DDrare
Disease
Drug
Target Gene/Pathway
Contact
JA
Target Gene/Pathway
Pathway
/
Gene
Search
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Other
Search results
10
50
100
ALL
entries per page:
Showing 1 to 10 of 88 entries
Filter by
Reset
|
No.
KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
Disease ID
1
CDK4
💬
1. CDK4
×
Name
Full Name
CDK4
cyclin dependent kinase 4
[28]
Endocrine resistance
Endocrine resistance
,
Cell cycle
,
p53 signaling pathway
,
PI3K-Akt signaling pathway
,
Cellular senescence
,
Tight junction
,
T cell receptor signaling pathway
,
AGE-RAGE signaling pathway in diabetic complications
,
Cushing syndrome
,
Hepatitis C
,
Measles
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Pathways in cancer
,
Viral carcinogenesis
,
Pancreatic cancer
,
Glioma
,
Melanoma
,
Bladder cancer
,
Chronic myeloid leukemia
,
Small cell lung cancer
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
[28]
Endocrine resistance
,
Cell cycle
,
p53 signaling pathway
,
PI3K-Akt signaling pathway
,
Cellular s
...
Abemaciclib
Abemaciclib
💬
1. CDK4
×
Name
Other Names
Abemaciclib
Abemaciclib (JAN/USAN)
Verzenio (TN)
Abemaciclib
[1]
34
34
💬
1. CDK4
×
Disease ID
Name
34
Neurofibromatosis
2
MAPK14
💬
2. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
[62]
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[62]
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Losmapimod
Losmapimod
💬
2. MAPK14
×
Name
Other Names
Losmapimod
Losmapimod (USAN/INN)
Losmapimod
[2]
113
113
,
222
💬
2. MAPK14
×
Disease ID
Name
113
Muscular dystrophy
222
Primary nephrotic syndrome
3
MAPK14
💬
3. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
[62]
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[62]
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Neflamapimod
Neflamapimod
💬
3. MAPK14
×
Name
Other Names
Neflamapimod
Neflamapimod (USAN)
Neflamapimod
[1]
8
8
💬
3. MAPK14
×
Disease ID
Name
8
Huntington disease
4
CSF2
💬
4. CSF2
×
Name
Full Name
CSF2
colony stimulating factor 2
[16]
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
JAK-STAT signaling pathway
,
Hematopoietic cell lineage
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Shigellosis
,
Amoebiasis
,
Human T-cell leukemia virus 1 infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Coronavirus disease - COVID-19
,
Transcriptional misregulation in cancer
,
Acute myeloid leukemia
,
Rheumatoid arthritis
[16]
Cytokine-cytokine receptor interaction
,
JAK-STAT signaling pathway
,
Hematopoietic cell lineage
, ...
Otilimab
Otilimab
💬
4. CSF2
×
Name
Other Names
Otilimab
Otilimab (USAN)
Otilimab (genetical recombination) (JAN)
Otilimab
[1]
46
46
💬
4. CSF2
×
Disease ID
Name
46
Malignant rheumatoid arthritis
5
CTLA4
💬
5. CTLA4
×
Name
Full Name
CTLA4
cytotoxic T-lymphocyte associated protein 4
[4]
Cell adhesion molecules
Cell adhesion molecules
,
T cell receptor signaling pathway
,
Autoimmune thyroid disease
,
Rheumatoid arthritis
[4]
Cell adhesion molecules
,
T cell receptor signaling pathway
,
Autoimmune thyroid disease
,
Rheumato
...
Ipilimumab
Ipilimumab
💬
5. CTLA4
×
Name
Other Names
Ipilimumab
Ipilimumab (USAN/INN)
Ipilimumab (genetical recombination) (JAN)
Yervoy (TN)
Ipilimumab
[1]
159
159
💬
5. CTLA4
×
Disease ID
Name
159
Xeroderma pigmentosum
6
CTLA4
💬
6. CTLA4
×
Name
Full Name
CTLA4
cytotoxic T-lymphocyte associated protein 4
[4]
Cell adhesion molecules
Cell adhesion molecules
,
T cell receptor signaling pathway
,
Autoimmune thyroid disease
,
Rheumatoid arthritis
[4]
Cell adhesion molecules
,
T cell receptor signaling pathway
,
Autoimmune thyroid disease
,
Rheumato
...
Tremelimumab
Tremelimumab
💬
6. CTLA4
×
Name
Other Names
Tremelimumab
Tremelimumab (USAN/INN)
Tremelimumab (genetical recombination) (JAN)
Tremelimumab-actl
CP 675206
Imjudo (TN)
Tremelimumab
[1]
96
96
💬
6. CTLA4
×
Disease ID
Name
96
Crohn disease
7
FYN
💬
7. FYN
×
Name
Full Name
FYN
FYN proto-oncogene, Src family tyrosine kinase
[14]
Sphingolipid signaling pathway
Sphingolipid signaling pathway
,
Phospholipase D signaling pathway
,
Axon guidance
,
Osteoclast differentiation
,
Focal adhesion
,
Adherens junction
,
Platelet activation
,
Natural killer cell mediated cytotoxicity
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Cholinergic synapse
,
Prion disease
,
Pathogenic Escherichia coli infection
,
Viral myocarditis
[14]
Sphingolipid signaling pathway
,
Phospholipase D signaling pathway
,
Axon guidance
,
Osteoclast di
...
Dasatinib
Dasatinib
💬
7. FYN
×
Name
Other Names
Dasatinib
Dasatinib (JAN/INN)
Dasatinib
[2]
51
51
,
85
💬
7. FYN
×
Disease ID
Name
51
Scleroderma
85
Idiopathic interstitial pneumonia
8
FYN
💬
8. FYN
×
Name
Full Name
FYN
FYN proto-oncogene, Src family tyrosine kinase
[14]
Sphingolipid signaling pathway
Sphingolipid signaling pathway
,
Phospholipase D signaling pathway
,
Axon guidance
,
Osteoclast differentiation
,
Focal adhesion
,
Adherens junction
,
Platelet activation
,
Natural killer cell mediated cytotoxicity
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Cholinergic synapse
,
Prion disease
,
Pathogenic Escherichia coli infection
,
Viral myocarditis
[14]
Sphingolipid signaling pathway
,
Phospholipase D signaling pathway
,
Axon guidance
,
Osteoclast di
...
Dasatinib
Dasatinib
💬
8. FYN
×
Name
Other Names
Dasatinib
Dasatinib (USAN)
Dasatinib hydrate (JAN)
Sprycel (TN)
Dasatinib
[2]
51
51
,
85
💬
8. FYN
×
Disease ID
Name
51
Scleroderma
85
Idiopathic interstitial pneumonia
9
IFNG
💬
9. IFNG
×
Name
Full Name
IFNG
interferon gamma
[32]
Proteasome
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Antigen processing and presentation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Type I diabetes mellitus
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis C
,
Influenza A
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
,
Allograft rejection
,
Graft-versus-host disease
,
Fluid shear stress and atherosclerosis
[32]
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-b
...
Fontolizumab
Fontolizumab
💬
9. IFNG
×
Name
Other Names
Fontolizumab
Fontolizumab (USAN/INN)
Fontolizumab
[1]
46
46
💬
9. IFNG
×
Disease ID
Name
46
Malignant rheumatoid arthritis
10
IFNG
💬
10. IFNG
×
Name
Full Name
IFNG
interferon gamma
[32]
Proteasome
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Antigen processing and presentation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Type I diabetes mellitus
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis C
,
Influenza A
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
,
Allograft rejection
,
Graft-versus-host disease
,
Fluid shear stress and atherosclerosis
[32]
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-b
...
Emapalumab
Emapalumab
💬
10. IFNG
×
Name
Other Names
Emapalumab
Emapalumab (USAN/INN)
Emapalumab (genetical recombination) (JAN)
Emapalumab-lzsg
Gamifant (TN)
Emapalumab
[3]
49
49
,
65
,
107
💬
10. IFNG
×
Disease ID
Name
49
Systemic lupus erythematosus
65
Primary immunodeficiency
107
Juvenile idiopathic arthritis