Target Gene/Pathway Pathway / Gene

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KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[11] Viral life cycle - HIV-1, Virion - Human immunodeficiency virus, Cytokine-cytokine receptor int ...

Cenicriviroc 💬

[1] 94 💬

2

[48] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...

[1] 94 💬

3

[1] Neuroactive ligand-receptor interaction

Budesonide 💬

[9] 66, 93, 94, 95, 96, 97, 98, 228, 299 💬

Disease ID	Name
66	IgA nephropathy
93	Primary biliary cholangitis
94	Primary sclerosing cholangitis
95	Autoimmune hepatitis
96	Crohn disease
97	Ulcerative colitis
98	Eosinophilic gastrointestinal disease
228	Bronchiolitis obliterans
299	Cystic fibrosis

4

[4] Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion

Simvastatin 💬

[21] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬

Disease ID	Name
6	Parkinson disease
13	Multiple sclerosis/Neuromyelitis optica
15	Inclusion body myositis
34	Neurofibromatosis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
51	Scleroderma
66	IgA nephropathy
79	Homozygous familial hypercholesterolemia
86	Pulmonary arterial hypertension
89	Lymphangioleiomyomatosis
94	Primary sclerosing cholangitis
158	Tuberous sclerosis
160	Congenital ichthyosis
162	Pemphigoid
195	Noonan syndrome
265	Lipodystrophy
288	Autoimmune acquired coagulation factor deficiency
298	Hereditary pancreatitis
299	Cystic fibrosis
310	Congenital anomalies syndrome

5

[4] Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism

Mizoribine 💬

[8] 46, 49, 51, 53, 66, 94, 222, 224 💬

Disease ID	Name
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
51	Scleroderma
53	Sjogren syndrome
66	IgA nephropathy
94	Primary sclerosing cholangitis
222	Primary nephrotic syndrome
224	Purpura nephritis

6

[4] Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism

Mizoribine 💬

[8] 46, 49, 51, 53, 66, 94, 222, 224 💬

Disease ID	Name
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
51	Scleroderma
53	Sjogren syndrome
66	IgA nephropathy
94	Primary sclerosing cholangitis
222	Primary nephrotic syndrome
224	Purpura nephritis

7

[14] PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Cell adhesion molecules, ...

Vedolizumab 💬

[3] 94, 96, 97 💬

8

[11] PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Cell adhesion molecules, ...

Vedolizumab 💬

[3] 94, 96, 97 💬

9

[7] Ubiquitin mediated proteolysis, Endocytosis, Influenza A, Herpes simplex virus 1 infection, Path ...

[6] 2, 62, 63, 75, 94, 231 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
62	Paroxysmal nocturnal hemoglobinuria
63	Idiopathic thrombocytopenic purpura
75	Cushing disease
94	Primary sclerosing cholangitis
231	Alpha-1-antitrypsin deficiency

10

[10] PPAR signaling pathway, cAMP signaling pathway, Adipocytokine signaling pathway, Glucagon signa ...

Fenofibrate 💬

[6] 8, 79, 93, 94, 97, 265 💬

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