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KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
Disease ID
1
MTOR
💬
1. MTOR
×
Name
Full Name
MTOR
mechanistic target of rapamycin kinase
[51]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1 signaling pathway
,
Phospholipase D signaling pathway
,
Autophagy - other
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
AMPK signaling pathway
,
Longevity regulating pathway
,
Longevity regulating pathway
- multiple species
,
Cellular senescence
,
Apelin signaling pathway
,
Neutrophil extracellular trap formation
,
JAK-STAT signaling pathway
,
Th17 cell differentiation
,
Thermogenesis
,
Insulin signaling pathway
,
Thyroid hormone signaling pathway
,
Adipocytokine signaling pathway
,
Type II diabetes mellitus
,
Insulin resistance
,
Growth hormone synthesis, secretion and action
,
Alzheimer disease
,
Amyotrophic lateral sclerosis
,
Huntington disease
,
Spinocerebellar ataxia
,
Pathways of neurodegeneration - multiple diseases
,
Shigellosis
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Human immunodeficiency virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Colorectal cancer
,
Pancreatic cancer
,
Glioma
,
Prostate cancer
,
Acute myeloid leukemia
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
[51]
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1
...
Sirolimus
Sirolimus
💬
1. MTOR
×
Name
Other Names
Sirolimus
Sirolimus (JAN/USAN/INN)
Rapamune (TN)
Rapamycin (TN)
FYARRO
HYFTOR
Sirolimus
[40]
2
2
,
13
,
15
,
17
,
19
,
34
,
35
,
36
,
46
,
49
,
51
,
53
,
60
,
61
,
62
,
63
,
65
,
66
,
67
,
84
,
85
,
86
,
89
,
96
,
98
,
137
,
157
,
158
,
192
,
193
,
222
,
256
,
277
,
278
,
279
,
280
,
281
,
283
,
300
,
331
💬
[40]
2
,
13
,
15
,
17
,
19
,
34
,
35
,
36
,
46
,
49
,
51
,
53
,
60
,
61
,
62
,
63
,
65
,
66
,
67
,
84
,
85
,
86
,
89
,
96
, ...
1. MTOR
×
Disease ID
Name
2
Amyotrophic lateral sclerosis
13
Multiple sclerosis/Neuromyelitis optica
15
Inclusion body myositis
17
Multiple system atrophy
19
Lysosomal storage disease
34
Neurofibromatosis
35
Pemphigus
36
Epidermolysis bullosa
46
Malignant rheumatoid arthritis
49
Systemic lupus erythematosus
51
Scleroderma
53
Sjogren syndrome
60
Aplastic anemia
61
Autoimmune hemolytic anemia
62
Paroxysmal nocturnal hemoglobinuria
63
Idiopathic thrombocytopenic purpura
65
Primary immunodeficiency
66
IgA nephropathy
67
Polycystic kidney disease
84
Sarcoidosis
85
Idiopathic interstitial pneumonia
86
Pulmonary arterial hypertension
89
Lymphangioleiomyomatosis
96
Crohn disease
98
Eosinophilic gastrointestinal disease
137
Focal cortical dysplasia
157
Sturge-Weber syndrome
158
Tuberous sclerosis
192
Cockayne syndrome
193
Prader-Willi syndrome
222
Primary nephrotic syndrome
256
Muscle glycogenosis
277
Lymphangiomatosis
278
Huge lymphatic malformation with cervicofacial lesion
279
Huge venous malformation with cervical, oral and pharyngeal diffuse lesion
280
Huge arteriovenous malformation with cervicofacial or limb lesion
281
Klippel-Trenaunay-Weber syndrome
283
Acquired pure red cell aplasia
300
IgG4-related disease
331
Idiopathic multicentric castleman disease
2
MTOR
💬
2. MTOR
×
Name
Full Name
MTOR
mechanistic target of rapamycin kinase
[51]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1 signaling pathway
,
Phospholipase D signaling pathway
,
Autophagy - other
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
AMPK signaling pathway
,
Longevity regulating pathway
,
Longevity regulating pathway
- multiple species
,
Cellular senescence
,
Apelin signaling pathway
,
Neutrophil extracellular trap formation
,
JAK-STAT signaling pathway
,
Th17 cell differentiation
,
Thermogenesis
,
Insulin signaling pathway
,
Thyroid hormone signaling pathway
,
Adipocytokine signaling pathway
,
Type II diabetes mellitus
,
Insulin resistance
,
Growth hormone synthesis, secretion and action
,
Alzheimer disease
,
Amyotrophic lateral sclerosis
,
Huntington disease
,
Spinocerebellar ataxia
,
Pathways of neurodegeneration - multiple diseases
,
Shigellosis
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Human immunodeficiency virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Colorectal cancer
,
Pancreatic cancer
,
Glioma
,
Prostate cancer
,
Acute myeloid leukemia
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
[51]
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1
...
Everolimus
Everolimus
💬
2. MTOR
×
Name
Other Names
Everolimus
Everolimus (JAN/USAN/INN)
Afinitor (TN)
Votubia (TN)
Zortress (TN)
Everolimus
[9]
34
34
,
67
,
89
,
96
,
137
,
157
,
158
,
228
,
277
💬
2. MTOR
×
Disease ID
Name
34
Neurofibromatosis
67
Polycystic kidney disease
89
Lymphangioleiomyomatosis
96
Crohn disease
137
Focal cortical dysplasia
157
Sturge-Weber syndrome
158
Tuberous sclerosis
228
Bronchiolitis obliterans
277
Lymphangiomatosis
3
MTOR
💬
3. MTOR
×
Name
Full Name
MTOR
mechanistic target of rapamycin kinase
[51]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1 signaling pathway
,
Phospholipase D signaling pathway
,
Autophagy - other
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
AMPK signaling pathway
,
Longevity regulating pathway
,
Longevity regulating pathway
- multiple species
,
Cellular senescence
,
Apelin signaling pathway
,
Neutrophil extracellular trap formation
,
JAK-STAT signaling pathway
,
Th17 cell differentiation
,
Thermogenesis
,
Insulin signaling pathway
,
Thyroid hormone signaling pathway
,
Adipocytokine signaling pathway
,
Type II diabetes mellitus
,
Insulin resistance
,
Growth hormone synthesis, secretion and action
,
Alzheimer disease
,
Amyotrophic lateral sclerosis
,
Huntington disease
,
Spinocerebellar ataxia
,
Pathways of neurodegeneration - multiple diseases
,
Shigellosis
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Human immunodeficiency virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Colorectal cancer
,
Pancreatic cancer
,
Glioma
,
Prostate cancer
,
Acute myeloid leukemia
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
[51]
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1
...
Temsirolimus
Temsirolimus
💬
3. MTOR
×
Name
Other Names
Temsirolimus
Temsirolimus (JAN/USAN/INN)
Torisel (TN)
Temsirolimus
[1]
13
13
💬
3. MTOR
×
Disease ID
Name
13
Multiple sclerosis/Neuromyelitis optica
4
HDAC1
💬
4. HDAC1
×
Name
Full Name
HDAC1
histone deacetylase 1
[15]
Cell cycle
Cell cycle
,
Longevity regulating pathway
- multiple species
,
Notch signaling pathway
,
Neutrophil extracellular trap formation
,
Thyroid hormone signaling pathway
,
Huntington disease
,
Amphetamine addiction
,
Alcoholism
,
Human papillomavirus infection
,
Epstein-Barr virus infection
,
Pathways in cancer
,
Transcriptional misregulation in cancer
,
Viral carcinogenesis
,
MicroRNAs in cancer
,
Chronic myeloid leukemia
[15]
Cell cycle
,
Longevity regulating pathway
- multiple species
,
Notch signaling pathway
,
Neutrophil
...
Vorinostat
Vorinostat
💬
4. HDAC1
×
Name
Other Names
Vorinostat
Vorinostat (JAN/USAN)
Zolinza (TN)
Vorinostat
[2]
75
75
,
96
💬
4. HDAC1
×
Disease ID
Name
75
Cushing disease
96
Crohn disease
5
HDAC2
💬
5. HDAC2
×
Name
Full Name
HDAC2
histone deacetylase 2
[15]
Cell cycle
Cell cycle
,
Longevity regulating pathway
- multiple species
,
Notch signaling pathway
,
Neutrophil extracellular trap formation
,
Thyroid hormone signaling pathway
,
Huntington disease
,
Amphetamine addiction
,
Alcoholism
,
Human papillomavirus infection
,
Epstein-Barr virus infection
,
Pathways in cancer
,
Transcriptional misregulation in cancer
,
Viral carcinogenesis
,
MicroRNAs in cancer
,
Chronic myeloid leukemia
[15]
Cell cycle
,
Longevity regulating pathway
- multiple species
,
Notch signaling pathway
,
Neutrophil
...
Vorinostat
Vorinostat
💬
5. HDAC2
×
Name
Other Names
Vorinostat
Vorinostat (JAN/USAN)
Zolinza (TN)
Vorinostat
[2]
75
75
,
96
💬
5. HDAC2
×
Disease ID
Name
75
Cushing disease
96
Crohn disease
6
IGF1R
💬
6. IGF1R
×
Name
Full Name
IGF1R
insulin like growth factor 1 receptor
[29]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Oocyte meiosis
,
Autophagy - animal
,
Endocytosis
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
AMPK signaling pathway
,
Longevity regulating pathway
,
Longevity regulating pathway
- multiple species
,
Focal adhesion
,
Adherens junction
,
Signaling pathways regulating pluripotency of stem cells
,
Long-term depression
,
Ovarian steroidogenesis
,
Progesterone-mediated oocyte maturation
,
Pathways in cancer
,
Transcriptional misregulation in cancer
,
Proteoglycans in cancer
,
Glioma
,
Prostate cancer
,
Melanoma
,
Breast cancer
,
Hepatocellular carcinoma
[29]
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
Ras si
...
Mecasermin
Mecasermin
💬
6. IGF1R
×
Name
Other Names
Mecasermin
Mecasermin (USAN/INN)
Mecasermin (genetical recombination) (JAN)
Increlex (TN)
Myotrophin (TN)
Mecasermin
[6]
65
65
,
78
,
96
,
168
,
265
,
299
💬
6. IGF1R
×
Disease ID
Name
65
Primary immunodeficiency
78
Hypopituitarism
96
Crohn disease
168
Ehlers-Danlos syndrome
265
Lipodystrophy
299
Cystic fibrosis
7
IGF1R
💬
7. IGF1R
×
Name
Full Name
IGF1R
insulin like growth factor 1 receptor
[29]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Oocyte meiosis
,
Autophagy - animal
,
Endocytosis
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
AMPK signaling pathway
,
Longevity regulating pathway
,
Longevity regulating pathway
- multiple species
,
Focal adhesion
,
Adherens junction
,
Signaling pathways regulating pluripotency of stem cells
,
Long-term depression
,
Ovarian steroidogenesis
,
Progesterone-mediated oocyte maturation
,
Pathways in cancer
,
Transcriptional misregulation in cancer
,
Proteoglycans in cancer
,
Glioma
,
Prostate cancer
,
Melanoma
,
Breast cancer
,
Hepatocellular carcinoma
[29]
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
Ras si
...
Teprotumumab
Teprotumumab
💬
7. IGF1R
×
Name
Other Names
Teprotumumab
Teprotumumab (USAN/INN)
Teprotumumab-trbw
Tepezza (TN)
Teprotumumab
[1]
51
51
💬
7. IGF1R
×
Disease ID
Name
51
Scleroderma
8
IGF1R
💬
8. IGF1R
×
Name
Full Name
IGF1R
insulin like growth factor 1 receptor
[29]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Oocyte meiosis
,
Autophagy - animal
,
Endocytosis
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
AMPK signaling pathway
,
Longevity regulating pathway
,
Longevity regulating pathway
- multiple species
,
Focal adhesion
,
Adherens junction
,
Signaling pathways regulating pluripotency of stem cells
,
Long-term depression
,
Ovarian steroidogenesis
,
Progesterone-mediated oocyte maturation
,
Pathways in cancer
,
Transcriptional misregulation in cancer
,
Proteoglycans in cancer
,
Glioma
,
Prostate cancer
,
Melanoma
,
Breast cancer
,
Hepatocellular carcinoma
[29]
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
Ras si
...
Linsitinib
Linsitinib
💬
8. IGF1R
×
Name
Other Names
Linsitinib
Linsitinib (USAN/INN)
Linsitinib
[1]
232
232
💬
8. IGF1R
×
Disease ID
Name
232
Carney complex
9
INSR
💬
9. INSR
×
Name
Full Name
INSR
insulin receptor
[22]
MAPK signaling pathway
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
cGMP-PKG signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Phospholipase D signaling pathway
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
AMPK signaling pathway
,
Longevity regulating pathway
,
Longevity regulating pathway
- multiple species
,
Adherens junction
,
Insulin signaling pathway
,
Ovarian steroidogenesis
,
Regulation of lipolysis in adipocytes
,
Type II diabetes mellitus
,
Insulin resistance
,
Non-alcoholic fatty liver disease
,
Aldosterone-regulated sodium reabsorption
,
Alzheimer disease
,
Diabetic cardiomyopathy
[22]
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
cGMP-PKG signaling pathw
...
Insulin human
Insulin human
💬
9. INSR
×
Name
Other Names
Insulin human
Insulin human (USP/INN)
Insulin human (genetical recombination) (JP18)
Insulin human (biosynthesis) (JAN)
Insulin human (synthesis) (JAN)
Humulin (TN)
MYXREDLIN
Insulin human
[2]
96
96
,
156
💬
9. INSR
×
Disease ID
Name
96
Crohn disease
156
Rett syndrome
10
INSR
💬
10. INSR
×
Name
Full Name
INSR
insulin receptor
[22]
MAPK signaling pathway
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
cGMP-PKG signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Phospholipase D signaling pathway
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
AMPK signaling pathway
,
Longevity regulating pathway
,
Longevity regulating pathway
- multiple species
,
Adherens junction
,
Insulin signaling pathway
,
Ovarian steroidogenesis
,
Regulation of lipolysis in adipocytes
,
Type II diabetes mellitus
,
Insulin resistance
,
Non-alcoholic fatty liver disease
,
Aldosterone-regulated sodium reabsorption
,
Alzheimer disease
,
Diabetic cardiomyopathy
[22]
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
cGMP-PKG signaling pathw
...
Insulin glargine
Insulin glargine
💬
10. INSR
×
Name
Other Names
Insulin glargine
Insulin glargine (USAN/INN)
Insulin glargine (genetical recombination) (JP18)
Insulin glargine (genetical recombination) [Insulin glargin biosimilar 1] (JAN)
Insulin glargine (genetical recombination) [Insulin glargin biosimilar 2] (JAN)
Lantus (TN)
BASAGLAR
INSULIN GLARGINE SOLOSTAR
LANTUS SOLOSTAR
REZVOGLAR
SEMGLEE
TOUJEO
TOUJEO MAX
Insulin glargine
[1]
299
299
💬
10. INSR
×
Disease ID
Name
299
Cystic fibrosis