Target Gene/Pathway Pathway / Gene

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KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[62] Endocrine resistance, MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, S ...

Losmapimod 💬

[2] 113, 222 💬

2

[62] Endocrine resistance, MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, S ...

Neflamapimod 💬

[1] 8 💬

3

[7] Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, Biosynthesis of cofacto ...

[11] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91 💬

Disease ID	Name
6	Parkinson disease
8	Huntington disease
13	Multiple sclerosis/Neuromyelitis optica
19	Lysosomal storage disease
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
66	IgA nephropathy
85	Idiopathic interstitial pneumonia
86	Pulmonary arterial hypertension
88	Chronic thromboembolic pulmonary hypertension
91	Budd-Chiari syndrome

4

[10] Porphyrin metabolism, Metabolic pathways, HIF-1 signaling pathway, Ferroptosis, Mineral absorpt ...

Stannsoporfin 💬

[1] 254 💬

5

[32] Proteasome, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Necroptosis, TGF-b ...

Fontolizumab 💬

[1] 46 💬

6

[32] Proteasome, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Necroptosis, TGF-b ...

Emapalumab 💬

[3] 49, 65, 107 💬

7

[21] MAPK signaling pathway, Cytokine-cytokine receptor interaction, Necroptosis, Cellular senescenc ...

Pirfenidone 💬

[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica
34	Neurofibromatosis
46	Malignant rheumatoid arthritis
50	Dermatomyositis
51	Scleroderma
58	Hypertrophic cardiomyopathy
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
164	Oculocutaneous albinism
222	Primary nephrotic syndrome
228	Bronchiolitis obliterans

8

[21] MAPK signaling pathway, Cytokine-cytokine receptor interaction, Necroptosis, Cellular senescenc ...

Rilonacept 💬

[4] 51, 106, 107, 266 💬

9

[21] MAPK signaling pathway, Cytokine-cytokine receptor interaction, Necroptosis, Cellular senescenc ...

Bermekimab 💬

[1] 51 💬

10

[44] Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa ...

Pirfenidone 💬

[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica
34	Neurofibromatosis
46	Malignant rheumatoid arthritis
50	Dermatomyositis
51	Scleroderma
58	Hypertrophic cardiomyopathy
84	Sarcoidosis
85	Idiopathic interstitial pneumonia
164	Oculocutaneous albinism
222	Primary nephrotic syndrome
228	Bronchiolitis obliterans

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