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KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

ADRA2A 💬

[2] cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction

Dexmedetomidine 💬

Dexmedetomidine

[14] 2, 4, 6, 21, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
4	Primary lateral sclerosis
6	Parkinson disease
21	Mitochondrial disease
34	Neurofibromatosis
46	Malignant rheumatoid arthritis
70	Spinal stenosis
107	Juvenile idiopathic arthritis
113	Muscular dystrophy
171	Wilson disease
212	Tricuspid atresia
215	Tetralogy of Fallot
226	Interstitial cystitis with Hunners ulcer
280	Huge arteriovenous malformation with cervicofacial or limb lesion

ADRA2B 💬

[2] cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction

Dexmedetomidine 💬

Dexmedetomidine

[14] 2, 4, 6, 21, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
4	Primary lateral sclerosis
6	Parkinson disease
21	Mitochondrial disease
34	Neurofibromatosis
46	Malignant rheumatoid arthritis
70	Spinal stenosis
107	Juvenile idiopathic arthritis
113	Muscular dystrophy
171	Wilson disease
212	Tricuspid atresia
215	Tetralogy of Fallot
226	Interstitial cystitis with Hunners ulcer
280	Huge arteriovenous malformation with cervicofacial or limb lesion

ADRA2C 💬

[2] cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction

Dexmedetomidine 💬

Dexmedetomidine

[14] 2, 4, 6, 21, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
4	Primary lateral sclerosis
6	Parkinson disease
21	Mitochondrial disease
34	Neurofibromatosis
46	Malignant rheumatoid arthritis
70	Spinal stenosis
107	Juvenile idiopathic arthritis
113	Muscular dystrophy
171	Wilson disease
212	Tricuspid atresia
215	Tetralogy of Fallot
226	Interstitial cystitis with Hunners ulcer
280	Huge arteriovenous malformation with cervicofacial or limb lesion

ACE 💬

[6] Renin-angiotensin system, Renin secretion, Chagas disease, Coronavirus disease - COVID-19, Hyper ...

Captopril 💬

Captopril

[8] 6, 17, 46, 86, 96, 97, 107, 271 💬

Disease ID	Name
6	Parkinson disease
17	Multiple system atrophy
46	Malignant rheumatoid arthritis
86	Pulmonary arterial hypertension
96	Crohn disease
97	Ulcerative colitis
107	Juvenile idiopathic arthritis
271	Ankylosing spondylitis

HTR3C 💬

[2] Serotonergic synapse, Taste transduction

Ondansetron 💬

Ondansetron

[3] 6, 97, 107 💬

DHFR 💬

[5] One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...

Methotrexate 💬

Methotrexate

[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...

Disease ID	Name
11	Myasthenia gravis
13	Multiple sclerosis/Neuromyelitis optica
19	Lysosomal storage disease
34	Neurofibromatosis
35	Pemphigus
40	Takayasu arteritis
41	Giant cell arteritis
42	Polyarteritis nodosa
43	Microscopic polyangiitis
44	Wegener granulomatosis
45	Eosinophilic granulomatosis with Polyangiitis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
50	Dermatomyositis
51	Scleroderma
53	Sjogren syndrome
55	Relapsing polychondritis
56	Behcet disease
60	Aplastic anemia
62	Paroxysmal nocturnal hemoglobinuria
65	Primary immunodeficiency
84	Sarcoidosis
93	Primary biliary cholangitis
96	Crohn disease
97	Ulcerative colitis
107	Juvenile idiopathic arthritis
162	Pemphigoid
164	Oculocutaneous albinism
172	Hypophosphatasia
256	Muscle glycogenosis
270	Chronic recurrent multifocal osteomyelitis
271	Ankylosing spondylitis
283	Acquired pure red cell aplasia
284	Diamond-Blackfan anemia
285	Fanconi anemia
286	Hereditary sideroblastic anemia
326	Osteopetrosis
331	Idiopathic multicentric castleman disease

DHODH 💬

[3] Pyrimidine metabolism, Metabolic pathways, Biosynthesis of cofactors

Leflunomide 💬

Leflunomide

[12] 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300 💬

Disease ID	Name
11	Myasthenia gravis
40	Takayasu arteritis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
53	Sjogren syndrome
66	IgA nephropathy
107	Juvenile idiopathic arthritis
162	Pemphigoid
224	Purpura nephritis
270	Chronic recurrent multifocal osteomyelitis
271	Ankylosing spondylitis
300	IgG4-related disease

DHFR2 💬

[5] One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...

Methotrexate 💬

Methotrexate

[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...

Disease ID	Name
11	Myasthenia gravis
13	Multiple sclerosis/Neuromyelitis optica
19	Lysosomal storage disease
34	Neurofibromatosis
35	Pemphigus
40	Takayasu arteritis
41	Giant cell arteritis
42	Polyarteritis nodosa
43	Microscopic polyangiitis
44	Wegener granulomatosis
45	Eosinophilic granulomatosis with Polyangiitis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
50	Dermatomyositis
51	Scleroderma
53	Sjogren syndrome
55	Relapsing polychondritis
56	Behcet disease
60	Aplastic anemia
62	Paroxysmal nocturnal hemoglobinuria
65	Primary immunodeficiency
84	Sarcoidosis
93	Primary biliary cholangitis
96	Crohn disease
97	Ulcerative colitis
107	Juvenile idiopathic arthritis
162	Pemphigoid
164	Oculocutaneous albinism
172	Hypophosphatasia
256	Muscle glycogenosis
270	Chronic recurrent multifocal osteomyelitis
271	Ankylosing spondylitis
283	Acquired pure red cell aplasia
284	Diamond-Blackfan anemia
285	Fanconi anemia
286	Hereditary sideroblastic anemia
326	Osteopetrosis
331	Idiopathic multicentric castleman disease

HTR3D 💬

[2] Serotonergic synapse, Taste transduction

Ondansetron 💬

Ondansetron

[3] 6, 97, 107 💬

FDPS 💬

[4] Terpenoid backbone biosynthesis, Metabolic pathways, Influenza A, Human T-cell leukemia virus 1 ...

Risedronic acid 💬

Risedronic acid

[9] 46, 50, 66, 93, 95, 96, 107, 113, 274 💬

Disease ID	Name
46	Malignant rheumatoid arthritis
50	Dermatomyositis
66	IgA nephropathy
93	Primary biliary cholangitis
95	Autoimmune hepatitis
96	Crohn disease
107	Juvenile idiopathic arthritis
113	Muscular dystrophy
274	Osteogenesis Imperfecta

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