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KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
Disease ID
1
IL17F
💬
1. IL17F
×
Name
Full Name
IL17F
interleukin 17F
[4]
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
IL-17 signaling pathway
,
Th17 cell differentiation
,
Inflammatory bowel disease
[4]
Cytokine-cytokine receptor interaction
,
IL-17 signaling pathway
,
Th17 cell differentiation
,
Infl
...
Bimekizumab
Bimekizumab
💬
1. IL17F
×
Name
Other Names
Bimekizumab
Bimekizumab (USAN/INN)
Bimekizumab (genetical recombination) (JAN)
Bimzelx (TN)
Bimekizumab
[3]
46
46
,
97
,
271
💬
1. IL17F
×
Disease ID
Name
46
Malignant rheumatoid arthritis
97
Ulcerative colitis
271
Ankylosing spondylitis
2
MAPK14
💬
2. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
[62]
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[62]
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Losmapimod
Losmapimod
💬
2. MAPK14
×
Name
Other Names
Losmapimod
Losmapimod (USAN/INN)
Losmapimod
[2]
113
113
,
222
💬
2. MAPK14
×
Disease ID
Name
113
Muscular dystrophy
222
Primary nephrotic syndrome
3
MAPK14
💬
3. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
[62]
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[62]
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Neflamapimod
Neflamapimod
💬
3. MAPK14
×
Name
Other Names
Neflamapimod
Neflamapimod (USAN)
Neflamapimod
[1]
8
8
💬
3. MAPK14
×
Disease ID
Name
8
Huntington disease
4
MTOR
💬
4. MTOR
×
Name
Full Name
MTOR
mechanistic target of rapamycin kinase
[51]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1 signaling pathway
,
Phospholipase D signaling pathway
,
Autophagy - other
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
AMPK signaling pathway
,
Longevity regulating pathway
,
Longevity regulating pathway - multiple species
,
Cellular senescence
,
Apelin signaling pathway
,
Neutrophil extracellular trap formation
,
JAK-STAT signaling pathway
,
Th17 cell differentiation
,
Thermogenesis
,
Insulin signaling pathway
,
Thyroid hormone signaling pathway
,
Adipocytokine signaling pathway
,
Type II diabetes mellitus
,
Insulin resistance
,
Growth hormone synthesis, secretion and action
,
Alzheimer disease
,
Amyotrophic lateral sclerosis
,
Huntington disease
,
Spinocerebellar ataxia
,
Pathways of neurodegeneration - multiple diseases
,
Shigellosis
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Human immunodeficiency virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Colorectal cancer
,
Pancreatic cancer
,
Glioma
,
Prostate cancer
,
Acute myeloid leukemia
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
[51]
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1
...
Sirolimus
Sirolimus
💬
4. MTOR
×
Name
Other Names
Sirolimus
Sirolimus (JAN/USAN/INN)
Rapamune (TN)
Rapamycin (TN)
FYARRO
HYFTOR
Sirolimus
[40]
2
2
,
13
,
15
,
17
,
19
,
34
,
35
,
36
,
46
,
49
,
51
,
53
,
60
,
61
,
62
,
63
,
65
,
66
,
67
,
84
,
85
,
86
,
89
,
96
,
98
,
137
,
157
,
158
,
192
,
193
,
222
,
256
,
277
,
278
,
279
,
280
,
281
,
283
,
300
,
331
💬
[40]
2
,
13
,
15
,
17
,
19
,
34
,
35
,
36
,
46
,
49
,
51
,
53
,
60
,
61
,
62
,
63
,
65
,
66
,
67
,
84
,
85
,
86
,
89
,
96
, ...
4. MTOR
×
Disease ID
Name
2
Amyotrophic lateral sclerosis
13
Multiple sclerosis/Neuromyelitis optica
15
Inclusion body myositis
17
Multiple system atrophy
19
Lysosomal storage disease
34
Neurofibromatosis
35
Pemphigus
36
Epidermolysis bullosa
46
Malignant rheumatoid arthritis
49
Systemic lupus erythematosus
51
Scleroderma
53
Sjogren syndrome
60
Aplastic anemia
61
Autoimmune hemolytic anemia
62
Paroxysmal nocturnal hemoglobinuria
63
Idiopathic thrombocytopenic purpura
65
Primary immunodeficiency
66
IgA nephropathy
67
Polycystic kidney disease
84
Sarcoidosis
85
Idiopathic interstitial pneumonia
86
Pulmonary arterial hypertension
89
Lymphangioleiomyomatosis
96
Crohn disease
98
Eosinophilic gastrointestinal disease
137
Focal cortical dysplasia
157
Sturge-Weber syndrome
158
Tuberous sclerosis
192
Cockayne syndrome
193
Prader-Willi syndrome
222
Primary nephrotic syndrome
256
Muscle glycogenosis
277
Lymphangiomatosis
278
Huge lymphatic malformation with cervicofacial lesion
279
Huge venous malformation with cervical, oral and pharyngeal diffuse lesion
280
Huge arteriovenous malformation with cervicofacial or limb lesion
281
Klippel-Trenaunay-Weber syndrome
283
Acquired pure red cell aplasia
300
IgG4-related disease
331
Idiopathic multicentric castleman disease
5
MTOR
💬
5. MTOR
×
Name
Full Name
MTOR
mechanistic target of rapamycin kinase
[51]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1 signaling pathway
,
Phospholipase D signaling pathway
,
Autophagy - other
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
AMPK signaling pathway
,
Longevity regulating pathway
,
Longevity regulating pathway - multiple species
,
Cellular senescence
,
Apelin signaling pathway
,
Neutrophil extracellular trap formation
,
JAK-STAT signaling pathway
,
Th17 cell differentiation
,
Thermogenesis
,
Insulin signaling pathway
,
Thyroid hormone signaling pathway
,
Adipocytokine signaling pathway
,
Type II diabetes mellitus
,
Insulin resistance
,
Growth hormone synthesis, secretion and action
,
Alzheimer disease
,
Amyotrophic lateral sclerosis
,
Huntington disease
,
Spinocerebellar ataxia
,
Pathways of neurodegeneration - multiple diseases
,
Shigellosis
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Human immunodeficiency virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Colorectal cancer
,
Pancreatic cancer
,
Glioma
,
Prostate cancer
,
Acute myeloid leukemia
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
[51]
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1
...
Everolimus
Everolimus
💬
5. MTOR
×
Name
Other Names
Everolimus
Everolimus (JAN/USAN/INN)
Afinitor (TN)
Votubia (TN)
Zortress (TN)
Everolimus
[9]
34
34
,
67
,
89
,
96
,
137
,
157
,
158
,
228
,
277
💬
5. MTOR
×
Disease ID
Name
34
Neurofibromatosis
67
Polycystic kidney disease
89
Lymphangioleiomyomatosis
96
Crohn disease
137
Focal cortical dysplasia
157
Sturge-Weber syndrome
158
Tuberous sclerosis
228
Bronchiolitis obliterans
277
Lymphangiomatosis
6
MTOR
💬
6. MTOR
×
Name
Full Name
MTOR
mechanistic target of rapamycin kinase
[51]
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1 signaling pathway
,
Phospholipase D signaling pathway
,
Autophagy - other
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
AMPK signaling pathway
,
Longevity regulating pathway
,
Longevity regulating pathway - multiple species
,
Cellular senescence
,
Apelin signaling pathway
,
Neutrophil extracellular trap formation
,
JAK-STAT signaling pathway
,
Th17 cell differentiation
,
Thermogenesis
,
Insulin signaling pathway
,
Thyroid hormone signaling pathway
,
Adipocytokine signaling pathway
,
Type II diabetes mellitus
,
Insulin resistance
,
Growth hormone synthesis, secretion and action
,
Alzheimer disease
,
Amyotrophic lateral sclerosis
,
Huntington disease
,
Spinocerebellar ataxia
,
Pathways of neurodegeneration - multiple diseases
,
Shigellosis
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Human immunodeficiency virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Colorectal cancer
,
Pancreatic cancer
,
Glioma
,
Prostate cancer
,
Acute myeloid leukemia
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
[51]
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1
...
Temsirolimus
Temsirolimus
💬
6. MTOR
×
Name
Other Names
Temsirolimus
Temsirolimus (JAN/USAN/INN)
Torisel (TN)
Temsirolimus
[1]
13
13
💬
6. MTOR
×
Disease ID
Name
13
Multiple sclerosis/Neuromyelitis optica
7
IFNG
💬
7. IFNG
×
Name
Full Name
IFNG
interferon gamma
[32]
Proteasome
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Antigen processing and presentation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Type I diabetes mellitus
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis C
,
Influenza A
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
,
Allograft rejection
,
Graft-versus-host disease
,
Fluid shear stress and atherosclerosis
[32]
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-b
...
Fontolizumab
Fontolizumab
💬
7. IFNG
×
Name
Other Names
Fontolizumab
Fontolizumab (USAN/INN)
Fontolizumab
[1]
46
46
💬
7. IFNG
×
Disease ID
Name
46
Malignant rheumatoid arthritis
8
IFNG
💬
8. IFNG
×
Name
Full Name
IFNG
interferon gamma
[32]
Proteasome
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Antigen processing and presentation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Type I diabetes mellitus
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis C
,
Influenza A
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
,
Allograft rejection
,
Graft-versus-host disease
,
Fluid shear stress and atherosclerosis
[32]
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-b
...
Emapalumab
Emapalumab
💬
8. IFNG
×
Name
Other Names
Emapalumab
Emapalumab (USAN/INN)
Emapalumab (genetical recombination) (JAN)
Emapalumab-lzsg
Gamifant (TN)
Emapalumab
[3]
49
49
,
65
,
107
💬
8. IFNG
×
Disease ID
Name
49
Systemic lupus erythematosus
65
Primary immunodeficiency
107
Juvenile idiopathic arthritis
9
IFNGR1
💬
9. IFNGR1
×
Name
Full Name
IFNGR1
interferon gamma receptor 1
[18]
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Influenza A
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
[18]
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
Osteoclast differ
...
Interferon gamma-1b
Interferon gamma-1b
💬
9. IFNGR1
×
Name
Other Names
Interferon gamma-1b
Interferon gamma-1b (USAN/INN)
Actimmune (TN)
Interferon gamma-1b
[7]
18
18
,
65
,
85
,
228
,
299
,
301
,
326
💬
9. IFNGR1
×
Disease ID
Name
18
Spinocerebellar degeneration
65
Primary immunodeficiency
85
Idiopathic interstitial pneumonia
228
Bronchiolitis obliterans
299
Cystic fibrosis
301
Macular dystrophy
326
Osteopetrosis
10
IFNGR2
💬
10. IFNGR2
×
Name
Full Name
IFNGR2
interferon gamma receptor 2
[17]
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Influenza A
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
[17]
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
Osteoclast differ
...
Interferon gamma-1b
Interferon gamma-1b
💬
10. IFNGR2
×
Name
Other Names
Interferon gamma-1b
Interferon gamma-1b (USAN/INN)
Actimmune (TN)
Interferon gamma-1b
[7]
18
18
,
65
,
85
,
228
,
299
,
301
,
326
💬
10. IFNGR2
×
Disease ID
Name
18
Spinocerebellar degeneration
65
Primary immunodeficiency
85
Idiopathic interstitial pneumonia
228
Bronchiolitis obliterans
299
Cystic fibrosis
301
Macular dystrophy
326
Osteopetrosis