
34
💬
2. CDK6
×
Disease ID
Name
34
Neurofibromatosis
3
MAPK14
💬
3. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
[62]
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[62]
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Losmapimod
Losmapimod
💬
3. MAPK14
×
Name
Other Names
Losmapimod
Losmapimod (USAN/INN)
Losmapimod
[2]
113
113
,
222
💬
3. MAPK14
×
Disease ID
Name
113
Muscular dystrophy
222
Primary nephrotic syndrome
4
MAPK14
💬
4. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
[62]
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[62]
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Neflamapimod
Neflamapimod
💬
4. MAPK14
×
Name
Other Names
Neflamapimod
Neflamapimod (USAN)
Neflamapimod
[1]
8
8
💬
4. MAPK14
×
Disease ID
Name
8
Huntington disease
5
HDAC1
💬
5. HDAC1
×
Name
Full Name
HDAC1
histone deacetylase 1
[15]
Cell cycle
Cell cycle
,
Longevity regulating pathway - multiple species
,
Notch signaling pathway
,
Neutrophil extracellular trap formation
,
Thyroid hormone signaling pathway
,
Huntington disease
,
Amphetamine addiction
,
Alcoholism
,
Human papillomavirus infection
,
Epstein-Barr virus infection
,
Pathways in cancer
,
Transcriptional misregulation in cancer
,
Viral carcinogenesis
,
MicroRNAs in cancer
,
Chronic myeloid leukemia
[15]
Cell cycle
,
Longevity regulating pathway - multiple species
,
Notch signaling pathway
,
Neutrophi
...
Vorinostat
Vorinostat
💬
5. HDAC1
×
Name
Other Names
Vorinostat
Vorinostat (JAN/USAN)
Zolinza (TN)
Vorinostat
[2]
75
75
,
96
💬
5. HDAC1
×
Disease ID
Name
75
Cushing disease
96
Crohn disease
6
HDAC2
💬
6. HDAC2
×
Name
Full Name
HDAC2
histone deacetylase 2
[15]
Cell cycle
Cell cycle
,
Longevity regulating pathway - multiple species
,
Notch signaling pathway
,
Neutrophil extracellular trap formation
,
Thyroid hormone signaling pathway
,
Huntington disease
,
Amphetamine addiction
,
Alcoholism
,
Human papillomavirus infection
,
Epstein-Barr virus infection
,
Pathways in cancer
,
Transcriptional misregulation in cancer
,
Viral carcinogenesis
,
MicroRNAs in cancer
,
Chronic myeloid leukemia
[15]
Cell cycle
,
Longevity regulating pathway - multiple species
,
Notch signaling pathway
,
Neutrophi
...
Vorinostat
Vorinostat
💬
6. HDAC2
×
Name
Other Names
Vorinostat
Vorinostat (JAN/USAN)
Zolinza (TN)
Vorinostat
[2]
75
75
,
96
💬
6. HDAC2
×
Disease ID
Name
75
Cushing disease
96
Crohn disease
7
IFNA1
💬
7. IFNA1
×
Name
Full Name
IFNA1
interferon alpha 1
[25]
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
Cytosolic DNA-sensing pathway
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
Alcoholic liver disease
,
Tuberculosis
,
Hepatitis C
,
Hepatitis B
,
Measles
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Autoimmune thyroid disease
,
Lipid and atherosclerosis
[25]
Cytokine-cytokine receptor interaction
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Toll-like rece
...
Rontalizumab
Rontalizumab
💬
7. IFNA1
×
Name
Other Names
Rontalizumab
Rontalizumab (USAN/INN)
Rontalizumab
[1]
49
49
💬
7. IFNA1
×
Disease ID
Name
49
Systemic lupus erythematosus
8
IFNA1
💬
8. IFNA1
×
Name
Full Name
IFNA1
interferon alpha 1
[25]
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
Cytosolic DNA-sensing pathway
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
Alcoholic liver disease
,
Tuberculosis
,
Hepatitis C
,
Hepatitis B
,
Measles
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Autoimmune thyroid disease
,
Lipid and atherosclerosis
[25]
Cytokine-cytokine receptor interaction
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Toll-like rece
...
Sifalimumab
Sifalimumab
💬
8. IFNA1
×
Name
Other Names
Sifalimumab
Sifalimumab (USAN/INN)
Sifalimumab
[1]
49
49
💬
8. IFNA1
×
Disease ID
Name
49
Systemic lupus erythematosus
9
IFNA2
💬
9. IFNA2
×
Name
Full Name
IFNA2
interferon alpha 2
[25]
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
Cytosolic DNA-sensing pathway
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
Alcoholic liver disease
,
Tuberculosis
,
Hepatitis C
,
Hepatitis B
,
Measles
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Autoimmune thyroid disease
,
Lipid and atherosclerosis
[25]
Cytokine-cytokine receptor interaction
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Toll-like rece
...
Rontalizumab
Rontalizumab
💬
9. IFNA2
×
Name
Other Names
Rontalizumab
Rontalizumab (USAN/INN)
Rontalizumab
[1]
49
49
💬
9. IFNA2
×
Disease ID
Name
49
Systemic lupus erythematosus
10
IFNA2
💬
10. IFNA2
×
Name
Full Name
IFNA2
interferon alpha 2
[25]
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
Cytosolic DNA-sensing pathway
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
Alcoholic liver disease
,
Tuberculosis
,
Hepatitis C
,
Hepatitis B
,
Measles
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Autoimmune thyroid disease
,
Lipid and atherosclerosis
[25]
Cytokine-cytokine receptor interaction
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Toll-like rece
...
Sifalimumab
Sifalimumab
💬
10. IFNA2
×
Name
Other Names
Sifalimumab
Sifalimumab (USAN/INN)
Sifalimumab
[1]
49
49
💬
10. IFNA2
×
Disease ID
Name
49
Systemic lupus erythematosus